Which of the following is NOT a involved in the CD8-T-cell killing of viral-infected cells? Select one: a. Recognition of the MHC Class I and viral-derived peptide on the surface of the target cell Ob. Reorientation of the intracellular cytoskeleton to move the cytotoxic granules toward the SMAC C. Release of perforin and granzymes onto the infected target cell d. Induction of apoptosis in the target cell by cleaving the nuclear DNA. Oe. Costimulation of CD8-T-cells with CD28/B7

Which of the following is NOT a involved in the CD8-T-cell killing of viral-infected cells? Select one: a. Recognition of the MHC Class I and viral-derived peptide on the surface of the target cell Ob. Reorientation of the intracellular cytoskeleton to move the cytotoxic granules toward the SMAC C. Release of perforin and granzymes onto the infected target cell d. Induction of apoptosis in the target cell by cleaving the nuclear DNA. Oe. Costimulation of CD8-T-cells with CD28/B7

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter42: The Immune System

Section: Chapter Questions

Problem 1VCQ: Figure 42.11 Which of the following statements about T cells is false? Helper T cells release...

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Figure 42.11 Which of the following statements about T cells is false? Helper T cells release cytokines while cytotoxic T cells kill the infected cell. Helper T cells are CD4+, while cytotoxic T cells are CD8+. MHC II is a receptor found on most body cells, while MHC I is a receptor found on immune cells only. The T cell receptor is found on both CD4+ and CD8+ T cells.
Of the following, which should NOT occur in order to facilitate T-cell selection in the thymus? A) positive-selection based on an interaction with MHC alone B) negative-selection based on a failed interaction with self-peptides in a MHC C) apoptosis of T-cells that fail to interact with MHC alone during positive selection. D) negative-selection based on an interaction with MHC containing a non-self peptide
Which of the following statements regarding CD4 is incorrect? a. MHC class II molecules present antigens to CD4 T cells. b. CD4 is the receptor used for HIV entry into CD4 T cells. c. CD4 is made up of two separate membrane-bound chains. d. Late in the progression of an HIV infection, the number of CD4 T cells in the circulation diminishes. e. CD4 is referred to as a T-cell co-receptor.
All of the following are characteristic of regulatory T cells except a. they express CD25 b. they facilitate the proliferation of naive T cells interacting with the same antigen-presenting cell c. they express CD4 d. they express the transcriptional repressor FoxP3 e. they express MHC class II-restricted T-cell receptors specific for self antigen.
Antibodies can have multiple mechanisms of action. The main mechanism is "flagging" a foreign body for phagocytosis and degradation. Another mechanism is... Select one: a. Binding of the Fc domain to T cells for cooperative antigen recognition and destruction. b. Altering the local pH by the formation of carbamate upon reaction with CO2 to denature protein antigens. c. Binding of the variable region to multiple different/distinct sites on the antigen. d. None of these. e. Binding of the antigen in regions essential for its function.
Which of the following explains why dendritic cells, but not macrophages or B cells, contribute to the activation of naive T cells? a. Macrophages and B cells do not express MHC class II molecules until they are activated. b. Dendritic cells upregulate B7 after engaging innate immunity receptors at sites of infection. c. Dendritic cells express higher levels of CTLA4. d. Macrophages and B cells do not process antigen. e. Dendritic cells use Toll-like receptors to hold antigen in place for extended periods of time.
MHC restriction is best described as a. elimination of thymocytes bearing T-cell receptors that are unable to interact with self-MHC molecules b. preferential survival and proliferation of thymocyes that survive negative selection c. T-cell recognition of a peptide antigen only when it is bound to a particular form of MHC molecule d. a state of non-responsiveness to a peptide antigen e. a condition in which either MHC class I or class II molecules are not expressed on cells.
Which of the following is part of the T-cell clonal deletion process? a) T-cells are eliminated if they bind to B-cells b) Lymphocytes that bind to MHC undergo apoptosis c) T-cells that bind to the same antigen as B-cells are eliminated d) Lymphocytes that react to autoantigens unde
The following events occur in humoral immunity, leading to an activated B cell in a T dependent manner. Of the steps listed below, which would be step number 5 in the process. Hint: only include these steps in the numbering...order the steps and select which one is #5 A. secretion of cytokines by Th B. Receptor mediated endocytosis C. B cell receptors recognize and bind to an antigen D. Recognition by Th E. Digestion and processing of the antigen by the B cell F. Display of the antigen along with MHC proteins
Which of the following statements regarding T cells activated by specific antigen is incorrect? a. They receive co-stimulatory signals through CD28. b. They suppress expression of sphingosine 1-phosphate (SIP). c. They take several days before differentiating into effector T cells. d. They cease to secrete and respond to interleukin-2 (IL-2). e. They begin to express CTLA4, which serves to limit T-cell proliferation.
Which of the following statements are true for antigen presentation. a. Antigen presentation means that other cells attach the pathogen first and present it to T cells. b. Antigen-presenting cells display protein fragments, resulting from the digestion of the pathogen, in complex with MHC receptor to B cells c. Antigen presenting cells display protein fragments, resulting from the digestion of the pathogen, in complex with MHC receptor on their surface. d. Antigen-presenting cells are phagocytic cells e. Antigen presentation is required for T cell activation f. Cytokines released by macrophages are required for T cell activation g. T cell receptors recognize the MHC receptors in complex with antigen fragments displayed by antigen-presenting cells. h. Phagocytic cells are involved in innate immunity. Therefore they have no role in T-cell activation
The diagram shows a pathogen (in red) that is present in different cellular compartments of each of the cell types shown. In each case, a specific T cell subset will recognize peptides of that pathogen presented on MHC molecules on the surface of the cell, and will execute its effector function. From the list below, match the appropriate T cell effector response to the cell type and location of the pathogen. CD4 T cell killing of target cell CD8 T cell killing of target cell CD4 T cell activation of target cell’s antibody production CD8 T cell activation of target cell’s antibody production CD4 T cell activation of target cell’s ability to kill intracellular pathogen CD8 T cell activation of target cell’s ability to kill intracellular pathogen