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Burst Ketamine: A N-Methyl-D-A

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Ketamine is an N-methyl-D-aspartate (NMDA) receptor antagonist. It is thought that Ketamine helps to improve analgesia in those with pain refractory to high dose opiates as studied by Yang et al (1996) Mercadante et al (2009) explain that this could be due to a possible reversal of opioid tolerance. Normal doses can vary and Ketamine can be given in tablet form, as a subcutaneous “burst” or intravenously. The normal dose can range from 40-3200mg daily. Mercadante et al (2009) also outline that there may be a possibility that single dose ketamine may reduce hyperalgesia but more studies need to be done to confirm this. In this case, we used Burst Ketamine starting at a dose of 100mg with a view to increasing up to 5oomg over the course of 5 …show more content…

We often talk about intractable symptoms such as intractable pain or vomiting, however we also need to consider intractable existential suffering. Cherney et al (1994) explain that existential suffering can be just as distressful as the physical symptoms and suggests that clinicians should consider palliative sedation. However, this is often a complex ethical issue as patients are not always at the end of their life, they can be alert and active thus making palliative sedation ethically worrying and should only be done when all other options have been considered. We did not really consider palliative sedation in this case because the patient was still ambulant and able to enjoy visiting home or going out with his family, however with hindsight maybe we should have trialled a low dose of sedation to see if it made any difference to his distress. We were also late in the referral for counselling as well as the addition of an SSRI, I believe this was due to a focus on the physical symptoms and a lack of awareness by …show more content…

In this case, we need to consider our limited resources (being a 10-bedded unit) and our other patients/referrals. As a team, we felt that this was difficult as SD was not symptom controlled but there was a phase of around 2 weeks where he had reached a plateau with regards to his pain. This was perceived to mean that he was stable but in effect he was still being treated for psychological issues and existential distress. These symptoms were considered by some to be less important than the physical ones however I feel that any patient suffering from intractable physical or psychological symptoms should not be discharged unless it is their wishes. We did have to move SD into various bed spaces to accommodate other patients, this was handled well by staff but not received well by SD. We also could have considered using palliative sedation which is ethically difficult as giving sedation to someone that is otherwise bright and alert is however if the rationale is justified and the providing the drug is used at the correct dose for the treatment of a symptom then it is not actually harming the patient therefore non-maleficence is a factor and indeed the hope would be beneficence by way of controlling their symptom. In this case, we did not use sedation as the patient’s autonomy was respected and

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