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Kalydeco (ivacaftor or VX-770) is a quinolone carboxyamide small molecule drug used to treat cystic fibrosis in patients with a specific genotype (Deeks 2013). Cystic fibrosis is a genetic disorder that can affect various organs of the body and eventually leads to pulmonary disease. The genetic basis of this disease is that of mutations within the cystic fibrosis transmembrane conductance regulator (CFTR), which codes for a glycoprotein found on the apical surface of epithelial cells (Deeks 2013)

Chemical, biological, and nuclear weapons have changed the way that people look at wars forever. Since their implementation into the battlefield, it has been realized that these taboo weapons are ones to be feared. Responsible for an extravagant amount of deaths over the past eighty years, chemical, biological, and nuclear threats are not to take lightly. A nuclear weapon is an “explosive device designed to derive its destructive explosion via nuclear fission, nuclear fusion, or a combination of

Fore! A Newtonian and Projectile Motion Study of the Golf Swing Physics Around Campus Tim Stoddard Physics 102 Spring 2015 Figure 1 below depicts a snap shot of the compact and physics-ridden entity known as a golf swing. Taken at my home in Olympia, WA, this picture was taken moments before the impact between my driver and the Titleist Pro V1 golf ball. The game of golf is riddled with physics concepts governing everything from the power generated in the swing, to every

In Borderlands/La Frontera, Mexican Feminist theorist Gloria Anzladua’s introduces an analytical framework for considering the relationship between minority faces, spaces, and languages as they compete, interact and inform America’s institutionalized whiteness. While her book specifically deals with the “minority faces” of Mexican immigrants, the epigraph suggests, racial minorities who interact with historically white spaces cross a “border” that is at once culturally and linguistically metaphoric

Ethical Implications of Chemical, Biological and Nuclear Warfare Thesis As current problems of terrorism and the war on Iraq, chemical, biological and nuclear warfare (CBW) issues are important and relevant. CBW agents are dangerous, uncontrollable and undifferentiating weapons of mass destructions. Chemical, biological and nuclear weapons are capable of mass destruction aimed at killing masses of people. Using CBW agents comes with many ethical dilemmas and consequential side-effects

Figures Unreadable The National Market for Cellular Phone Service The national cellular market is undoubtedly one of the nation’s most expansive markets. In 2003, wireless revenues totaled to over $100 Billion; nearly one percent of the United States GDP. Since wireless has emerged, the typical buyer has expanded from the average middle/upper-class adult to teenagers, elderly, and business consumers. 20% of American teenagers own cell phones, explaining why Virgin Mobile was founded to

A PROJECT REPORT ON “FINGERPRINT RECOGNITION AND IMAGE ENHANCEMENT USING MATLAB” Submitted in partial fulfillment Of the requirements for the award of the degree in BACHELOR OF TECHNOLOGY IN APPLIED ELECTRONICS AND INSTRUMENTATION ENGINEERING SUBMITTED BY: SHAKTI ABHISHEK- 0803112 SATISH GOYAL - 0803064 ROHIT DASH - 0803086 MD. IRFAN ARIF RAHMAN - 0803117 [pic] DEPARTMENT OF APPLIED ELECTRONICS AND INSTRUMENTATION ENGINEERING GANDHI INSTITUTE OF ENGINEERING AND TECHNOLOGY Biju Patnaik University

The eye of a hurricane passes over New Orleans in a direction 60.0° north of west with a speed of 41.0 km/hr. Three hours later, the hurricane suddenly shifts due north, and its speed slows to 25.0 km/hr. How far from New Orleans is the hurricane 4.50 hours after it passes over the city? v1 = 41.0km/hr(cos30°, sin30°) = (35.5, 20.5) km/hr v2 = (0, 25.0)km/hr → D = v1×3hrs + v2 × 1.5hrs =Answer (105.9, 99) km A ship which can move at the velocity of v0 = (12, 6) m/s (x-axis: the West to the

Pain is necessary and important. In fact, it is an inborn drive, vital to our very existence (Hebb). Pain prompts us to change something, for instance, to move our hand off of a hot stove. It, therefore, prevents us from causing damage or even death to ourselves. It motivates us to protect an injured area, and the abatement of that pain lets us know when it is safe to use that area of our body again (Doctor's Surgery Center). While pain is a crucial sensation, required for our survival, it’s no secret

Chapter 7 Notes Page 1 Variable Costing Absorption As we have seen in previous chapters, when you manufacture your own inventory, the cost of that inventory includes all of the costs associated with running the factory that produces the inventory. Generally, no part of the factory cost is expensed. Instead, it is capitalized as the cost of the inventory produced. It is only expensed when the inventory is sold. At that point the cost of the inventory becomes Cost of Goods Sold. This system is