Which of the following statements correctly describes the function of a CD4 T-cell? (Level of difficulty: moderate) O CD4 T-cells are activated after interacting with any body cell, presenting antigen using a MHCI molecule. Once activated the CD4 cell releases cytokines to direct the required immune response. O CD4 T-cells are activated after interacting with a macrophage or dendritic cell, presenting antigen using a MHCII molecule. Once activated the CD4 cell will proliferate, interact with a B-cell and direct the immune response to the pathogen.

Which of the following statements correctly describes the function of a CD4 T-cell? (Level of difficulty: moderate) O CD4 T-cells are activated after interacting with any body cell, presenting antigen using a MHCI molecule. Once activated the CD4 cell releases cytokines to direct the required immune response. O CD4 T-cells are activated after interacting with a macrophage or dendritic cell, presenting antigen using a MHCII molecule. Once activated the CD4 cell will proliferate, interact with a B-cell and direct the immune response to the pathogen.

BIOLOGY:CONCEPTS+APPL.(LOOSELEAF)

10th Edition

ISBN:9781305967359

Author:STARR

Publisher:STARR

Chapter34: Immunity

Section: Chapter Questions

Problem 16SA: Match the immunity concept with the best description. ___anaphylactic shock a. recognizes antigen...

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Distinguish between a. neutrophil and macrophage b. cytotoxic T cell and natural killer cell c. effector cell and memory cell d. antigen and antibody
Figure 42.11 Which of the following statements about T cells is false? Helper T cells release cytokines while cytotoxic T cells kill the infected cell. Helper T cells are CD4+, while cytotoxic T cells are CD8+. MHC II is a receptor found on most body cells, while MHC I is a receptor found on immune cells only. The T cell receptor is found on both CD4+ and CD8+ T cells.
Match the immunity concept with the best description. ___anaphylactic shock a. recognizes antigen ___immune memory b. inadequate immune response ___autoimmunity c general defense mechanism ___inflammation d. immune response against ones own body ___immune deficiency e. secondary response ___antigen receptor f. acute allergic reaction ___antigen processing g. presenting antigen together with MHC markers
Which of the following statements are true for antigen presentation. a. Antigen presentation means that other cells attach the pathogen first and present it to T cells. b. Antigen-presenting cells display protein fragments, resulting from the digestion of the pathogen, in complex with MHC receptor to B cells c. Antigen presenting cells display protein fragments, resulting from the digestion of the pathogen, in complex with MHC receptor on their surface. d. Antigen-presenting cells are phagocytic cells e. Antigen presentation is required for T cell activation f. Cytokines released by macrophages are required for T cell activation g. T cell receptors recognize the MHC receptors in complex with antigen fragments displayed by antigen-presenting cells. h. Phagocytic cells are involved in innate immunity. Therefore they have no role in T-cell activation
Which of the following statements regarding intraepithelial lymphocytes is false? (Select all that apply.) a. They comprise approximately 10% of the cells in the mucosal epithelium. b. They are composed of both CD4 and CD8 T cells. c. They are separated from the lamina propria by a basement membrane. d. They are activated effector T cells with a narrow range of antigen specificities. e. They do not include NK cells. f. They express the α4:β7 integrin that binds to E-cadherin on epithelial surfaces.
Which of the following explains why dendritic cells, but not macrophages or B cells, contribute to the activation of naive T cells? a. Macrophages and B cells do not express MHC class II molecules until they are activated. b. Dendritic cells upregulate B7 after engaging innate immunity receptors at sites of infection. c. Dendritic cells express higher levels of CTLA4. d. Macrophages and B cells do not process antigen. e. Dendritic cells use Toll-like receptors to hold antigen in place for extended periods of time.
Which of the following are TRUE of class I major histocompatibility complex (MHC) molecules? a. Class I MHC molecules present endogenous antigens. b. Class I MHC molecules are only present on erythrocyte surfaces. c. Class I MHC molecules bind complement. d. Class I MHC molecules present exogenous antigens.
Which of the following is true about antigen presentation, MHC involvement or T cell activation? Check all that apply. A. TCR on CD8 T cells recognizes MHC II-peptide complexes as signal 1 for T cell activation B. Signal 2 and 3 for T cell activation involve interaction of B7.1/B7.2 (CD80/CD86) on APC with CD28 on T cells and cytokine release, respectively C. Many cell types express MHC I and load antigen on it, whereas professional APC present antigen loaded on MHC II D. CD4 interacts with MHC II and CD8 with MHC I for antigen presentation by APC E. TCR on CD4 T cells recognizes MHC II-peptide complexes as signal 1 for T cell activation
A patient has contracted an upper respiratory infection caused by a virus. Her initial adaptive immune response to the virus is due to what mechanism of immune surveillance?a. The display of viral antigens by naïve B-cells on class I MHC, which is then recognized by helper T-cells that then activate cytotoxic T-cells.b. The display of viral antigens on class I MHC, which is then displayed to sensitized naïve B-cells, leading to the production of antibodies.c. The display of viral antigens on class II MHC by a sensitized naïve B-cell, which is then activated by a helper T-cell primed to the same antigen to begin producing antibodies.d. The display of viral antigens on class I MHC, which is then displayed to helper T-cells, leading to the activation of naïve cytotoxic T-cells.
MHC class I molecules present peptide antigens derived from a(n) _______ compartment, whereas MHC class II molecules present peptide antigens derived from a(n) _______ compartment: a. extracellular; intracellular b. intracellular; extracellular c. opsonization; neutralization d. neutralization; opsonization e. none of the above.
Which of the following statements is NOT correct? Group of answer choices -Natural killer cells are cytolytic lymphocytes that mediate ADCC -Neutrophils carry out phagocytosis of C3b-tagged particles -Macrophages carry out phagocytosis of C3b-tagged particles -Mast cells produce granules containing the cytotoxin perforin -B lymphocytes express a receptor for complement proteins
Identify which of the following statements regarding naive T cells is incorrect. a. Naive T cells have the capacity to survive for many years as nondividing circulating cells in the absence of specific antigen. b. Naive T cells express LFA-1 molecules that change their conformation after encountering a specific peptide:MHC complex. c. Naive T cells exit from lymph nodes using the same route as effector T cells. d. Naive T cells express ICAM-3, which binds to DC-SIGN on dendritic cells with high affinity. e. Naive T cells express high levels of S1P receptors on their surface.