C. Ancer: A Case Study

Cancer, medically called ‘tumorigenesis’ (Thaker, Lutgendorf, & Sood, 2007, p.430) occurs when cells in the body orient themselves for malignant growth. Such cells show ‘self-sufficiency in growth signals’, are ‘insensitive to anti-growth signals’ and have ‘limitless replicative potential’ (Thaker, Lutgendorf, & Sood, 2007, p.430). Once a particular set of cells become malignant, the malignancy can spread to other set of cells in different organs due to ‘crosstalk’ between the affected cells and their surrounding ‘tissues’ and ‘micro-environments’(Thaker, Lutgendorf, & Sood, 2007, p.430).

The cell cycle has four main stages. The cell cycle is the regular pattern of growth. The four stages consist of Gap 1 (G1), Synthesis (S), Gap 2 (G2), and Mitosis (M). Gap 1, consists of a cell that carries its normal functions. Calls also increase in size, and the organelles increase in number. A cell will spend the most time in this phase. But it also depends on the cell type to see how long it will spend in this phase. During this phase the cell has to pass a critical checkpoint before it can continue into the (S) stage, also called the Synthesis stage. It would be dangerous for a cell to keep dividing if the certain conditions were not met. The cells in this stage also need signals from the other cells to tell the if division is needed. Now the next stage is the Synthesis stage. During this phase the cell makes a copy of it’s nuclear DNA. By the end of the (S) phase DNA appears grainy in photos and the cell nucleus contains two complete sets of DNA. Gap 2, is the third stage of the cell cycle. The cells continue doing there thing and more growth occurs. This phase is like the checkpoint, everything in the cell has to be going right for the cell to be able to enter mitosis.

Cancer is defined by the National Cancer Institute as the title given to a group of related diseases. All types of cancer are categorized by uncontrollable growth of cells that metastasize to surrounding tissues. Cancer can develop at almost any part of the human body and anyone can develop cancer, although risk typically increases with age because most cancers tend to require many years to develop. ?Typically, human cells tend to grow and divide and ultimately form new cells as the body needs them. When an organisms cells grow old or get damaged, the cells die, and new ones replace them. However when cancer develops, this orderly process gets reformatted. As cells increasingly get more irregular, old or damaged cells begin to survive when they should die, and new cells develop in the body when there is no need for them. These abnormal cells have the ability to divide without stopping and tend to result in growths called tumors?(cancer.gov). Cancerous tumors are defined as malignant meaning that they can spread to nearby tissues or metastasize to distant places in places within the body and form new cancerous tumors. There are over 100 forms of cancer and they are usually named after the organs or tissues where the cancers originate. Staging of cancer is used when describing the severity of a person?s cancer and is based upon the following

Cancer, as it invades in its place of origin, may also work its way into blood vessels. If this occurs, it provides yet another route for the cancer to spread to other organs of the body. When the cancer spreads elsewhere in the body, it has become systemic in extent and the tumor growing elsewhere is known as a metastasis.

Cancer is defined by the National Cancer Institute as “the name given to a collection of related diseases. In all types of cancer, some of the body’s cells begin to divide without stopping and spread into surrounding tissues.” Cancer can develop at almost any part of the human body and anyone can develop cancer, although risk typically increases with age because most cancers tend to require many years to develop. “Normally, human cells grow and divide to form new cells as the body needs them. When cells grow old or become damaged, they die, and new cells take their place. When cancer develops, however, this orderly process breaks down. As cells become more and more abnormal, old or damaged cells survive when they should die, and new cells form when they are not needed. These extra cells can divide without stopping and may form growths called tumors” (cancer.gov). Cancerous tumors are defined as malignant meaning that they can spread to nearby tissues or metastasize to distant places in places within the body and form new cancerous tumors. There are over 100 forms of cancer and they are usually named after the organs or tissues where the cancers originate. Staging of cancer is used to “describe the severity of a person’s cancer based on the size and/or extent (reach) of the original (primary) tumor and whether or not cancer has spread in the body” (cancer.gov). The importance’s of staging cancer is to assist the doctor with planning appropriate treatments to fight the cancer

If a tumor is malignant, the cancer cells can break off and spread to nearby tissues and through the blood and lymphatic systems to other parts of the body, such as the liver, bones, lungs or brain. When they reach the new site, the cancer cells settle and grow much like a dandelion seed, forming another tumor in the new location. This is called metastatic cancer or sometime “Stage Four Cancer”.

The cell cycle will stop at the G1 phase and will be unable to proceed to the synthesis stage

four stages. It usually starts as tumor cells such as common epithelial, germ cells, and

The last potential method is through the blood, which takes advantage of blood vessels to spread cancer cells and allows it to invade other parts of the body.

A normal cell replicates and divides into two cells which in turn divide into four daughter cells and so on by DNA replication in mitosis. As the cell grows old, it dies because of the programmed cell death known as apoptosis. The dead cells are then replaced with new cells. However when the DNA of the cell is damaged, for example when there is a genetic change such as DNA mutation or defective protein synthesis, the cell becomes abnormal. It begins to divide uncontrollably and forms a growth (cancerous tumour), in contrast to the normal cell in which

Cancer is described as an uncontrollable division of cells. According to the National Cancer Institute, cancer is one of the leading causes of death in the world, with an estimated 595,690 deaths and 1,685,210 new cases in 2016 alone (NIH 2015). Cancer can develop from almost every organ of the body, with the most common organs affected being the breasts, lungs, prostate, colon, and bladder (NIH 2015). As the disease progresses, it may become metastatic, where the cancer cells migrate from their point of origin to other parts of the body. Cancer can spread in three ways: through tissue, through the lymph system, and through the blood (NIH 2015). When cancer progresses to a metastatic state, it is

Metastasis is a sequence of phases in which cancer cell span from the primary tumor site to other regions through lymphatics, blood or direct extension. In this process malignant cells degrade from the original tumor and bind to proteins found within the extracellular matrix, degrading them. During this degradation, malignant cells infringe the extracellular matrix

The cell cycle is separated into multiple stages such as G0, G1, S, G2, and M phase. During the G0 phase is the stage in which there is no sign of the cell preparing to separate but, rather a stagnant cell. The G1 phase involves the expansion of the cell and gathering all the nutrients and energy to prepare for the upcoming processes of the cell cycle. In the S phase,

Cell cycle is the order of events that takes place in a cell in groundwork for cell division. The cell cycle is a process of four stages. In each of the stage in which the cell increases in size (G1), copies its DNA(S), prepares to divide (G2), and divides(Mitosis). Mitosis itself have four stages. First is prophase, in which chromosomes are condensed, homologous chromosomes are paired together, and the spindle apparatus made of microtubules forms. Second is metaphase, in which the paired chromosomes are lined up across the center of the cell on the metaphase plate. Third is anaphase, in which the homologous chromosomes are pulled to separate poles in the dividing cell by the attached spindle apparatus. Fourth one is the telophase, in which the daughter cell chromosomes are collected together at the poles. These stages make up interphase, which credits for the distance among cell divisions. In other words, cell cycle is the process in which parent cell divides and produces new cells, called daughter cells. The main concern of cell division is the maintenance of the original cell's Genome (genes).

PhaseIIIb: The cancer spreads as way because the girdIe waII and to the bodiIyfIuid nodes however to not differentcomponents of the patient’s body (T1, T2, or T3a; N1,