(chemical hormones made up of unsaturated fatty acid molecules) which are needed for platelet aggregation, and anti-inflammatory purposes (9). Aspirin is a non-selective inhibitor meaning it inhibits both Cyclooxygenase enzymes. It does this because of a complex, chemical process called Acetylation where an acetyl group forms a covalent bond with a serine group found in the active site of the COX enzyme. COX-2 enzymes are used to convert and develop arachidonic acid into prostaglandin H2 which in turn produces
Aldrich chem. Co. England. Fresh human serum (obtained from Medical Research Institute Blood Bank) was used as source of the enzymes. The enzymes SALT and SAST activities were assayed by the method of Reitman and Frankel.(13) In this method; the keto acid formed were measured colourimetricaly after combination with 2,4-dinitrophenyl hydrazine, then the hydrazone formed was measured at 530
is a neutral molecule. Alcohol groups are mildly acidic and could theoretically act as an acid at a high pH, but that would happen very rarely, certainly not at physiological pH. There are no basic groups in Prednisolone. 6. Ionisation state of the drug in the stomach (pH of 2) and blood (pH of 7.4) Prednisolone would remain in this neutral state both at pH 2 and at pH 7.4. This is because its strongest acid pKa is 12.59 (the tertiary alcohol; the primary and the secondary alcohols have pKa values
In 1990, Morrow, Roberts, and colleagues reported the formation of prostaglandin (PG)-like compounds in vivo, termed isoprostanes, by free radical-induced peroxidation of arachidonic acid (Morrow, Harris et al. 1990). Analogous to the cyclooxygenase enzymatic pathway, intermediates in the IsoP pathway are PGH2-like bicyclic endoperoxides. In aqueous media, PGH2 is unstable and undergoes rearrangement to form -ketoaldehydes, levulinaldehyde derivatives termed levuglandin E2 and D2 (Salomon, Miller
Vitamin A, arachidonic acid, taurine, and arginine cannot be synthesized by cats and must be obtained from the diet. Arachidonic acid is a fatty acid, without it, felines may experience reproductive failure and difficulty clotting blood, making it difficult to heal wounds(Zaghini & Biagi, 2005). Taurine is an amino acid found as a free compound in animal tissues. A taurine deficiency in cats can lead to blindness as the retina degenerates (Zaghini & Biagi, 2005). Arginine is also an amino acid, and plays
diet is rich in unsaturated fatty acids that cannot be digested easily. As a result they cause ulcers and wounds in digestive tract leading to inflammatory bowel disease (Reif et al., 1997; Ananthakrishnan et al., 2013; Paik, Fierce, Treuting, Brabb & Maggio-Price, 2013). Polyunsaturated fatty acid (PUFA) present in high fat feed contain linoleic acid. Linoleic acid belongs to polyunsaturated fatty acid that is metabolized to arachidonic acid. Arachidonic acid
Module 01 Homework Assignment Use the information presented in this module along with additional outside research to answer the questions: 1. Describe how applied microbiology is used to improve aspects of life and the environment. Microbiology is the study of microorganisms (VanMeter, VanMeter, & Hubert, n.d., p.3). These are all of the things not visible to the human eye. With the study of microbiology, it enables us to find things such as viruses and bacteria. This is helpful because
1. Soccer is one of the most demanding of all sports. The game is played on one of the largest fields of any sport, for the longest sustained time and with the least amount of breaks. Players in a soccer team are in continuous activity as they compete for loose balls, move to encourage teammates, rotate positions and run to make a space or test opponents. Running, jumping, sprinting movements in relation with sudden changes of acceleration and route outweigh the play. The power of the game ranges
group of protein and protein can break easily by acid, base, and hot temperature. To experiment our question, we used catalase solution, 3% H2O2 solution, 0.1 M HCl solution, 0.1 M NaOH solution, a beaker, an O2 gas sensor, sensor interface on a Chromebook, pH paper, and safety gloves. Therefore, we conducted experiments to test how enzyme activity in different conditions. Plus, we predicted that if temperature increases or enzyme have contacts with acid or base, enzyme activity will decrease. We
Meat Tenderness, and Consumer Perceptions Introduction The current climate of the relationship between the food-producing industry and consumers is volatile. Current self-appointed consumer leaders such as Vani Hari, known as the “Food Babe” (foodbabe.com) pressure food industry sectors for changes in products. Reasoning for these changes largely reside in the practices of fear-mongering, using terminology outside the knowledge of the readers these leaders attract, exacerbating worst-case scenarios