Advantages And Disadvantages Of Parenteral Formulation

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1.3 ADVANTAGES AND DISADVANTAGES OF PARENTRAL FORMULATION [6] 1.3.1 Advantages [7]:- • A direct physiological response is achieved. This is important in medical situation, e.g. cardiac arrest, anaphylactic shock and asthma. • Parenteral formulation is essential for drugs that offer poor bioavailability or those that are rapidly degraded within the gastrointestinal tract. They offer a method to administer drug to patients who are unconscious or uncooperative or for patients with nausea and vomiting. • Local effect may be achieved using parenteral formulation. • Parenteral formulations gladly formulated to offer a wide range of drug release Profile including:  Rapidly acting formulation.  Long acting formulation. Examples of these include intermediate/long-acting insulin formulations and steroid injection. 1.3.2 Disadvantages [8]:- It reverses the effects of drugs that have been administered parentally. This is not harshly the case with other routes of administration, e.g. oral and transdermal. 1.4 FORMULATION CONSIDERATION AND FACTORS AFFECTING PARENTRAL[9] Parenteral formulation categorized as solution, suspension and emulsion. Its main formulation consideration for parenteral formulations is described below. 1.4.1 Solubility of therapeutic agent [10][11] The formulation of…show more content…
More than one third of the drugs listed in the U.S. Pharmacopoeia fall into the poorly water-soluble or water-insoluble categories. It was reported a couple of decades ago that more than 41% of the failures in new drug development is attributed to poor biopharmaceutical properties, including water insolubility. Water insolubility can postpone or totally halt new drug development and can prevent much essential reformula-tion of currently marketed
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