Which of the following drugs may inhibit the hepatic microsomal P450 responsible for warfarin metabolism (a) Cimetidine (b) Ethanol (c) Phenobarbital (d) Procainamide (o) Difompin
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- Explain the upward migration of enterocytes in colon. What is the role of Wnt factors and beta-catenin in the migration? Why does the mutation or absence of APC result in cancer?What is the pharmacodynamics that elevates the INR in a patient taking Warfarin and Motrin together?Which experiments support the hypothesis that GLP-1 is directly involved in improvement of glycemia in gastric bypass in animal and humans?
- What changes would you expect to observe in the liver at the tissue level of a patient with a chronic viral infection? what are the long term implications for the patient if left untreated and how would this affect tissue function?What is HbA1c? How does it differ from fasting blood glucose?Describe how chymotrypsin is activated via a cascade mechanism in the gut. How does it incorporate a positive feedback loop?How does it protect against acute pancreatitis?
- Which of the following types of drugs will have maximum oral bioavailability?A. Drugs with high first-pass metabolism.B. Highly hydrophilic drugs.C. Largely hydrophobic, yet soluble in aqueous solutions.D. Chemically unstable drugs.E. Drugs that are P-glycoprotein substrates.What function of liver involves the conjugation of bilirubin?A patient with H. pylori infection develops a gastric ulcer and is treated with omeprazole. Which of the following is/are mechanism(s) of action of omeprazole? Group of answer choices Inhibition of ACh action on parietal cells stimulation of somatostatin action on parietal cells inhibition of CCKb receptors inhibition of H+-K+ ATPase inhibition of Na+-K+ ATPase.
- A patient came to a dental clinic with complaints of dry mouth and multiple dental caries lesions. In the course of collecting anamnesis, it was found that an allergic patient takes antihistamines that block the H2 histamine receptors of smooth muscle cells of the salivary glands. It is known that histamine is a mediator that stimulates the secretion of saliva. Explain the mechanism of action of these drugs if it is known that the next day after discontinuation of the drug, the patient's dryness disappeared. Q: give a picture illustrating the action of this type of inhibitors.A patient came to a dental clinic with complaints of dry mouth and multiple dental caries lesions. In the course of collecting anamnesis, it was found that an allergic patient takes antihistamines that block the H2 histamine receptors of smooth muscle cells of the salivary glands. It is known that histamine is a mediator that stimulates the secretion of saliva. Explain the mechanism of action of these drugs if it is known that the next day after discontinuation of the drug, the patient's dryness disappeared. Q: what type of inhibitor the drugs are taken by? what is their classification according to the mechanism of action?A patient came to a dental clinic with complaints of dry mouth and multiple dental caries lesions. In the course of collecting anamnesis, it was found that an allergic patient takes antihistamines that block the H2 histamine receptors of smooth muscle cells of the salivary glands. It is known that histamine is a mediator that stimulates the secretion of saliva. Explain the mechanism of action of these drugs if it is known that the next day after discontinuation of the drug, the patient's dryness disappeared. For this: а) write the classification of inhibitors according to the mechanism of action b) indicate what type of inhibitors the drugs are taken by the patient; confirm your conclusion in writing c) guess what structure this drug may have d) give a picture illustrating the action of this type of inhibitors.