Haemophilia A

Hemophilia A and B are x-linked disorders that cause bleeding due to the absence of a coagulation factor, which arise from mutations in the VIII (FVIII) and IX (FIX) factor genes1. Recent advances in the field of gene therapy have unveiled the use of adeno-associated vectors (AAV) and adenovirus vectors (Ad) to increase the levels of expression of the VIII and IX factors, counteracting the effects of the mutation 1. Gene transfer methods of the coagulation factor IX using AAV has resulted in dogs

Hemophilia is a hereditary and genetic mutation blood disease that does not have the ability to form a blood clot or coagulate from a small injury. The word hemophilia comes from two Greek words: haima - meaning blood and philia meaning to love. In order for the blood to clot properly, the plasma proteins also called factors need to be present in the blood. When the body forms antibodies to the clotting factors in the blood, it will stop the clotting factors from working. There are 13 types of

He cut his small toe when he was one year old. There was unusual bleeding. He was given a blood transfusion at a local hospital. He started bleeding frequently from different sites such as, his gums, nose and ears. At the age of four, he bled from his forehead and hip after a fall. He was tested at Christian Medical College Hospital, Vellore and he was diagnosed as having Type ‘A’ Hemophilia with severity at less than 1 %. He had a major bleed in his urinary tract for which he was treated at St John’s

Hemophilia Epidemiology Student Name Institutional Affiliation Date   Abstract This paper on the epidemiology of hemophilia is very comprehensive. It involves substantial research on the topic from various books and websites of highly recognized organizations such as World Health Organization and Center for Disease Control and Prevention. The purpose of this paper is to determine the causes, effects and prevalence of hemophilia in the world. The paper will also cover on severity and management of

Sarah Griffin BIO 271-IN1 Disease/Disorder Paper 4/16/15 Hemophilia A Hemophilia is a rare blood condition in which an individual’s blood cannot clot appropriately to stop bleeding. There are two types of Hemophilia, Hemophilia A and Hemophilia B. This paper will be focusing on Hemophilia A, also known as classic hemophilia. “Hemophilia A is a genetic disorder caused by a missing or defective factor VIII, a clotting protein” (National Hemophilia Foundation, n.d., para. 1). Clotting proteins work

Hemophilia Hey do you know what hemophilia is? Well it's a bleeding disorder, when you bleed too much when having an injury making you have too much blood loss. There are treatments that can help you if you have Hemophilia ,but sadly we have no cure for it yet. When you have Hemophilia you have to stay away from things that can hurt you like when you are reading a book you have to be careful because you don't want a paper cut.The treatments that can help you when you

There are four main types of Epidermolysis Bullosa, all can be fatal and they affect infants and children. Each case is different but all of them are extremely painful. Each one ranges from a form of a mild case to severe case and sometimes even death. The four types of Epidermolysis Bullosa include Dystrophic Epidermolysis Bullosa, Epidermolysis Bullosa Simplex, Junctional Epidermolysis Bullosa and Epidermolysis Bullosa Acquista. Each one mentioned above is very different form the other. Each one

A large number of mutations for Hemophilia A have been detected and identified. The most common mutation found is the intron twenty-two inversion and intron one inversion of the Factor VIII gene. This mutation occurs in 40-50 percent of people with Hemophilia A. It is caused by the homologous recombination between copies of a DNA sequence. One copy is located on the intron 22 region of factor VIII and the other copies are distal to the factor VIII. Intron one of the factor VIII gene occurs when the

Hemophilia has 2 types: Hemophilia A, and Hemophilia B. Hemophilia A is also known as “Factor VIII Deficiency” and Hemophilia B is also known as “Factor IX Deficiency”. Hemophilia A is more common than Hemophilia B. Hemophilia A means that the body does not have enough clotting for Factor VIII. Hemophilia B is less common than Hemophilia A. Hemophilia B means that the body does not have enough clotting for Factor IX. Neither is better than the other. They both make you bleed longer than you should;

Hemophilia, once called the royal disease is a problem with the clotting of blood. When a cut or bruise occurs it can bleed causing problems with people who suffer from hemophilia. Patients with hemophilia will continually bleed longer than a normal individual. This bleeding can lead to harmful levels of blood loss to internal bleeding. Hemophilia is very rare occurring once every five thousand people. Rare, however it is the most common x linked trait. When an injury occurs, blood cells called