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You are studying SARS-COV2. You identify a viral protein that results in the decrease of MHC class I, a cell surface receptor, on the cell surface. You are trying to determine the mechanism for how the virus is decreasing cell surface MHC I. You decide to do an experiment to determine whether the receptor is making it all of the way through the secretory pathway. You take two samples of cells. 1. Uninfected 2. Infected with SARS-COV2 You treat them with EndoH and analyze MHC I on a western blot and get the following results: 1. Uninfected cells - 50% of protein is endo H sensitive and 50% is Endo H resistant 2. SARS-COV2 infected cells - 100% of protein is Endo H sensitive How would you best interpret these results? Is MHC I going all the way through the secretory pathway in infected cells? O A. No, MHC I is not going all the way through the secretory pathway. 100% of the protein is EndoH sensitive in infected cells, this means that the virus is somehow inhibiting the protein from making it through the Golgi. O B. No, MHC I is not going all the way through the secretory pathway. Only 50% of the protein is EndoH resistant in infected cells, this means that the virus is somehow inhibiting half of the protein from making it through the Golgi. O. Yes, MHC l is going all the way through the secretory pathway. 100% of the protein is EndoH sensitive in infected cells. This means that the virus has no effect on the protein from making it through the Golgi. O D. No, MHC I is not going all the way through the secretory pathway. Only 50% of the protein is EndoH resistant in uninfected cells, this means that the virus is somehow inhibiting half of the protein from making it through the Golgi.

You are studying SARS-COV2. You identify a viral protein that results in the decrease of MHC class I, a cell surface receptor, on the cell surface. You are trying to determine the mechanism for how the virus is decreasing cell surface MHC I. You decide to do an experiment to determine whether the receptor is making it all of the way through the secretory pathway. You take two samples of cells. 1. Uninfected 2. Infected with SARS-COV2 You treat them with EndoH and analyze MHC I on a western blot and get the following results: 1. Uninfected cells - 50% of protein is endo H sensitive and 50% is Endo H resistant 2. SARS-COV2 infected cells - 100% of protein is Endo H sensitive How would you best interpret these results? Is MHC I going all the way through the secretory pathway in infected cells? O A. No, MHC I is not going all the way through the secretory pathway. 100% of the protein is EndoH sensitive in infected cells, this means that the virus is somehow inhibiting the protein from making it through the Golgi. O B. No, MHC I is not going all the way through the secretory pathway. Only 50% of the protein is EndoH resistant in infected cells, this means that the virus is somehow inhibiting half of the protein from making it through the Golgi. O. Yes, MHC l is going all the way through the secretory pathway. 100% of the protein is EndoH sensitive in infected cells. This means that the virus has no effect on the protein from making it through the Golgi. O D. No, MHC I is not going all the way through the secretory pathway. Only 50% of the protein is EndoH resistant in uninfected cells, this means that the virus is somehow inhibiting half of the protein from making it through the Golgi.

Essentials of Pharmacology for Health Professions
Essentials of Pharmacology for Health Professions
7th Edition
ISBN:9781305441620
Author:WOODROW
Publisher:WOODROW
Chapter14: Antineoplastic Drugs
Section: Chapter Questions
Problem 4CRQ
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You are studying SARS-COV2. You identify a viral protein that results in the decrease of MHC class I, a cell surface receptor, on the cell surface. You are trying to determine the mechanism for how the virus is decreasing cell surface MHC I. You decide to do an experiment to determine whether the receptor is making it all of the way through the secretory pathway. You take two samples of cells. 1. Uninfected 2. Infected with SARS-CoV2 You treat them with EndoH and analyze MHC I on a western blot and get the following results: 1. Uninfected cells - 50% of protein is endo H sensitive and 50% is Endo H resistant 2. SARS-COV2 infected cells - 100% of protein is Endo H sensitive How would you best interpret these results? Is MHC I going all the way through the secretory pathway in infected cells? A. No, MHC I is not going all the way through the secretory pathway. 100% of the protein is EndoH sensitive in infected cells, this means that the virus is somehow inhibiting the protein from making it through the Golgi. B. No, MHC I is not going all the way through the secretory pathway. Only 50% of the protein is EndoH resistant in infected cells, this means that the virus is somehow inhibiting half of the protein from making it through the Golgi. C. Yes, MHC I is going all the way through the secretory pathway. 100% of the protein is EndoH sensitive in infected cells. This means that the virus has no effect on the protein from making it through the Golgi. D. No, MHC I is not going all the way through the secretory pathway. Only 50% of the protein is EndoH resistant in uninfected cells, this means that the virus is somehow inhibiting half of the protein from making it through the Golgi.
Transcribed Image Text:You are studying SARS-COV2. You identify a viral protein that results in the decrease of MHC class I, a cell surface receptor, on the cell surface. You are trying to determine the mechanism for how the virus is decreasing cell surface MHC I. You decide to do an experiment to determine whether the receptor is making it all of the way through the secretory pathway. You take two samples of cells. 1. Uninfected 2. Infected with SARS-CoV2 You treat them with EndoH and analyze MHC I on a western blot and get the following results: 1. Uninfected cells - 50% of protein is endo H sensitive and 50% is Endo H resistant 2. SARS-COV2 infected cells - 100% of protein is Endo H sensitive How would you best interpret these results? Is MHC I going all the way through the secretory pathway in infected cells? A. No, MHC I is not going all the way through the secretory pathway. 100% of the protein is EndoH sensitive in infected cells, this means that the virus is somehow inhibiting the protein from making it through the Golgi. B. No, MHC I is not going all the way through the secretory pathway. Only 50% of the protein is EndoH resistant in infected cells, this means that the virus is somehow inhibiting half of the protein from making it through the Golgi. C. Yes, MHC I is going all the way through the secretory pathway. 100% of the protein is EndoH sensitive in infected cells. This means that the virus has no effect on the protein from making it through the Golgi. D. No, MHC I is not going all the way through the secretory pathway. Only 50% of the protein is EndoH resistant in uninfected cells, this means that the virus is somehow inhibiting half of the protein from making it through the Golgi.
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