Which of the following epidermal growth factor (EGF) receptors cannot bind ligands but will form heterodimers with other EGFs? O HER2 (mouse Erb2) O HER3 (mouse Erb3) O HER1 (mouse Erb1) O HER4 (mouse Erb4)

Which of the following epidermal growth factor (EGF) receptors cannot bind ligands but will form heterodimers with other EGFs? O HER2 (mouse Erb2) O HER3 (mouse Erb3) O HER1 (mouse Erb1) O HER4 (mouse Erb4)

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter9: Cell Communication

Section: Chapter Questions

Problem 12RQ: Histamine binds to the H1 G-protein-linked receptor to initiate the itchiness and airway...

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Concept explainers

Cell Signaling

It allows cells to perform various cellular activities, coordinate, and interact with other cells. All cells of an organism receive signals from their environments and respond accordingly. Even the unicellular eukaryotes receive signals secreted by other cells and respond. In the case of yeast, mating takes place by signaling between the yeast cells. Communication by cell signaling in a multicellular organism has become a vast and important part of various fields of biology.

Question

Which of the following epidermal growth factor (EGF) receptors cannot bind ligands but will form heterodimers
with other EGFs?
O HER2 (mouse Erb2)
HER3 (mouse Erb3)
O HER1 (mouse Erb1)
O HER4 (mouse Erb4)

Expert Solution

Step 1

Epidermal growth factor (EGF) is a protein that plays a key role in the regulation of cell growth, proliferation, and differentiation. It is a member of the EGF family of growth factors that includes several other proteins with similar structures and functions. EGF acts by binding to and activating its receptor, the epidermal growth factor receptor (EGFR), which is a transmembrane protein with intrinsic kinase activity that can initiate downstream signaling pathways.

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