Variation in volume of extraction solvent: compound X is dissolved in 20.0 mL of solvent B. Assuming a partition coefficient of PX,AB of 5.0, calculate the percentage of X that remains in solvent B if it is extracted the following volumes of solvent A: 1.0 mL 10.0 mL 20.0 mL 100.0 mL

Variation in volume of extraction solvent: compound X is dissolved in 20.0 mL of solvent B. Assuming a partition coefficient of PX,AB of 5.0, calculate the percentage of X that remains in solvent B if it is extracted the following volumes of solvent A: 1.0 mL 10.0 mL 20.0 mL 100.0 mL

Fundamentals Of Analytical Chemistry

9th Edition

ISBN:9781285640686

Author:Skoog

Publisher:Skoog

Chapter33: High-performance Liquid Chromatography

Section: Chapter Questions

Problem 33.5QAP

See similar textbooks

Related questions

Q: If the solubility of a drug is 3.8g/L and in chloroform 226g/L calculate its partition coefficient…

Q: Q: 1: The distribution constant for iodine between an organic solvent and H,0 is 85. Find the…

A: Hello. Since your question has multiple parts, we will solve the first question for you. If you want…

Q: Consider the chlorination (Cl2, hν) of optically active (2R,3R)-2-chloro-3-methylpentane. If the…

Q: c) diethyl ether. After separating the layers, 240 mg of cyclohexanol are recovered from the diethyl…

Q: Let the retention factor of species A be 0.5, while the retention factor of species B be 0.3. If…

A: Given Rf = Retention factor Rf(A) = 0.5 Rf(B) = 0.3 Distance travelled by solute A = 1.0 cm

Q: Two weak acids, HA and HB, have K4 values of 1.0 E-6 and 3.0 E-4. Their partition coefficients…

A: Given :-HA⇌H++A- Ka=1x10-6 KHA=12.2HB⇌H++B-Ka=3x10-4 KHB=8.3Ka=H+A-HA=A-HA=KaH+Distribution ratio…

Q: Q: 2: An acidic solute, HA, has an acid dissociation constant of 1.00 x10, and a partition…

A: Distribution ratio(D) is defined as the total concentration of components in stationary phase…

Q: The partition coefficient for caffeine between dichloromethane and water is 4.6. Assume that a 100…

A: The partition coefficient gives the proportion of the concentration of solute dissolved in two…

Q: (4113011 5. A monoprotic acid (HA) with K, of 8.76 x 10 has a partition coefficient of 3.9 (favoring…

A: 5#(a): The organic solvent used for extraction is octanol. Given the partition coefficient, P = 3.9…

Q: At 25 °C, the octanol-water equilibrium partition coefficient KOW of Compound X is 150,000 and its…

A: Given that the first equilibrium exists between octanol and water.

Q: Two species A and B are known to have water/hexane partition coefficient of 5.99 and 6.16. They are…

Q: In carbonate mixtures, Vpth > ½Vbcg for an NaOH, N22CO3 mixture. Try to explain why the relationship…

A: We need to explain the relative volume of acid used up in titration of the mentioned mixture of…

Q: Benzene is one of the Toxic Air Pollutants (TAPS) found in car exhaust fumes When a 50.00 ml.…

A: It is given that the fractional distillation of 50.00 mL of aqueous solution of 0.05000 M benzene is…

Q: Q: 2: An acidic solute, HA, has an acid dissociation constant of 1.00 x10-, and a partition…

A: The extraction efficiency of acidic solute easily determines with the help of the distribution…

Q: 15 Asolution of butanedioic acid (BDA) in ether contains 0.034 mol of BDA in 20 cm³ of ether. This…

A: Given data = Total no of moles of BDA in ether before shaking = 0.034 mole moles of BDA in water…

Q: Amphetamine is a weak base, pKa is 9.9, has a partition coefficient of 50 when distributed between…

Q: A mixture of I, II, and II were partitioned between methylene chloride and sodium bicarbonate (A).…

A: Step 1: Mixture of compounds are treated with NaHCO3. Compound III will go into aqueous layer. Step…

Q: Why are collision cells a necessary addition to mass spectrometers that employ electrospray…

A: In mass spectrometers that employ electrospray ionization, a major challenge is how one can fragment…

Q: You have 150 mL of 0.25 M n-propylamine and you shake this in a mixture of 90 mL of water and 50 mL…

A: A question based on general chemistry that is to be accomplished.

Q: It can be shown mathematically that 2 or more smaller extractions (using smaller portions of a…

Q: An unknown substance “A" was allowed to partition between a mixture of 150 mL water and 80 mL…

A: Partition coefficient =Concentration of A in benzeneConcentration of A in toluene…

Q: A 50 ml aqueous sample containing 0.015 M amine (Ka = 3.16 x 10-9) was adjusted to pH 9.0 and then…

A: Liquid - liquid extraction

Q: Please define the term distribution coefficient, Kd? 2) How the value of Kd indicates the…

Q: If the solubility of a drug is 3.8 g/L and in chloroform 224.9 g/L calculate its partition…

A: Solubility of drug in water = 3.8 g/L Solubility of drug in chloroform = 224.9 g/L

Q: When gypsum (CaSO4 2H2O) is heated to 433 K, it converts to the hemihydrate CaSO4 1 2H2O, and at…

Q: A neutral compound has a partition coefficient of 7 between ether and water. What percentage of the…

A: Partition coefficient (K) = Kether/ Kwater = 7 Let initial amount f substance = W gram After…

Q: When ionic bromination of cyclohexene is carried out, the product is trans-1,2-dibromocyclohexane.…

A: When ionic bromination of cyclohexene is carried out, the product is trans-1,2-dibromocyclohexane.…

Q: Distance travelled by solvent: 5.50cm TCL pure caffeine Distance travelled by the component: 2.20cm…

A: The retention factor or the Retardation factor or in other words delay factor is a ratio of the…

Q: 2. If 6 g of phenol (weak acid, pKa 9.9) is distributed between 100 mL of an aqueous buffered…

Q: Iodine is being extracted from 200 mL water using 50 mL CCl4. The partition coefficient for I2 being…

A: Solvent extraction: If V mL of a solution containing W gram of solute to be repeatedly extracted…

Q: Fill in the blank. In solvent extraction, the value of partition coefficient should be ________ in…

A: Solvent extraction is performed for extraction process in which a compound transfer from one…

Q: A 78 mg sample of an organic compound (molar mass = 84.0 g/mol) is partitioned between 2.00 mL of…

A: We calculate in grams/mL. Remember that 1mL = 1cm3So, 78 mg (1g/1000mg) =0.078g initial sample…

Q: A novel compound named “sanaoline” with a partition coefficient (KD) of 6 was extracted from 5.0…

A: Formula for partition coefficient w = W[KD V/(KDV +v)]n Where w is reaming amount of sanaoline = ?…

Q: The solubility of Lorazepam (a tranquilizer found in Emotival , Lorax, Wypax, and other prescription…

A: “Since you have asked multiple question, we will solve the first question for you. If youwant any…

Q: Two compounds with partition coefficients of 15 and 18 are to be separated on a column with…

A: The formula to calculate the number of theoretical plates are, R=N4α-1αkB1+kB Where, R= Resolution…

Q: Briefly explain how analytes are separated using the following modes of chromatography.…

A: Chromatography is a process in which a chemical mixture is carried by a liquid or gas as medium is…

Q: 1.0 g of a compound A is prepared in 100 mL of water, and then extracted with 50 mL of ether. After…

A: Initially 1 g of compound A was present in the water. And finally the ether is extracting 0.25 g of…

Q: A neutral compound has a partition coefficient of 8 between ether and water. What percentage of the…

A: Nernst distribution law: if a solute X distributes itself between two immiscible solvents A and B at…

Q: Which of the following are the three main factors affecting the rate of movement of a compound on a…

A: When a compound is converted into its vapor form and the pressure exerted by its vapor is known as…

Q: Your group was allocated an unknown substance X and instructed to measure its partition coefficient…

A: given - 4 grams of X are dissolved and shaken in a combination of 130 mL benzene and 100 mL water.…

Q: The following equation describes the dependence of the rate constant (k) with the temperature in…

A: Let's us suppose a equation, K = e -x Now if we increase the value of x, the value of e -x will…

Q: One gram of a compound requires the following quantities of solvent to dissolve: 47 ml of water, 8.1…

Q: How do you find the Ksp and solubility limit for SrSO4 given [Sr]=0.000583095 & [SO4]=0.000583095?

Q: will addition of 300ml 0.005M agno3 to 200ml of 0.004M Al2(SO4)3 result in oreciptation of Ag2SO4 if…

A: Given, Volume of AgNO3 in mL = 300 mL Molarity of AgNO3 = 0.005 M Volume of Al2(SO4)3 = 200 mL…

Q: The absorbance of a 0.5 mM aqueous salicylic acid solution was 0.925. This solution was extracted…

Question

Variation in volume of extraction solvent: compound X is dissolved in 20.0 mL of solvent B.

Assuming a partition coefficient of

PX,AB of 5.0, calculate the percentage of X that remains in

solvent B if it is extracted the following volumes of solvent A:

1.0 mL

10.0 mL

20.0 mL

100.0 mL

Expert Solution

Given Data:

$\cdot Volume of Solvent (V_{B}) = 20.0 mL \cdot Partition coefficient (P_{X \cdot AB}) = 5.0 \cdot Volumes of Solvent A (V_{A}) are = \cdot 1.0 mL \cdot 10.0 mL \cdot 20.0 mL \cdot 100.0 mL We need to calculate the percentage of " X " that remains in solvent B$

Trending now

This is a popular solution!

Step by step

Solved in 3 steps with 1 images

SEE SOLUTION Check out a sample Q&A here

Knowledge Booster

Learn more about

Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.

Similar questions

The partition coefficient K for a compound between dichloromethane and water is determined to be 56 : 1 (K=56). If 10.0 mg of the compound is dissolved in 50.0 mL of water and this solution extracted with 25.0 mL of dichloromethane, how many mg of the compound will remain in the water layer following the extraction procedure? Show you calculations
The partition coefficient(k)of a substance between petroleum ether and water is 6. A substance of mass 12 g is dissolved in 50 mL of water. Calculate the total mass of sample that can be extracted into 40 mL of ether if the ether is used in two 20 mL portions.
Solute S has a partition coefficient of 4.0 between water (phase 1)and chloroform (phase 2) in K = AS2/AS1= [S]2/[S]1(a) Calculate the concentration of S in chloroform if [S(aq)] is 0.020 M.(b) If the volume of water is 80.0 mL and the volume of chloroformis 10.0 mL, find the quotient (mol S in chloroform)/(mol S in water).
The absorbance of a 0.5 mM aqueous salicylic acid solution was 0.925. This solution was extracted with 10% ethyl acetate/hexane solution. The absorbance of the extracted aqueous salicylic acid solution at equilibrium was 0.670. Find the equilibrium concentrations of SA in the aqueous and the non-aqueous phases. Calculate the partition coefficient (K) for the salicylic acid.
The solubility of Lorazepam (a tranquilizer found in Emotival , Lorax, Wypax, and other prescription medicines) is 0.08mg/mL and 2.62mg/mL, in water and chloroform, respectively. Estimate the partition coefficient of lorazepam between chloroform and water. 3. The solubility of benzoic acid at 25 degrees Celsius in water and diethyl ether is 3.35 mg/mL and 0.353 g/mL, respectively. Estimate the percent recovery of benzoic acid in the organic phase, if a solution of benzoic acid in water is extracted with an equivalent volume of ether. [HINT-pay attention to the units] 4. The solubilities of cholesterol in water and chloroform are 0.550mg/100mL and 1.00g/5.25mL, respectively. Estimate the partition coefficient of cholesterol between chloroform and water. [HINT- units] What conclusion can be drawn about the polarity of cholesterol?
Iodine is being extracted from 200 mL water using 50 mL CCl4. The partition coefficient for I2 being extracted from water into CCl4 is 85. i. Calculate the extraction efficiency when the CCl4 is used in one portion. ii. Show how the extraction efficiency is improved if the solvent is used in two portions.
Explain why the partition coefficient of salicylic acid is different when a solution of 0.01 M HCl in water (pH ~ 2.0) is used as the aqueous layer compared to when just water (pH ~ 7) is used.
The absorbance of a 0.5 mM aqueous salicylic acid solution was 0.925. This solution was extracted with 10% ethyl acetate/hexane solution. The absorbance of the extracted aqueous salicylic acid solution at equilibrium was 0.670. a. Find the equilibrium concentrations of SA in the aqueous and the non-aqueous phases. b. Calculate the partition coefficient (K) for the salicylic acid.
A 78 mg sample of an organic compound (molar mass = 84.0 g/mol) is partitioned between 2.00 mL of water and 2.00 mL of methylene chloride. Separation and processing of the organic phase results in the isolation of 58 mg of the organic compound. Calculate the partition coefficient for the compound between methylene chloride and water (Kpmethylene chloride/water). Your answer should reflect the proper number of significant figures.
Chemistry A 50ml aliquot of a 0.1 M solution of a neutral drug was extracted with 2 x 5 ml ethyl acetate. The drug concentration in the combined organic layers was found to be 0.36 M. Calculate the partition coefficient for this drug under these conditions.
The partition coefficient for caffeine between dichloromethane and water is 4.6. Assume that a 100 mL tea solution (in water) contained 100 mg of caffeine. What is the theoretical yield of caffeine in the methylene chloride if you extract with one 100 mL portion of methylene chloride?
A solute is added to a water- benzene mixture and mixture and shaken vigorously. 25ml benzene layer contains 0.1g solute and 25ml water layer contains 0.25g solute. What is the value of distribution coefficient or partition coefficient?