Peroxisome proliferator-activated receptor

Orlistat (also known as tetrahydrolipstatin) is a drug designed to treat obesity. It is marketed as a prescription under the trade name Xenical by Roche in most countries, and is sold over-the-counter as Alli by GlaxoSmithKline in the United Kingdom and the United States. Its primary function is preventing the absorption of fats from the human diet by acting as a lipase inhibitor, thereby reducing caloric intake. It is intended for use in conjunction with a healthcare provider-supervised reduced-calorie

| Peroxisome in animal cell | Life sciences, HAN university of applied science, Nijmegen, Netherlands | | Mohsen Ghanbari | 30-12-2012 | Peroxisome in animal cell Author: Mohsen Ghanbari Abstract Peroxisomes have an essential function in cell metabolism. [1] They are small, membrane bounded organelles that have at least fifty different enzymes for several metabolic reactions. [2] Their appearance is like lysosomes; however, their main function is oxidation reactions especially oxidation

Egypt d Molecular Genetics Department, National Research Centre, Cairo, Egypt Abstract Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. The Pro12Ala polymorphism in the Peroxisome Proliferator-Activated Receptor-gamma 2 (PPARγ2) gene accounts for metabolic dysfunction in women with polycystic ovary syndrome (PCOS) remain obscure. The aim of the present study was to establish a possible association between PPARγ2 gene pro12ala polymorphism

gestational age and cause preterm delivery is through activation of peroxisome proliferator activated receptor (2014). Huang et al.(2014) stated that “ peroxisome proliferator activated receptor is a ligand activated transcription factors that can be activated by phthalates” (p. 7). As such, “the activation of peroxisome proliferator activated receptor may increase the secretion of prostaglandins and matrix metalloproteinase, which can promote uterine contraction and rupture of the membranes” (Huang

A comprehensive search in PubMed, Science Direct and Google Scholar was conducted to identify published studies related to PPARG gene and diabetic nephropathy. The keywords such as ‘Diabetic nephropathy’, ‘peroxisome proliferator activated receptor gamma’, ‘PPARG’, ‘Pro12Ala polymorphism’ and rs1801282 were used in various combinations. The search was done without any restrictions to identify all relevant papers and the last quest was updated on 25th July 2017. After initial screening full text of

increases glucose utilization in the periphery, and increases insulin sensitivity. Metformin is contraindicated in patients with renal impairments or vascular disease. Thiazolidinediones a medication which increases receptor molecules, specifically peroxisome proliferator-activated receptors. These molecules help the transcription of genes for fat and glucose metabolism. Adverse effects include increased edema and congestive heart failure. Dipeptidyl peptidase-4 inhibitors is a medication which reduces

Pathogenesis of the PPAPs receptors in heart failure. Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors (1), participate in lipid and glucose metabolism (2,3) respond to a wide variety endogenous and exogenous ligands (4). There is three subtypes, PPAR훼, PPAR훽/훿, and PPAR훾 , are known (2). PPAR훼 is expressed in heart, intestine, skeletal muscle, adipose tissue and kidney. PPAR훽/훿 is presented in all tissue. PPAR훾 is mainly presented large intestine, heart and adipose

Increased ApoB and decreased LDL receptor cause Mixed Hyperlipidemia. 2. Increased VLDL synthesis by the liver is caused by the production of excessive free fatty acid by various tissues. FCH is found commonly in patients suffering from the other metabolic syndrome diseases("syndrome

of “glitazone” or thiazolidinediones is an important event (14). Thiazolidinediones are being developed for the treatment of type 2 diabetes mellitus and insulin resistance. Thiazolidinediones binds and activate the peroxisome proliferator-activated receptor γ (PPAR), a nuclear receptor that regulates the several genes which are involved in metabolism. The PPAR γ controls lipid storage, insulin sensitization and adipocyte differentiation. Besides the metabolic activities, thiazolidinediones also have

Nuclear hormone receptors (NHRs) are the second largest receptor target class, targeted by 116 different drugs and the third largest family of individual drug targets, at a total of 13% of drug targets in the human genome (Figure 4.2). NHRs can divided into the following subfamilies: steroid receptor family, thyroid/retinoid receptor family, and orphan receptor family. The steroid receptor family is the most clinically targeted subfamily amongst the NHRs, encompassing for almost 80% of all NHR-targeting