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Subject: Neurophysiology
Would a skeletal muscle fire an AP if a single quanta of ACh was secreted? Why or why not?
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- Predict the consequence if presynaptic action potentials in an axonrelease insufficient acetylcholine to depolarize a skeletal muscle fiber tothreshold.In your own words, describe the main events occurring between the arrivalof an action potential at a motor neuron end plate and contraction of thecorresponding muscle. Use 250 words or less.Pharmacology: Provide examples of membrane transport in stroke, cell signaling (especially cell signaling) and homeostasis
- Subject: Neurophysiology Imagine a toxin that blocks voltage gated K channels. What do you expect to see at the neuromuscular junction when you stimulate the pre synaptic neuron? Would you release neurotransmitter? Would the skeletal muscle contract?Discuss the motor protein associated with the MF in detail, but do not include structure (include muscle and non-muscle) regarding cell BioArticle: Effect of Patterned Electrical Neuromuscular Stimulation on Vertical Jump in Collegiate Athletes This article presents research evidence regarding PENS (patterned electrical neuromuscular stimulation) and it’s effects on vertical jump of athletes. Please show a-e. a.) background b.) purpose c.) methods d.) results e.) conclusion Lastly, Reflect on the article. What did you learn? What made sense? What did you not understand or was confusing? What did you agree or disagree with? Do you have follow-up questions? How does this data apply to clinical practice? Will you clinically use this data?
- a. Define threshold potential. b. One student commented that the threshold potential for this muscle fibre is exactly 50 mV. Do you agree or disagree? Why or why not?Fill in the blank: The P wave corresponds to depolarization of the muscle fibers of the _______________________.Fasciculations of lower motor neuron lesions :-a- are caused by injury currents initiated in the denervated muscle fibersb- can be recorded by electromyogramc- consist of asynchronous contraction of the muscle fibers composing a motor unitd- develop later than fibrillations of the muscle fibers
- Order the following events of excitation and excitationcontraction coupling. Put 1 by the first event, 2 by the second, and so on._____ The motor end plate generates an end-plate potential._____ The action potential spreads along the T-tubules, SR calcium ion channels are pulled open, and calcium ions flood the cytosol._____ Acetylcholine binds to receptors on the motor end plate, and ligand-gated ion channels open._____ Calcium ions bind troponin, which allows tropomyosin to move away from the actin active site, initiating a contraction cycle._____ The action potential propagates through the sarcolemma and dives deeply into the cell along the T-tubules.Introduction to Neuroscience Movement1) Describe the generation of muscle force2) List the properties of the Neuro Muscular Junction (NMJ)Discuss the similarities and differences by which Ca2+ activity is involved in initiating muscle contraction in skeletal versus smooth muscle fibers (hint: include Ca2+ sources, proteins it binds to, and signaling cascade it activates leading to contraction). (max 12 sentences)
