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- 3. Which stereoisomer can obtain the least amount of conformational strain, cis- or trans-1,3-dimethylcyclohexane? What is the difference in strain energy between these two mWhich of the four stereoisomers has the most stable conformation? Why?Which chair conformation of cis- and trans-1,4-dimethylcyclohexane has the lowest potenital energy? Which is the most stabel? Why?