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Sulfamethoxazole-Trimethoprim
Denise L. Camacho
Blackhawk Technical College
Sulfamethoxazole-Trimethoprim
Infections, such as diarrhea and pneumonia, have not always been so easily treated. Today there are drugs, like sulfamethoxazole/trimethoprim (SMX/TMP), which can treat specific strains of these infections; however, before the 20th century, infections were the number one cause of death in the developed world. During the 19th century, scientists began to observe antibacterial chemicals in action. Paul Ehrlich, who was credited for discovering the first modern antibiotic in 1909, also discovered that certain chemical dyes colored some bacterial cells but not others. He then concluded that it was possible to create substances that could …show more content…

It also helps with the prevention of PCP in HIV-positive patients, but should be used cautiously due to the incidence of adverse reactions. This drug is also active against many strains of gram-positive pathogens including: Streptococcus pneumoniae, Staphylococcus aureus, Group A beta-hemolytic streptococci, Nocardia, Enterococcus. It also has activity against many gram-negative pathogens, such as: Acinetobacter, Enterobacter, Klebsiella pneumoniae, Escherichia coli, Proteus mirabilis, Shigella, Xanthomonas maltophilia, and Haemophilus influenzae, including ampicillin-resistant …show more content…

Some other common side effects include: decreased blood pressure (hypotension), fatigue, sensitivity to the sun (photosensitivity), hallucinations, headache, insomnia, mental depression, high blood potassium levels (hyperkalemia), low blood sodium levels (hypernatremia), diarrhea, inflammation of the mouth (stomatitis), inflammation of the liver (hepatitis), and inflammation of the pancreas (pancreatitis), low blood sugar (hypoglycemia), hemolytic anemia, leukopenia, megaloblastic anemia, and thrombocytopenia, and crystals in the urine. Kernicterus can also occur in

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