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Attention Deficit / Hyperactivity Disorder

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Attention-deficit/hyperactivity disorder (ADHD) can be described as a disorder that affects the central nervous system (CNS). At the current time, the cause of ADHD is still unknown (Mohammadi & Akhondzadeh, 2007). It is considered one of the greatest prevalent chronic health disorders that affect children (ages less than or equal to 17) and rates continue to rise (Mohammadi & Akhondzadeh, 2007). Presently, ADHD has been medically managed by two categories of medications which can be classified as stimulants or nonstimulants. According to the Texas Children’s Medication Algorithm Project (CMAP) (2007) and the Centers for Disease Control and Prevention (CDC) (2015), stimulants continue to be first line choice in treating ADHD and show a…show more content…
Many individuals may assume that it has a better safety profile due to the agent not being a controlled substance, and efficacy still remains questioned (Mohammadi & Akhondzadeh, 2007). In the present paper, the similarities and differences between methylphenidate and atomoxetine will be investigated in regards to efficacy and safety. The following literature that is examined supports methylphenidate’s efficacy over the use of atomoxetine. Furthermore, it also supports there are non-significant differences in terms of the safety profiles when the medications are compared. Efficacy According to CMAP (2007), atomoxetine and methylphenidate have both been approved and have been associated with efficacy in comparison to placebo in treatment of ADHD in children. However, due to the public health concern of the risk of adverse effects such as cardiovascular events and/or abuse potential, research has been conducted to investigate the efficacy between atomoxetine versus methylphenidate. To compare the efficacy of atomoxetine and methylphenidate in the treatment of ADHD in children (younger than 17 years of age), Faraone and Spencer (2006) conducted a meta-analysis. The researchers focused on placebo-controlled studies, and eliminated research that was not double-blind to improve accuracy. The meta-analysis that was performed involved analyzing 29 literatures that focused on the
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