Squamous cell carcinoma (SCC) accounts for 90% of all oral cancers. It may affect any anatomical site in the mouth.(1) Annually,130,000 people succumb to oral cancer in India i.e. approximately 14 deaths per hour. Recently, a trend has been observed towards increasing incidence of OSCC among young adults. (2)The concept of a two-step process of cancer development in the oral mucosa, i.e. a precursor lesion subsequently developing into OSCC, is well established. These precursor lesions are referred as Oral Potentially Malignant Disorders (OPMD). Oral submucous fibrosis (OSF) is one of the commonest OPMD. The malignant transformation rate of OSF ranges from 3 to 19%(2) .OSF is characterized by changes in the connective tissue fibres of the lamina propria and deeper parts leading to stiffness of the oral mucosa and restricted mouth opening (3) and this extensive fibrosis of the connective tissue also causes reduction of vascularity & subsequently hypoxia in oral mucosa (4). OSF has been reported commonly among Indians living in India and among other Asiatics, with a prevalence ranging up to …show more content…
It is clear that additional mechanisms are involved in the malignant transformation of OSF compared with individuals with the same habit but without OSF as the former group shows a much higher incidence of oral cancer. (5)
Hypoxia has been reported to be associated with fibrosis in other organs of the body as it has been shown that renal fibroblasts reduce their turnover and upregulate matrix production when exposed to hypoxia (6). Another study revealed that lung fibroblasts produce augmented levels of TGF-b and enhanced accumulation of collagen during hypoxia (7) . In addition, molecules which are upregulated by hypoxia such as Hypoxia Induced Factor-1α (HIF-1 α) are said to be associated with malignant transformation of epithelia in other
Bacterial infections are causative factors for cancer that have been widely overlooked. Studies in the 90's have shown the bacteria Helicobacter pylori to be a primary cause for gastric cancer. This discovery revolutionized the association between microbial agents and cancers. More recently, studies involving microorganisms in the oral cavity have shown connections to cancerous growth. The inflammation caused by the bacteria P. gingivalis actually leads to changes in cell responses- including those involved in cell death and cell division.
The cancers which cause the upper lip may affect buccal and parotid lymph nodes. Patients with SCC arising in the nasal or paranasal sinuses may complain of nasal fullness, stuffiness, or obstruction, but also of epistaxis, rhinorrhea, pain, paraesthesia, swelling of the nose and cheek or of a palatal bulge. Some may present with a persistent or non-healing nasal sore or ulcer, a nasal mass, or in advanced cases, proptosis, diplopia, or lacrimation. About 95% of the lip cancer which shows very low metastatic tendancy. The cancer which affects the anterior part of the oral cavity called lingual lymph nodes on the floor of the mouth that are located superior to the mylohyoid muscle. The oral cavity and the oropharynx are ideal for early detection due to their good accessibility for inspection. The metastatic pattern of nasopharyngeal cancers was evaluated by the palpation of the neck were resolute the tomographic examination. Based on their findings, we can say that recto pharyngeal lymph nodes are the primary site of metastasis of nasopharyngeal cancers and 94% of the metastasized cancer of the nasopharynx. The cancers in the posterior and the lateral wall metastasize of the oropharyngeal region, firstly into the retropharyngeal lymph nodes and lymph nodes of level II. Many studies show that HPV type 16 plays a vital role in the growth of oropharyngeal cancer and the patients are normally younger. From the hypo pharynx,
Leukoplakia is the most common precursor lesion to squamous cell carcinoma of the oral cavity. There is a male predilection, presumably do to commonly implicated risk factors, smoking and alcohol. It presents as a white plaque with generally well-demarcated borders: early lesions present as homogenously smooth and thin and more advanced lesions may present with nodular, verrucous, or even partially erythematous components. Furthermore, histopathologic examination is characterized by a hyperkeratosis with or without acanthosis. Inconsistent numbers
The neoplasm is assumed to have a nonaggressive nature; however, data regarding the course in HIV immunocompromised persons is scant. A case of orolabial bowenoid papulosis caused by HPV-32is noted.[63]
The incidence of mouth cancer and culture can be related to the diet and sociocultural
Though no exact cause for oral cancers is known, the American Cancer Society says that smoking or use of other tobacco products, heavy drinking and human papillomavirus infections have been shown to increase the risk of developing oral cancer. The use of alcohol and tobacco together increases the risk of oral cancer more than for people who don’t use alcohol or tobacco. Stopping the use of alcohol and tobacco products is the first step in decreasing your chances of developing oral cancer. Seeing your dentist regularly can help to detect any problems while they’re in the early stages.
The first category of the six is carcinoma and it is the most common type. This is cancer that originates in the epithelial tissue or the tissue lining of internal organs. Carcinomas are also known as malignancies of epithelial tissue. These make up approximately 80 to 90 percent off all reported cases of this disease. This could be because epithelial tissue is present all throughout our bodies. Some specific cancers that are considered carcinomas include most lung, breast, prostate, and colon cancers.
The authors of this article, Gypsyamber D’S ouzaOral, Yuri Agrawal, Jane Halpern, Sacared Bodison and Maura Gillison believe that the human papillomavirus (HPV) infection is a reason for oropharyngeal cancer. Furthermore, they all check into it thoroughly to see whether sexual behaviors is the main cause for the high raise of the odds of oropharyngeal cancer advancing in a case control study that is similar to the raising odds of oral HPV infection developing among control patients. The human papillomavirus (HPV) infection was revealed in approximately four point eight percent of three hundred and thirty two control patients that were from an outpatient clinic and in two point nine percent of two hundred and ten men that are of college age
Oral cancer is one of the most common and threatening disease. Thousands have died and are continuing to die today in the United States and around the world. Numerous of people have been diagnosed from oral cancer this year in the United States and other countries like South Asia or in the Northwestern Europe. This typical cancer infused with strength can cause severe pain, discomfort, numbness around and inside the mouth. If the cancer is not treated quickly and properly,the cancer can spread to the body and affect other organs eventually leading to a death road. Oral cancer is sometimes difficult to cure if it's not detected on time in an early stage and it´s important to have precaution and spread awareness for this disease.
Cancer is one of the most destructive and scariest diseases that anyone could develop. According to statistics, there is approximately a 38.5% chance of getting cancer in one’s lifetime. Even if you personally do not get cancer you will live through the destructiveness of cancer from someone close to you because cancer does not discriminate; cancer kills young, old, weak and strong. I myself have lived through this horrible experience and have seen how it completely destroys and tears a family apart. I have lived through all the pain it makes the patient go through. I have seen, however how medical staff bring family together, creates hope for the impossible, and strengthen a patient's will to fight, and that is what I want to undertake.
The National Institute of Dental and Craniofacial Research says that almost 40,000 people in the United States will be diagnosed with oral cancer this year and 7,800 will die as a result of this disease. These are alarming statistics, considering this not only a preventable disease, but one that can be treated successfully when caught early enough.
Alcohol is one of the most dangerous elements related to oral cancer. Studies have proven the relation among poor oral wellbeing and drinking. Though, low oral health is more connected to the abuser’s lifestyle and disregard of their oral wellbeing than the alcohol’s effect on the oral tissue. Moreover, alcoholic drinks such as wine have a low pH value, this acidity results in frequent erosions to the drinker’s teeth. Studies that relate teeth count to alcohol consumption are few, contradictory, and very inconclusive. While some have shown that drinking alcoholic beverages is the reason of having fewer teeth, others have concluded that drinking alcohol decreases the ratio of teeth loss, while others have proven that no correlation
Similarly, studies and research over the last decades have shown the correlation between poor oral health and other pathological ailment. For instance, studies have pointed to the link between oral diseases, specifically periodontal disease and cardiovascular disease (de Oliveira, Watt, & Hamer, 2010; Joshipura et al., 1996). This correlation has been attributed to the raised concentration of C reactive protein and other inflammatory biomarkers caused by systemic inflammatory response resulting from periodontal disease (de Oliveira et al., 2010). Similarly, other studies have shown that visits to dental office increases detection of oral and oropharyngeal squamous cancer (Holmes, Dierks, Homer, & Potter, 2003). Oral and oropharyngeal squamous cell carcinomas are believed to account for 4% of cancers in men and 2% of cancers in women (Holmes et al., 2003). However, poor oral health access means that this prognostic indicator is often detected late, hence decreasing the survival rates of diagnosed patient. Thus oral health care services is necessary for overall health, as its absence creates reduction in systemic health and quality of life (Decker & Lipton, 2015; Naito et al., 2006; Petersen,
In 2014 the annual incidence of head and neck cancer were estimated 5500.000 cases worldwide with a ratio of 2:1 to 4:1 form man to a woman by WHO, HNSCC was recognised the sixth most common cancer by incidence worldwide accounting for approximately 4% of all tumours. It has become clear for the last few decades that HPV infection is etiologically linked to the development of HNSCC, especially those carcinomas that arise in the oropharyngeal region.
Oral cancer is considered to be any cancer that affects the head or neck with the exclusion of the brain. According to The Oral Cancer Foundation, over 43 thousand people will be diagnosed with oral cancer yearly and of that number over 8 thousand of these cases will result in death (Hill, Deitz, & Sax, 2014, p. para 1). Oral cancer consists of squamous cell carcinoma, basal cell carcinoma, Kaposi’s sarcoma, lymphoma, and benign oral cavity tumors. Squamous cell carcinoma is the most common type of oral cancer and is responsible for at least 90% of all oral cancers (Ignatavicius & Workman, 2013, p. 1196). Oral cancer is initially formed by an