Why and how do the polymerase go backward from state 2 (post-translocation state) to state 1(pre-translocation state) during replication and transcription?
Why and how do the polymerase go backward from state 2 (post-translocation state) to state 1(pre-translocation state) during replication and transcription?
Chapter5: Unit, Percentage, Milliequivalent, Ratio, And Household Measures
Section: Chapter Questions
Problem 2.7P
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Why and how do the polymerase go backward from state 2 (post-translocation state) to state 1(pre-translocation state) during replication and transcription?
Transcribed Image Text:km+/ niu
Product
Substrate(non-cognate/wrong)
IIIW
Err*kö-
(1-Err) KII-
km+
Err*k₁-
mini
(1-Err) K₁-
(1-i,) k₁+
i₁ kµ+
kun-in
Err*k₁+
(1-Err) KI+
III™
Substrate(cognate/right)
ki-
Reactant
Figure 1. The kinetic scheme for the three-state nucleotide addition cycle (NAC) with selection.
Since the cognate (right) and non-cognate (wrong) nucleotide species are differentiated in the
substrate state III, one splits the cycle into two pathways for the right and wrong substrate species.
Correspondingly, one has a population vector II : (P₁, P₁, P, PW) to describe the overall state
probability distributions.
=
III
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