Why is aneuploidy of the sex chromosomes less debilitating than aneuploidy of even the smallest autosomes? (Note: multiple responses are correct, please choose the best answer(s)) Select one or more: Only one X chromosome is required at any given time.  Additional X chromosomes (as in females) are inactivated in most cells except for gametes Dosage compensation requires that all excess chromosomes (i.e. 2 or more) are activated at all times during the cell cycle The Y chromosome carries a number of critical genes involved in spermatogenesis and sex development.  Therefore, having two copies of the Y chromosome results in the overproduction of sperm and increased fertility The Y chromosome carries a number of critical genes required for spermatogenesis and sex development, but very few other genes.  Therefore, having two copies of the Y chromosome has minimal impact on the balance of gene expression

Human Physiology: From Cells to Systems (MindTap Course List)
9th Edition
ISBN:9781285866932
Author:Lauralee Sherwood
Publisher:Lauralee Sherwood
Chapter20: The Reproductive System
Section: Chapter Questions
Problem 11RE
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Why is aneuploidy of the sex chromosomes less debilitating than aneuploidy of even the smallest autosomes?

(Note: multiple responses are correct, please choose the best answer(s))

Select one or more:
  • Only one X chromosome is required at any given time.  Additional X chromosomes (as in females) are inactivated in most cells except for gametes
  • Dosage compensation requires that all excess chromosomes (i.e. 2 or more) are activated at all times during the cell cycle
  • The Y chromosome carries a number of critical genes involved in spermatogenesis and sex development.  Therefore, having two copies of the Y chromosome results in the overproduction of sperm and increased fertility
  • The Y chromosome carries a number of critical genes required for spermatogenesis and sex development, but very few other genes.  Therefore, having two copies of the Y chromosome has minimal impact on the balance of gene expression
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