Which of the following statements about innate lymphoid cells is true? (ONE ANSWER) Require the transcription factor IL-7 for development and express MHC-II Require the transcription factor ID2 for development and produce different cytokines depending on the ILC subset (ILC1, ILC2, or ILC3) Are considered part of the adaptive immune system Express lymphocyte antigen receptors that require V(D)J recombination Are derived from common innate progenitor (CIG) cells

Which of the following statements about innate lymphoid cells is true? (ONE ANSWER) Require the transcription factor IL-7 for development and express MHC-II Require the transcription factor ID2 for development and produce different cytokines depending on the ILC subset (ILC1, ILC2, or ILC3) Are considered part of the adaptive immune system Express lymphocyte antigen receptors that require V(D)J recombination Are derived from common innate progenitor (CIG) cells

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter42: The Immune System

Section: Chapter Questions

Problem 1VCQ: Figure 42.11 Which of the following statements about T cells is false? Helper T cells release...

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Figure 42.11 Which of the following statements about T cells is false? Helper T cells release cytokines while cytotoxic T cells kill the infected cell. Helper T cells are CD4+, while cytotoxic T cells are CD8+. MHC II is a receptor found on most body cells, while MHC I is a receptor found on immune cells only. The T cell receptor is found on both CD4+ and CD8+ T cells.
Which of the following is not a part of innate immunity? a. phagocytic cells e. inflammation b. fever f. complement activation c. histamines g. presenting antigen d. cytokines h. all take part
Which of the following is NOT true of Innate Lymphoid Cells (ILCs)? A) Each ILC type responds to a different category of pathogens. b.)) ILCs are derived from the common lymphoid precursor. c. )) ILCs rearrange their antigen receptors in a similar way to T-cells. d. ))Each ILC type is distinguished by the cytokines that it produces. e. ))Development of each ILC type is driven by unique transcription factors.
The emphasis in innate immunity is that it is non-specific. Explain how two different factors/parts of the human innate immune system are not specific to a particular pathogen.” “2. Antibodies are a crucial part of adaptive immunity. Discuss the structure of an antibody and how the adaptive immune system is capable of producing different antibodies for a wide variety of antigens.” “3. The innate and adaptive immune systems typically communicate with each other. Which system acts first and then communicates with the other? Why would this be advantageous?
Which of the following explains why dendritic cells, but not macrophages or B cells, contribute to the activation of naive T cells? a. Macrophages and B cells do not express MHC class II molecules until they are activated. b. Dendritic cells upregulate B7 after engaging innate immunity receptors at sites of infection. c. Dendritic cells express higher levels of CTLA4. d. Macrophages and B cells do not process antigen. e. Dendritic cells use Toll-like receptors to hold antigen in place for extended periods of time.
Which of the following statements are NOT TRUE about Antigen Presenting Cells (APCs)? (Select all that apply) An APC can become activated from antigen binding as well as MHC binding APCs can carry mutliple MHCs Antigen presenting is due to APC activation Adaptive, innate, and non-immune cells can be APCs APCs travel to the sites of resident macrophages to recruit effector immune cells An APC that binds via their expressed MHC II will be killed
All of the following statements regarding immunoglobulin gene rearrangement are true except a. Non-B cells retain their chromatin containing the immunoglobulin loci in a ‘closed’ configuration. b. T-cells never transcribe immunoglobulin genes. c. There is only one promoter on the heavy-chain locus that is 5ʹ of the V segments. d. Pax-5, a transcription factor, interacts with enhancer sequences positioned 3ʹ of the heavy-chain C-region genes. e. Transcription of immunoglobulin loci precedes gene rearrangement.
Which of the following statements regarding TLR4 is false? (Select all that apply.) a. TLR4 is a Toll-like receptor expressed by macrophages, but not by NK cells. b. TLR4 is an example of a phagocytic receptor. c. TLR4 associates with CD14, which acts as a co-receptor to TLR4. d. The ligand for TLR4 is lipopolysaccharide (LPS). e. TLR4 is expressed as a homodimer on the cell surface. f. The extracellular domain of TLR4 associates with soluble MD2. g. TLR4 does not contain a cytoplasmic TIR domain.
The following events occur in humoral immunity, leading to an activated B cell in a T dependent manner. Of the steps listed below, which would be step number 5 in the process. Hint: only include these steps in the numbering...order the steps and select which one is #5 A. secretion of cytokines by Th B. Receptor mediated endocytosis C. B cell receptors recognize and bind to an antigen D. Recognition by Th E. Digestion and processing of the antigen by the B cell F. Display of the antigen along with MHC proteins
Which of the following is true about innate immune system? Check all that apply. Rig-I-like receptors have the advantage of recognizing viruses by interacting with their spike proteins TLR signaling includes NF-kB pathways to induce synthesis of proinflammatory cytokines TLR binds to dsDNA or ssRNA to induce interferon gene expression PRR induced secretion of proinflammatory cytokines and chemokines have local and systemic effects PRR induces innate immunity; phagocytosis, inflammation, type I interferon production, and regulate adaptive immunity; DC maturation, costimulatory molecules, type I interferon
The major histocompatibility complex (MHC) (a) consists of Y-shaped molecules (b) encodes certain antibodies (c) encodes Toll-like receptors (d) inhibits complement release from macrophages (e) encodes a group ofcell-surface proteins.
Any aspect of the immune system can be deficient. Which of the following deficiencies would primarily affect the BARRIER function of immunity? Group of answer choices A. Complement Deficiencies, in which a variety of complement proteins do not function properly B. DiGeorge Syndrome, in which the thymus does not develop properly C. Selective IgA deficiency, in which IgA antibodies are produced in very low amounts D. Severe Combined Immune Deficiency (SCID), in which all T and B cell functions are absent