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Advantages And Disadvantages Of Antiseptics

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Antiseptics are antimicrobial substances applied to skin, mucous membranes or wounds for their bactericidal or bacteriastatic anti-infective effects (McDonnell and Russell, 1999). Chlorhexidine digluconate has been used for more than 50 years and considered as gold standard of antiseptic treatment since this agent is one of the most extensively used and tested (Giannelli et al., 2008). Despite the advantages of chlorhexidine, has disadvantages such as stains on teeth and tongue, desquamation lesions of a mucosa membrane of an oral cavity, breaks irritation, taste changes, tooth staining, moreover will induce a dose dependent reduction in cellular proliferation and that concentrations of chlorhexidine that have little effect on cellular proliferation can significantly reduce both collagen …show more content…

Detoxified conjugates polyhexamethylene guanidine hydrochloride (PHMG-H) and polyhexamethylene guanidine phosphate (PHMG-P) are created by incorporating different anions into its structure and display the property of high solubility in water. In comparison to PHMG-hydrochloride, PHMG-phosphate has a stronger bacteriastatic action with the respect to some strains and has a high threshold of skin irritating, neurotoxic and chronic affects. PHMG-phosphate is odorless, colorless and non-corrosive (Kuznetsov, 2004). PHMG-H was widely tested in “vivo” and in “vitro” (Rosin et al., 2001, Rosin et al., 2002, Welk et al., 2005, Muller and Kramer, 2008). The clinical studies have shown, that PHMG-H mouthwash consistently inhibits plaque regrowth and reduces oral bacterial counts, indicating that PHMG-H could be an alternative active substance of dentifrices. Polyhexamethylene guanidine phosphate (PHMG-P) is created by incorporating anion into its structure and display the property of high solubility in

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