In the present study, we found that rate of pCR to neoadjuvant chemotherapy was 24.7% (n=25) in the whole cohort (n=101). This finding was consistent with the range of pCR rates to prospective randomized trials of preoperative chemotherapy of 15%-40% mentioned in the literature (Burstein et al., 2008). Moreover, high Ki-67 expression (cutoff >14%) was significantly correlated with achieving a pCR in the large cohort (p=0.016). This result matched with the finding of several studies that reported that
Article I chose for week four assignment, is from The Journal of Public Health," Benign breast disease and subsequent beast cancer". 1. State the type of study that was conducted (see methods section of article, it must be one of the above study types). The article used prospective cohort. After standard data is gathered, subjects in a forthcoming associate study are then taken after "longitudinally," i.e. over a timeframe, for the most part for quite a long time, to figure out whether and when
showed that histone markers effect the expression on target gene, cyclin D1. These ultimately lead to the progression of oral cancer. (Lee et al, 2010). c‑myc was among the first oncogenes found to be amplified in breast cancer, and it can contribute to many other forms of cancer
secondary seeding. During metastasis of breast cancer to lung, interaction of VCAM-1+ cancer cells with VLA-4-expressing macrophages, activates PI3K/Akt signaling in tumor cells, protecting them from caspase-induced apoptosis. Bone metastasis is also facilitated by interaction of VCAM1 with different integrin partner, α4β1, in osteoclasts. Thus, we can conclude that disruption of adhesion signaling between stromal cells and tumor cells can
Breast Cancer is a malignant tumor disease that affects women all around the world. Over 200,000 new cases diagnosed every year here in the United States, and it remains the second leading cause of death among women. (Kaiser, B., & Bouskill, K. 2013). Due to numerous publications in newspapers, magazines, discussions of this issue on television and radio, many women are aware of the existence of breast cancer, however a substantial portion of the female population are not aware of the facts about
public health problems Breast Cancer. It is the most common cancer of women in the world. (Stewart & Wild 2014). Breast cancer can strike all of us and affect families and communities (Australian Institute of Health and Welfare (AIHW) 2012). Discussion and education with Karen will cover her wound care, psychosocial, phantom breast syndrome and prevention of lymphedema. Malignant breast cancer is a serious illness one in eight females
metastases have caused substantial mortality and morbidity in cancer patients. Approximately 15% of women with breast cancer will be diagnosed with brain metastases (Zakaria et al., 2014). With early diagnosis and appropriate treatment, the quality of the patient’s life could be enhanced. Therefore, it is vital for patients with a known primary tumour to undergo imaging studies once they develop neurological signs and symptoms. Imaging studies aid to accurately identify the type, number, size, and location
Adult Case Study: Male Breast Cancer Carly Regan Loyola University Chicago Introduction Overview When the topic of breast cancer is discussed in conversation, most will think of it as a female diagnosis. While the greatest percentages of patients diagnosed with breast cancer are female, it is still possible that males can be diagnosed. It is a diagnosis that practitioners should always keep in the back of their minds as a differential when a male presents with a breast
quality cancer care (IOM, 2001) requires the understanding of the interacting factors (e.g. screening) and outcome (Lemon et al., 2003). Disparities in breast cancer care exist (Goss et al., 2011), moreover, patients with this disease fail to receive high-quality end of life care (e.g. pain and symptom management, end of life decision-making) (Katz & Hofer, 1994). Leaders in the care field need to create new strategies for the organizations in order to increase the care quality through the cancer treatment
offering relatively free and cheap healthcare to the needy members of the society. There major focus is to help the society manage and control the health detrimental diseases including the cancers and malaria. For the interview, I had approached one of the healthcare practitioners from the departments of the breast cancer screening and treatment. The interview is senior worker having worked with organization for over twenty-five years. His name is Doctor Smith currently serving the organization consulting