Which of the following illustrates the regulative nature of early mouse development? (a) the mouse embryo is freeliving prior to implantation in the uterus (b) it is possible to produce a transgenic mouse (c) it is possible to produce a mouse in which a specific gene has been knocked out(d) genes related to Drosophila homeotic genes have been identified in mice (e) a chimeric mouse can be produced by fusing two mouse embryos

Which of the following illustrates the regulative nature of early mouse development? (a) the mouse embryo is freeliving prior to implantation in the uterus (b) it is possible to produce a transgenic mouse (c) it is possible to produce a mouse in which a specific gene has been knocked out(d) genes related to Drosophila homeotic genes have been identified in mice (e) a chimeric mouse can be produced by fusing two mouse embryos

Biology (MindTap Course List)

11th Edition

ISBN:9781337392938

Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg

Publisher:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg

Chapter17: Developmental Genetics

Section: Chapter Questions

Problem 12TYU

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Discuss how the anterior portion of the anteroposterior axis is established in Drosophila. What aspects of oogenesis are critical in establishing this axis? What do you think would happen if the bicoid mRNA was not trapped at the anterior end but instead diffused freely throughout the oocyte?
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If a fertilized Drosophila egg is punctured at the anterior end and a small amount of cytoplasm is allowed to leak out, what will be the most likely effect on the development of the fly embryo?
Compare and contrast how maternal-effect genes, gap genes, and homeotic genes affect Drosophila development.
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Another way to study the role of proteins (e.g., transcription factors) that function in development is to microinject the mRNA that encodes a protein, or the purified protein itself, into an oocyte or embryo, and then determine how this affects the subsequent development of the embryo, larva, and adult. For example, if Bicoid protein is injected into the posterior region of an oocyte, the resulting embryo will develop into a larva that has anterior structures at both ends. Based on your understanding of the function of each developmental gene, what would be the predicted phenotype if the following proteins or mRNAs were injected into normal oocytes? A. Nanos mRNA injected into the anterior end of an oocyte B. Antp protein injected into the posterior end of an embryo C. Toll mRNA injected into the dorsal side of an early embryo
Discuss the role of homeotic genes in development. Explain what happens to the phenotype of a fruit fly when a gain-of-function mutation in a homeotic gene causes the protein to be expressed in an abnormal region of the embryo. What are the consequences of a loss-of-function mutation in such a gene?
Name three possible factors contributing to early asymmetries in a developing embryo (i.e. what are the kinds of things early on that lead to the development of the body axes - dn, a/p, l/r, etc)? In the fruit fly drosophila melanogaster, the anterior-to-posterior body axis becomes segmented into distinct regions. explain the role of the genes bicoid and nanos in this process.
In the late 1980s, this gradient hypothesis was united with a genetic approach to the study of Drosophila embryogenesis. If there were gradients, what were the morphogens whose concentrations changed over space?
Explain the functional roles of maternal-effect genes, gap genes, pair-rule genes, and segment-polarity genes in Drosophila development.
In recent years, techniques have been developed to clone mammals through a process called nuclear transfer, in which the nucleus of a somatic cell is transferred to an egg cell from which the nuclear material has been removed . Research has demonstrated that when a nucleus from a differentiated somatic cell is transferred to an eggcell, only a small percentage of the resulting embryos complete development, and many of those that do die shortly after birth. In contrast, when a nucleus from an undifferentiated embryonic stem cell is transferred to an egg cell, the percentage of embryos that complete development is significantly higher (W. M. Rideout, K. Eggan, and R. Jaenisch. 2001. Science 293:1095–1098). Propose a possible reason for why a higher percentage of cloned embryos develop successfully when the nucleus transferred comes from an undifferentiated embryonic stem cell.
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