You are evaluating toxicant A and need to determine its partition coefficient. To do this you place 14.00 grams of toxicant A into 150 ml of phospholipid and 150 ml of water. You determine 12 g partitions into the phospholipid layer and 2.00 g partitions into the water. Calculate the partition coefficient of toxicant A. P= Vw/Vo [Cwo-Cw/Cw] a) 5.10 b) 0.229 c) 4.36 d) 6.00

You are evaluating toxicant A and need to determine its partition coefficient. To do this you place 14.00 grams of toxicant A into 150 ml of phospholipid and 150 ml of water. You determine 12 g partitions into the phospholipid layer and 2.00 g partitions into the water. Calculate the partition coefficient of toxicant A. P= Vw/Vo [Cwo-Cw/Cw] a) 5.10 b) 0.229 c) 4.36 d) 6.00

Principles of Instrumental Analysis

7th Edition

ISBN:9781305577213

Author:Douglas A. Skoog, F. James Holler, Stanley R. Crouch

Publisher:Douglas A. Skoog, F. James Holler, Stanley R. Crouch

Chapter28: High-performance Liquid Chromatography

Section: Chapter Questions

Problem 28.2QAP

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The partition coefficient(k)of a substance between petroleum ether and water is 6. A substance of mass 12 g is dissolved in 50 mL of water. Calculate the total mass of sample that can be extracted into 40 mL of ether if the ether is used in two 20 mL portions.
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