A patient has contracted an upper respiratory infection caused by a virus. Her initial adaptive immune response to the virus is due to what mechanism of immune surveillance?a. The display of viral antigens by naïve B-cells on class I MHC, which is then recognized by helper T-cells that then activate cytotoxic T-cells.b. The display of viral antigens on class I MHC, which is then displayed to sensitized naïve B-cells, leading to the production of antibodies.c. The display of viral antigens on class II MHC by a sensitized naïve B-cell, which is then activated by a helper T-cell primed to the same antigen to begin producing antibodies.d. The display of viral antigens on class I MHC, which is then displayed to helper T-cells, leading to the activation of naïve cytotoxic T-cells.

A patient has contracted an upper respiratory infection caused by a virus. Her initial adaptive immune response to the virus is due to what mechanism of immune surveillance?a. The display of viral antigens by naïve B-cells on class I MHC, which is then recognized by helper T-cells that then activate cytotoxic T-cells.b. The display of viral antigens on class I MHC, which is then displayed to sensitized naïve B-cells, leading to the production of antibodies.c. The display of viral antigens on class II MHC by a sensitized naïve B-cell, which is then activated by a helper T-cell primed to the same antigen to begin producing antibodies.d. The display of viral antigens on class I MHC, which is then displayed to helper T-cells, leading to the activation of naïve cytotoxic T-cells.

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter12: Body Defenses

Section: Chapter Questions

Problem 15RE

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Adaptive immunity includes both humoral and cell-mediated immune responses, which interact but also have distinct roles in adaptive immunity. Identify the example of a strictly cell-mediated immune response. A. A cytotoxic T cell destroys an infected host cell. B. A helper T cell activates a B cell. C. A B cell gives rise to plasma cells, which release antibodies. D. An antigen is taken in by an antigen-presenting cell.
Which of the following statements regarding T cells activated by specific antigen is incorrect? a. They receive co-stimulatory signals through CD28. b. They suppress expression of sphingosine 1-phosphate (SIP). c. They take several days before differentiating into effector T cells. d. They cease to secrete and respond to interleukin-2 (IL-2). e. They begin to express CTLA4, which serves to limit T-cell proliferation.
Explain why each choice (a-d) is correct or incorrect. T cells are differentiated into two groups based on their glycoproteins CD4 or CD8. Which of the following is true of CD4 T cells? a. They become cytotoxic T cells. b. The become antigen presenting cells. c. They become T helper cells. d. They become plasma cells.
Which event happens first during cytotoxic T-cell activation? a. Cytotoxic T cells secrete perforin and granzyme. b. Cytotoxic T cells recognize foreign antigen presented on the surface of a MHC I molecule. c. Cytotoxic T cells proliferate to form many new cells specific for the same antigen d. Cytotoxic T cells recognize foreign antigen presented on the surface of a TCR.
What distinguishes MHC I from MHC II? a-aquisition of antigenic peptide in the cytoplasm b-cross-presentation of antigegn to CD4 T cells c- presentation of peptides to the T cell receptor d-binding of a B-amino acid peptide e- presentation of antigenic peptides to CD4 T cells
Explain why each choice (a-d) is correct or incorrect. Which of the following examples below describes an autoimmune disease? a. Infection and death of T helper cells by a virus, resulting in a loss of adaptive immunity b. Release of bacterial endotoxins that block acetylcholine release result in muscle paralysis. c. Antibody binding to acetylcholine receptors of the motor end plate resulting in muscle weakness. d. Uncontrolled cell division resulting in cell surface abnormalities recognized by NK cells.
During the adaptive immune response, the role of helper T cells includes _____. Mark all that apply. Group of answer choices a. using CD8 to identify cells that are infected with pathogens b. facilitating clonal selection c. using CD4 to recognize antigen presenting cells d. activating mitosis in B cells e. auto-activation of mitosis (self-activating mitosis to produce more helper T and memory T cells) f.using T cell receptors to bind epitopes on pathogens
All of the following are true in reference to T-cell priming except _____. a. it occurs in primary lymphoid organs b. it transforms naive T cells into differentiated effector T cells c. it is the first stage of a primary adaptive immune response d. it requires interaction between naive T cells and antigen-presenting cells e. it takes place in many locations including, but not limited to, lymph nodes, Peyer’s patches, and the tonsils.
Which of the following is part of the T-cell clonal deletion process? a) T-cells are eliminated if they bind to B-cells b) Lymphocytes that bind to MHC undergo apoptosis c) T-cells that bind to the same antigen as B-cells are eliminated d) Lymphocytes that react to autoantigens unde
How is clonal selection related to the vast number of possible B and T-cell receptor binding conformations? Draw a picture to illustrate your explanation.
Activated helper T Cells participate in which of the following processes? a.) Differentiation of memory B cells b.) Activation of cytotoxic T Cells c.) Facilitation of macrophage phagocytosis d.) All of above
In a mixed lymphocyte reaction, T cells from individual A make a robust response to antigen-presenting-cells from individual B, as long as the two individuals express different alleles of MHC molecules. Estimates indicate that up to 10% of the T cells from individual A may contribute to this response. If one performed this assay using responder T cells from a child and antigen-presenting cells from one parent, the result would be: A massive proliferative response made by the antigen-presenting cells of the parent A very weak response by the child’s T cells, involving only 0.1% of their T cells The complete absence of any proliferative response by the child’s T cells A robust cytolytic response that kills all of the parent’s antigen-presenting cells A robust response by the child’s T cells