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Which ONE of the following is not taken into consideration when determining the ‘clinical breakpoint’?
The drug MIC distribution for the wild-type bacterial population
The
The drug Cmax value
Pharmacodynamical parameters
Elimination half-life of the drug
Step by step
Solved in 2 steps
- As an Environmental Engineer, a local health project requires you to use the Koch’s postulate to establish and ascertain the causative organism for the disease Tuberculosis in a given population. Provide a systematic and chronological blueprint of your plan to achieve this purpose.There are different types of sampling designs that may be used depending on the types of studies. Which sampling design you may recommend for the following experiments : a. To investigate the disease incidence in a field of tomato b. To investigate the nosocomial infection in people c. To investigate the microbial diversity in an agricultural fieldA medium was inoculated with 5 * 106 cells/ml of Escherichiacoli cells. Following a 1-h lag, the population grewexponentially for 5 h, after which the population was 5.4 * 109cells/ml. Calculate g and k for this growth experiment.
- the following are the steps, listed in random order, for utilizing koch's postulates. what should be the second step out of the four listed? a. a microorganism is found to be present in every case of a disease. b. the same microbe discovered previously is isolated from the purposely infected host c. the pathogen is isolated and grown in pure culture d. the same disease results after isolated organism is inoculated into healthy hostWhen determining the clinical significance of cultures, a. the number of microbes is signifi cant. b. the presence of a single colony of a true pathogen may indicate the presence of the disease if the culture comes from a site known to be sterile (i.e., cerebrospinal fl uid). c. the repeated isolation of a relatively pure culture of any microorganism can mean it is an agent of disease, although this is not always the case. d. a range of tests may be needed to identify a pathogen. e. all of the above are true.Different types of sampling designs are here that may be used depending on the types of studies. Which sampling design you may recommend for the following experiments : 1. To investigate the disease incidence in a field of tomato 2. To investigate the nosocomial infection in people 3. To investigate the microbial diversity in an agricultural field
- Which of the following is not part of Koch’s Postulates? a. A specific microorganism must be present in a disease b. The organism must be isolated into pure culture c. Living organisms spring forth from non-living materials d. All of the choices are part of Koch’s PostulatesIn the Kirby-Bauer test, which of the following must be consistent? a. concentration of bacteria placed on the plate b. type of medium in the plate c. concentration of antimicrobial drug in the disk d. all of theseWhich of the following is the most effective way to reduce the number of nosocomial infections? View Available Hint(s) for Part A limiting patient stays specimen collection antibiotic therapy handwashing
- propose a hypothesis regarding the organisms (staphylococcus, escherichia, pseudomonas, and bacillus) that will be resistant to the most disinfectants, and why? if the hypothesis is supported, what specific experimental results will be observed? what would be the independent and dependent variable? zone size, disinfectant type, colony countWhat are the research objectives and the hypothesis? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391019/Name two or more situations where Koch’s postulates are impossible to complete? In other words, what factors about a microbe or factors about a disease make it impossible for Koch's postulate to be performed with that microbe or disease?