Which of the following is thought to be cause of  muscular fatigue? Decrease level of lactate within the muscle cell Decrease level of extracellular potassium outside of muscle cell Increased level of acetylcholinesterase in the synaptic cleft  Increase level of intracellular ATP within muscle cell Increase level of phosphate within muscle cell

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Which of the following is thought to be cause of  muscular fatigue?

Decrease level of lactate within the muscle cell

Decrease level of extracellular potassium outside of muscle cell

Increased level of acetylcholinesterase in the synaptic cleft 

Increase level of intracellular ATP within muscle cell

Increase level of phosphate within muscle cell

Expert Solution
Step 1: Introduction:

Muscle fatigue is the decrease in capacity of a muscle to create power. It very well may be a consequence of lively exercise however anomalous fatigue might be brought about by barriers to or impedance with the various phases of muscle constriction. There are two primary reasons of muscle fatigue: the limitations of a nerve's capacity to produce a continued signal (neural fatigue) and the diminished capacity of the muscle fiber to contract (metabolic fatigue).

Step 2: Options:

Increased levels of lactate or lactic acid cause muscle fatigue. Hence the first option is incorrect.

 

Increased level of extracellular potassium causes muscle fatigue. Hence the second option is incorrect.

 

Decreased levels of acetylcholinesterase in the synaptic cleft causes muscle fatigue. Hence the third option is incorrect.

 

Decreased levels of intracellular ATP within muscle cells cause muscle fatigue. Hence the fourth option is incorrect.

 

Inorganic phosphate (Pi), which increases during fatigue due to breakdown of creatine phosphate, appears to be a major cause of muscle fatigue. Hence the fifth option is correct.

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