write a mechanism for the Friedel-Crafts reaction of anisole with acetic anhydride to produce what you believe is the major isomer of methoxyacetophenone. Be sure to show all structures of reactants, products and intermediates as well as the movement of electrons in each step.
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write a mechanism for the Friedel-Crafts reaction of anisole with acetic anhydride to produce what you believe is the major isomer of methoxyacetophenone. Be sure to show all structures of reactants, products and intermediates as well as the movement of electrons in each step.
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- Explain why attempts to use esters for Friedel-Crafts acylation always lead to a complex mixture of alkylated and acylated products.How do you account for the fact that the dipole moment of acetonitrile is considerably greater than that of either fluoromethane or chloromethane?To synthesize m-ethylbenzenesulfonic acid, a student attempted the Friedel–Crafts alkylation of benzenesulfonic acid with bromoethane. Do you predict that this reaction was successful? If not, propose an alternative synthesis.
- Provide a mechanistic explanation for the following observation.Write the overall balanced equation and mechanism for the transformation of bromobenzene into benzoic acid through a Grignard reaction. Include all reagents and products but not solvents.We used biphenyl instead of benzene for Friedel-Crafts alkylation. What would you predict the major product would be if we had used benzene instead? Why?
- A student was given from the list of the compounds below A, B and D blindly and asked to identify them all. He treated each of them with Brady's reagent (2,4-ditrophenylhydrazine) and isolated a bright yellow compound for one of them, but the other two gave false negatives. The student reasoned that the false negatives may be due to sterics and, on further thinking, it dawned on him that he might be able to rule out one of the false negatives with the haloform test. What compound did he find compatible with the haloform test? That compound did indeed give a false negative in the Brady test. Which of the other two was positive in the Brady test? A = haloform B = Brady A = haloform D = Brady B = haloform A = Brady B = haloform D = Brady D = haloform A = Brady D = haloform B = BradyExplain the Summary of Alkyl Halides and SN1, SN2, E1, and E2 Mechanisms ?[Grignard Synthesis of Benzoic Acid] Characterization 1. Explain melting point determination as a characterization technique 2. Explain IR spectroscopy as a characterisation technique.
- Write the mechanism for the Friedel Crafts Acylation reaction of ethylbenzene using acetyl chloride and aluminum chloride. What ratio of ortho-, para-, and meta- products would you expect? Explain why you expect that ratio.The Friedel-Crafts acylation reaction of compound Q and 2-(1-phenylethyl)-1,3-dioxolane was also found to give a second unknown compound, which 1 H NMR spectroscopy suggested was a regioisomer of intermediate R. Suggest a structure for this second unknown compound.1. If diene is used in excess for a Diels-alder reaction of a-phellandrene and malice acid, which side reaction would be expected? Use chemical equations to support your answer. 2. If methanol was used instead of diethyl ether as the reaction solvent and left tp reflux longer than necessary, what side reactions would you expect to happen. in the reaction flask. Use a chemical equation to support your answer.