1. Describe the “phenotype” that is being studied in this analysis and the specific prior evidence that suggests that any further work will reveal a genetic factor. Restless legs syndrome is a condition characterized by four general criteria. i. Impulsiveness to move limbs regardless or paresthesia ii. Subjects experience worsening symptoms at rest iii. Partial relief of symptoms associated with movement iv. Symptoms tend to worsen in the evening Although the exact cause is unknown, this study illustrates a positive correlation derived from pathology studies of reduced intracellular iron stores and familial history upwards of 65% denoting possible inheritance of genetic attributes. Previous studies show that RLS symptoms may improve with dopaminergic medication suggesting a possible mechanism pertaining to the dopaminergic system. 2. Why did this study examine ONLY people from “North America” in conducting this specific linkage analysis? Why not other populations? Baylor College of Medicine ran this study to examine multiplex RLS presence in 15 separate families. Since the goal is to examine heritable factors, this study required willing and related participants, which happened to be 453 subjects accessioned at the Movement Disorders Clinic by Baylor in Texas. Furthermore, the introduction claims that the RLS phenomena is more prevalent in populations of European ancestry compared to Asians and Africans. Thus, these studies are specifically for families with a history of
(Coffey et al., 2003; Cox et al., 2001; Finn et al., 2000). These findings are correlational,
Furthermore, people born with this unique genetic defect share some similar characteristic traits and features that are both physical
The purpose of this paper is to discuss the effects of the disorder and how genetics and biochemistry work together to create this
hereditary disorder of Caucasians in the United States and is the most common cause of chronic
The Restless Leg Foundation has a tremendous amount of resources to help people gain a deeper unRLSHOMELOGOderstanding of what RLS is, why people get it, and how to live with it. Their work towards awareness and advocacy is my inspiration for this post. As educators I believe it is important to always be learning. This site can provide you with far more resources as well as answer specific questions about RLS.
families, and that genes likely play a role in the development of the disorder. [...] (IOCDF.)”
Conferring to the case study 1 of Ms. A, who is suffering from iron deficiency anemia. “People who experience iron deficiency anemia lack adequate iron required to produce hemoglobin. Hemoglobin supports red blood cells in carrying oxygen all through the body” (Mayo Clinic, 2014). In this presentation, the writer will provide rationales where Ms. A is presenting signs and symptoms of Iron Deficiency Anemia.
However, Hakin, Cherkas, Spector and MacGregor (2003) research indicated there is no known genetic predisposition.
| Based on explicit knowledge and this can be easy and fast to capture and analyse.Results can be generalised to larger populationsCan be repeated – therefore good test re-test reliability and validityStatistical analyses and interpretation are
The tests for normality, examining standardized skewness and the Shapiro-Wilks test indicated the data were statistically normal for origination rates. However, the Levene's F test revealed a violation of the homogeneity of variance assumption by race was not met for female originations (p = .025). As such, the Welch's F test and the posthoc James-Howell procedures were used. The results presented in Table 4 capture the one-way ANOVA for the race effect on origination rate. For females, the one-way ANOVA revealed a statistically significant main race effect on origination rates, Welch’s F(4, 9.87) = 30.07, p < .001, ω2 = .83. Omega squared has shown approximately 83% of the total variation in females’ origination
approximately a one in eight chance of developing this dreaded disorder (Berger, 407). Being a
Restless leg syndrome, or also known as RLS and Willis-Ekbom Disease, is a neurological condition in which one experiences unpleasant sensations in the legs. The term RLS was introduced by a doctor named Karl-Axel Ekbom. Ekbom had a large number of patients complaining of “peculiar and tormenting paraesthesias deep in the lower legs” which led him to find out more. In 1944 he had already reported 8 patients with the same type of symptoms and by 1945 he had published a doctoral thesis called “Restless legs’: ‘a clinical study of a hitherto overlooked disease in the legs characterized by peculiar paraesthesia (‘Anxietas tibiarum’), pain and weakness and occurring in two main forms, asthenia crurum paresthetica and asthenia crurum dolorosa”
Third, restless leg syndrome (RLS) also is a common sleep disorder. RLS is a neurological disorder that makes someone want to move their legs persistently. In some cases, body parts are persistent as well during sleep. Restless leg syndrome is considered a sleep disorder because whenever the constant need to shake the legs, it can make it hard to maintain sleep and the ability to get to sleep. One of the most common side effects reported that is related to RLS is sleep loss. Sleep lose can lead to diminished quality of life, sleepiness during the day, loss of memory, depression and many other symptoms.
Restless legs syndrome is a common yet frequently undiagnosed sensorimotor disorder. In 1995, the International Restless Legs Syndrome Study Group developed standardized criteria for the diagnosis of restless legs syndrome. Since that time, additional scientific scrutiny and clinical experience have led to a better understanding of the condition. Modification of the criteria is now necessary to better reflect that increased body of knowledge, as well as to clarify slight confusion with the wording of the original
Therefore, the additive genetic effects are represented by the heritability factor (H2R= 0.5899504). Thus, 58.99% of the variation in GSP levels in the Mexican American cohort can be attributed to genetic variation among individuals in that cohort. Furthermore, the phenotypic screen reported that 53.07% of variation seen in GSP levels among individuals of the Mexican-American cohort is due specifically to the phenotypic covariates or traits that were significant and included in the final model (Age, Sex, BMI, SBP, HDLC, HbA1c, Age*DIAB). Thus, this means that the 46.93% of the variance in GSP levels is due to environmental correlation (e).