Amyloid

Alheimer’s disease is a progressive disease that worsens as time go by. This disease affects the short term memory and is not part of normal aging. Currently, this disease has no cure. As Alzheimer;s disease get more progressive, it can affect how a person lives and those people will need help going on about their lives. Alzheimer’s disease can be caused by a combination of how a person lives, from their genetics, and the environment that person is in. People who are affected with disease

Although Alzheimer’s disease (henceforth: AD) has been around since the 19th century or possibly even earlier and was at a point in time classified as senile dementia, it wasn’t until 1906 following Dr. Alois Alzheimer’s encounter with Auguste Deter at a Frankfurt asylum that the name of the disease was finally coined. Since then, major developments relating to the disease has taken place. In our report, we addressed some of the areas of the history, contemporary and prospects of the disease. Some

patients. MRI scans are able to measure the size of various structures in the brain, while PET scans are used in conjunction with radioactive tracers to measure functional changes in brain energy metabolism as well as to measure the amount of beta-amyloid, a misfolded protein which is characteristic of Alzheimer’s pathology. [7] [8]

Atherosclerosis, inflammation and cardiovascular disease In most countries, Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of morbidity and mortality. Despite advances in the treatment of acute and/or chronic coronary syndrome, additional therapies are still needed to reduce the high rates of recurrent CV events. Since 19th centaury it was suspected that the pathogenesis of atherosclerosis involves process of inflammation, which has become recognized as a contributory factor

Cloning Process Buccal swabs or whole blood samples (2-5ml) will be taken from a patient with Alzheimer’s disease. This will be transported to the lab immediately for RNA extraction. The ChargeSwitch gDNA/RNA technologies Purification Kits protocol will be used for the DNA extraction. A reverse transcription PCR (RT-PCR) procedure will be carried out using the designed primers for cDNA. The cDNA is obtained from the mRNA and not the genomic DNA. Derived cDNA will not be manipulated to obtain sticky

 The cell recognizes the decreased amount of normal  protein and creates more of it, but it is converted to misfolded protein. This  happens over and over. Then all the abnormal protein comes together  to form  a sticky accumulation of plaque called amyloid plaque.

Alzheimer’s disease is one of many forms of Neurocognitive disorders that ultimately leads to the loss of memory. There are 5 stages of Alzheimer’s disease; each stage gets progressively worse resulting in difficulty recalling memories and faces, periods of confusion, loss of the ability to communicate effectively, and inevitably death. The severity of loss can range from minor forgetfulness to more serious conditions where a person affected by Alzheimer’s may forget the faces of close family members

Alzheimer’s disease slowly steals a person’s dignity and erases precious memories. The “Alzheimer’s Disease Guide”, found on WebMD explains that tasks become more difficult to do often leading to confusion and behavior changes. The article further explains the progression of the disease also brings hardship to family and friends (1). To best cope with Alzheimer’s we must better understand the disease. Alzheimer’s disease can often be seen during autopsies of the brain. In her book,

the hippocampus and the neocortex region of the brain. These are affected by the deposition of amyloid β in senile plaques, neurofibrilary tangles and the decline of neuronal synapses. The symptoms of AD includes memory loss resulting in disrupted daily life, confusion with place and time, problem with speaking and writing and many other. Earlier research was done on the inhibition of amyloid β, but a relatively new approach is to find inhibitors for acetlycholinesterases enzyme (AChE).

early-onset Alzheimer’s disease. It is caused by gene mutations that can be passed from parent to child. The most common form of late-onset Alzheimer’s disease is caused by the inability to clear amyloid-beta protein from the brain. Cerebrospinal is what help clear out the bad things in the brain, like amyloid-beta. Alzheimer’s is a disease which causes the brain to lose its tissue over time. Doctors thought that was a normal thing that happened as people get older. They didn’t think that it could be