Antibiotic Resistance As A Public Health Problem

Throughout my life, adults have insisted the use of antibiotics to fight against the most inconsequential illnesses, whether it’s the cold or the flu. However, neither illness is due to invasion of bacteria. This misuse can lead to antibiotic resistance, also known as antimicrobial resistance(AMR), currently one of the central issues facing the public health system. While the process for antibiotic resistance occurs naturally through the process of adaptation, the mismanagement of antibiotic resources has accelerated the rate at which the bacteria adapt. The occurrence of this misinformation isn’t limited to a few adults: even some of my peers suggest taking antibiotics when faced with the flu. This leads to asking whether AMR is truly a problem and are present regulations enough to combat the issue.

Antibiotics are inarguably one of the greatest advances in medical science of the past century. Although the first natural antibiotic Penicillin was not discovered until 1928 by Scottish biologist Alexander Flemming, evidence exists that certain plant and mold growths were used to treat infections in ancient Egypt, ancient India, and classical Greece (Forrest, 1982). In our modern world with the advent of synthetic chemistry synthetic antibiotics like Erithromycin and its derivative Azithromycin have been developed. Antibiotics have many uses including the treatment of bacterial and protozoan infection, in surgical operations and prophylactically to prevent the development of an infection. Through these applications, antibiotics have saved countless lives across the world and radically altered the field of medicine. Though a wonderful and potentially lifesaving tool, antibiotic use is not without its disadvantages. Mankind has perhaps been too lax in regulation and too liberal in application of antibiotics and growing antibiotic resistance is the price we must now pay. A recent study showed that perhaps 70% of bacterial infections acquired during hospital visits in the United States are resistant to at least one class of antibiotic (Leeb, 2004). Bacteria are not helpless and their genetic capabilities have allowed them to take advantage of society’s overuse of antibiotics, allowing them to develop

The overconsumption of antibiotics is a big contribution to drug resistance and is why users should know what happens with the repeated use of these drugs. Even though some bacterial mutation occurs naturally, human use of antibacterial is the cause of higher-levels of resistance (Alliance for the Prudent Use of Antibiotics 2014). Bacteria mutate either by genetic mutation or by receiving the defensive agent. During an infection bacteria multiply naturally within the body and when exposed to antibiotics, bacteria have an opportunity to adapt to the drug (Alliance for the Prudent Use of Antibiotics 2014). During this period of

(KArch) We as human-hosts are not just helpless victims, our continuous reliance on antibiotics treatment helps contribute to the ever growing problem. The increased and inappropriate use of antibiotic therapy is the main cause of these antibiotic resistant bacteria. Patient this day and age are often prescribed pills for every condition. Patients come into doctors’ offices demanding antibiotics and healthcare providers are filling these orders. This in turn contributed to this growing chain of antimicrobial resistance.

The use of the healthcare system as a whole is largely determined by the cost incurred by the patient, as well as insurance companies within the healthcare system. As for combating the growth of antibiotic resistance, it might be beneficial to increase the cost of antibiotics so that they are used only when clinically appropriate. This, however, would lead to a decrease in access to patients who might actually need these forms of treatment and who are unable to afford them. Additionally, increasing the cost of treatment options may cause there to be a delay or abandonment of therapy. While neither of these options may be ideal to patients, and even the healthcare system as a whole, the consideration of their use may aid in lowering the prevalence of antibiotic resistance.

Antibiotic development is one of the modern marvels of medicine. This is the first external tool that people have to fight against bacterial infections. The first drug developed was Penicillin. This medication is so effective that it is still used today. From its structure, every other antibacterial drug was developed. Today, there are hundreds of options available for treating infections. Unfortunately, this has had significant ramifications on the development of resistance to these medications. As the infections continue to learn and evolve, it is important that people educate themselves on what this means and the impacts it has.

Resistance is easily spread, either ‘horizontally’, through gene exchange within bacteria, or ‘vertically’, through sequential mutation and formation of antibiotic resistance through new generations. (State Government of Victoria 2015) A massive 80-90% of antibiotics ingested are excreted as waste because they are not broken down inside the body. They then enter the environment, allowing gene transfer to occur and facilitating resistance in more bacteria. Therefore, as resistance is spread so easily, the risks become even higher. Additionally, if antibiotics continue to be used so abundantly, the majority will be made resistant due to the widespread use. Moreover, as the current degree of antibiotic use continues, then society’s ability to treat common infectious diseases sharply increase. Those infected with superbugs are unable to respond to standard medicine, thus are ill for a longer period of time, accumulate higher health care costs, and have a greater risk of mortality. According to the World Health Organisation, people with MRSA (methicillin-resistant Staphylococcus aureus), a common infection in hospitals, are 64% more likely to die in comparison with people with the non-resistant form of Staphylococcus aureus. Additionally, as individuals are

The current discovery of growing antibiotic resistant bacteria has been linked to the public’s unaware overuse of antibiotics and changing rates of antibiotic prescription. Many people in the U.S. are already knowledgeable that antibiotics are used to help fight against disease or infections, but the mass population is blind to the negative drawbacks of overusing the antibiotics. The research “ Study shows for antibiotic overuse” by Mike Stobbe (2013) provides a clear explanation of the drawback provided by The Centers for Disease Control and Prevention (CDC) stating that antibiotic resistant bacteria are produced, “when antibiotics are not used long enough or are taken for the wrong reasons, allowing

Antibiotic resistant infections are on the rise in the United States, and this rise can be directly attributed to the over-prescription of antibiotics by healthcare professionals. Even with the many advances in the world today when it comes to antibiotics and treating infections, antibiotic resistant diseases are on the rise. With the diminished ability to destroy the growth of bacteria, the less we are able to get the quick fix that we believe is achieved with the use of antibiotics. Resistance compromises the benefits that we currently have to treat anything from pneumonias to antibiotics given

Antibiotics are commonly used to treat bacterial infections in both humans and animals however the overuse and inappropriate prescription of antibiotics has caused a worldwide concern in antibiotic resistance (FDA, 2015). Antibiotic resistance is when bacteria is able to evolve in such a way enabling the bacteria to survive in the conditions it is in, consequently causing antibiotics being ineffective to the patient (CDC, 2013). Due to this issue implementations and actions have been taken to aid in the reduction of antibiotic resistance.

Antibiotic resistance is a growing problem that must be addressed on a clinical, economical, and research level. According to the antimicrobial resistance AMR, by 2050 “10 million more people would be expected to die every year than would be the case if resistance was kept to today’s level”. Due to over exposure do antibiotics bacterial pathogens have developed both defenses and offenses against antibiotics. These mechanisms provide bacteria to survive antibiotic level that human bodies cannot tolerate. In order to combat this problem two main avenues exist. The first option is big pharmaceutical companies and startup biotechnology companies, backed by venture capitalism, can develop new antibiotics. This process however is not profitable

(3, 4, 6) The United States reports two million people infected with an antimicrobial resistant bacteria and out of two million individuals, 23,000 of those people die each year. (7) Clostridium difficile (C. difficile) is a reported nosocomial, antimicrobial resistant bacteria that infects 250,000 individuals each year. (7, 8) Out of the 250,000 individuals infected with Clostridium difficile (C. difficile), there is a recorded 14,000 deaths. (7, 8) Bacterial resistance is an emerging and ongoing public health threat that causes significantly higher rates of morbidity and mortality compared to antimicrobial-susceptible bacteria. (3, 4, 6) A key factor contributing to the rise in antimicrobial resistant bacteria is the significance of person-to-person or indirect contact, which coherently passes resistant strains of bacteria. (8) The effectiveness and informal access of antibiotics in the 20th century has led to overuse and the emergence of antimicrobial resistant bacteria. (3)

Antibiotic Resistance occurs when bacteria reformat themselves in order to become unaffected by the drugs or substances created to terminate them. They gain resistance to the drugs which causes the drugs to be ineffective of use and leading to more harm. Antibiotic Resistance commonly occurs within patients due to physicians misusing or overusing antibiotics. This creates a common resistance to patients and resulting in the constant creation for new antibiotics that would treat the bacteria. The main conflict generally evolves from medical stewardship where physicians have the responsibility to optimally heal their patients to their best efforts. However this is being neglected by misuse of antibiotics due to several reasons, including patients’ ignorance and fear of malpractice. The authors in the articles “Just give me the script: the scourge of antibiotic misuse and the threat to us all” written by Ranjana Srivastava, “Health-ignorant patients one of many problems exacerbating antibiotic resistance” written by C.L. Doherty, and “Ignorance about antibiotics propelling global ‘superbug’ crisis” written by Helen Branswell, all emphasizes on the topic by developing Ethos, Logos and Pathos towards Antibiotic Resistance.

The overuse of antibiotics has been a problem for well over a decade. This misuse leads to many nonvisible problems arising within the human population. As the use of antibiotics increases, the number of antibiotic resistant bacteria also increases. When bacteria become resistant to an antibiotic, another antibiotic must be used to try and kill it and the cycle becomes vicious. Michael Martin, Sapna Thottathil, and Thomas Newman stated that antimicrobial resistance is, “an increasingly serious threat to global public health that requires action across all government sectors and society” (2409).

According the World Health Organization (WHO), antibiotic resistance is one of the world’s greatest health threats to date (Haddox, 2013). In the article, The Health Threat of Antibiotic Resistance, Gail Haddox (2013) discusses the danger antibiotic resistance poses in today’s society and strategies to prevent the expansion of antibiotic resistance. In Europe alone, an estimated 25,000 deaths have been attributed to multi-resistant infections (Haddox, 2013). Common infections are now harder to treat due to the increased resistance to antibiotics across the world, in fact some are becoming untreatable. Antibiotics should be treated like oil, a non-renewable resource (Haddox, 2013).