The experiment shown in thefigure below uses two strains of mice that differ in their MHC genes. Strain A is H-2a and Strain B is H-2b. Mice of each strain are infected with the virus LCMV, and T cells are isolated at day 8 post-infection. These T cells are mixed with target cells that express either H-2a or H-2b; in each case, the target cells are either uninfected or infected with LCMV. After a four-hour incubation of T cells with target cells, the percentage of target cells lysed by the T cells is shown in the graph. The explanation for the results of this experiment is:Mice of strain B do not make a T cell response to LCMV.Mice of strain A make a more robust T cell response to LCMV than mice of strain B.Target cells that express H-2b cannot be infected with LCMV.T cells from mice of strain A only recognize viral peptides on target cells expressing H-2a. LCMV peptides do not bind to MHC class I molecules from H-2b mice. Mouse AMouse Blymphocyticchoriomenigitisvirus (LCM)MHC-H-2aMHC-H-2bI cellsI cellsTarget cells: H-2aTarget cells: H-2b100-75–8 50-25-0.I cells fromI cells frommouse Bmouse ALCMV-infected H-2ª target cellsuninfected H-2ª target cellsLCMV-infected H-2° target cellsuninfected H-2° target cellstotal cell killing (%)

An efficient adaptive immune system requires the TCR's capacity to distinguish aliens from…

Answered: The experiment shown in thefigure below…

Biology: The Unity and Diversity of Life (MindTap Course List)

15th Edition

ISBN:9781337408332

Author:Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr

Publisher:Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr

Chapter37: Immunity

Section: Chapter Questions

Problem 5SQ: Which is/are not part of adaptive immunity? a. phagocytic cells b. antigen-presenting cells c. MHC...

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The experiment shown in thefigure below uses two strains of mice that differ in their MHC genes. Strain A is H-2^aand Strain B is H-2^b. Mice of each strain are infected with the virus LCMV, and T cells are isolated at day 8 post-infection. These T cells are mixed with target cells that express either H-2^aor H-2^b; in each case, the target cells are either uninfected or infected with LCMV. After a four-hour incubation of T cells with target cells, the percentage of target cells lysed by the T cells is shown in the graph. The explanation for the results of this experiment is:

Mice of strain B do not make a T cell response to LCMV.
Mice of strain A make a more robust T cell response to LCMV than mice of strain B.
Target cells that express H-2^b cannot be infected with LCMV.
T cells from mice of strain A only recognize viral peptides on target cells expressing H-2^a.
LCMV peptides do not bind to MHC class I molecules from H-2^b mice.

Mouse A
Mouse B
lymphocytic
choriomenigitis
virus (LCM)
MHC-H-2a
MHC-H-2b
I cells
I cells
Target cells: H-2a
Target cells: H-2b
100-
75–
8 50-
25-
0.
I cells from
I cells from
mouse B
mouse A
LCMV-infected H-2ª target cells
uninfected H-2ª target cells
LCMV-infected H-2° target cells
uninfected H-2° target cells
total cell killing (%)

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