Whole-exome sequencing (WES) is helping physicians diagnosea genetic condition that has defied diagnosis by traditionalmeans. The implication here is that exons in the nucleargenome are sequenced in the hopes that, by comparison withthe genomes of nonaffected individuals, a diagnosis might berevealed. What are the strengths and weaknesses of this approach?

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Genome annotation

The technique of linking biological information to genome sequences is termed genome annotation. Gene annotation is the method of identifying gene locations and coding sections. It helps us understand what these genes are doing in the body through establishing structural characteristics and linking them to the actions of various proteins.