The CM data (code C43, the International Classification of Diseases10th revision) registered from 1983 to 2013 were derived from Hong Kong Cancer Registry, Hospital Authority (http://www3.ha.org.hk/cancereg/c_a1b.asp, accessed 18th, June, 2016). Briefly, the Hospital Authority manages the Hong Kong’s public hospital services, and the Hong Kong Cancer Registry is a population-based cancer registry and a member of the International Association of Cancer Registries. The full dataset used in this study was attached as the Supplemental Table S1 and Supplemental Table S2. It contains the following categories: sex, five-year age groups, diagnosed cases, deaths, and age standardized rates (ASRs, per 100,000 person-years) of incidence and …show more content…
Five sub-models were arranged in the sequence with all relevant test: Age, Age-drift, Age-Cohort, Age-Period-Cohort, and Age-Period. The likelihood-ratio test derived from the deviance statistic was used to choose the best fitting model [31, 32] by assessing likelihood-based deviance statistics and penalizing additional degrees of freedom starting from an age parameter only. Finally, the five sub-models above estimated the effects of drift, cohort, period and cohort, and period in sequence. The effects of age, period and cohort were calculated as the rates for reference period, rate ratio relative to the reference period (2000), and rate ratio relative to the reference cohort with (1960), respectively. All above was implemented with the “apc.fit” function in the “Epi” package [33] in the R software [34].
2.4 Case fatality ratio
The case fatality ration was defined as the proportion of deaths over the new cases in a period. It is expressed as a percentage and represents the risk of the CM.
3. Results
3.1 Annual percentage change in incidence and mortality of cutaneous melanoma in Hong Kong (1983-2013)
A total of 767 deaths and 1688 cases of incidence were registered between 1983 and 2013 in Hong Kong (Table 1). Both incidences and deaths in males were greater than female. The deaths were with a male:female
For our analysis, we used cohort data from the Surveillance, Epidemiology, and End Results (SEER9) Program of the National Cancer Institute with data spanning from 1973-2012. The SEER database collects cancer surveillance data from population-based cancer registries in the United States with an approximate coverage of 30% of the entire US population. This data is de-identified and publicly available data and therefore did not require the approval of an institutional review board.
In the United States, for the year 20151 it has been estimated that there were 73,870 new cases of invasive CM. 63,440 new czars of in situ CM, and 9,940 new CM-related deaths. Based on 2010-2012 data., the risk of eventually developing CM For all races was one in 48. More than 984 of CM cases 042Cur I.13 whites. Based on 2012 data.. there were approximately 996,600 people living with CM.
"The rates of skin cancer have expanded consistently since the 1920s uncovers the risk of the American fixation on getting a "solid" tan. Skin tumor is an infection where growth (harmful) cells are found on the external layer of the skin (epidermis). The three sorts of cells found in the epidermis are squamous cells, basal cells, and melanocytes. These cells in time develop to be carcinogenic. Consequently, the three sorts of skin tumors are squamous cell, basal cell, and melanoma. Melanoma is the deadliest and dangerous kind of growth. The quantity of individuals with melanoma has ascended in Scotland from 3.5 in 1979 to 10.6 for each 100,000 in 1998 for men and 7.0 to 13.1 for ladies. (Mill operator 945) Squamous cell and Basal cell skin
Malignant melanoma is the most commonly seen skin cancer and it has the highest number of deaths among diseases of the skin (Friedman, Rigel, Kopf and Polsky, 2005). Among the many factors that cause this cutaneous cancer genetic modifications, viruses, carcinogens and excessive exposure to ultraviolet rays are the most commonly occurring (Friedman, Rigel, Kopf and Polsky, 2005). Malignant melanoma affects all areas of the skin and the disease forms in melanocytes, which are the cells in which pigments (melanin) are synthesized (Melanoma Treatment). The cancer has its origin in the epidermis and affect squamous and basal cells. The disease usually affects the trunk, arms and legs but can also be present in the eye, affecting the
Skin Cancer is the abnormal division of skin cells which cause tumors in the body. There are 3 types of Skin Cancer: Melanoma, Basal cell carcinoma, and squamous cell carcinoma (Web Md, year). Skin cancer is caused by the exposure of ultraviolet radiation and UV-like factors (Skin Cancer Foundation, 2015). This paper focuses on a specific type of skin cancer called Melanoma.
Melanoma is a very serious type of skin cancer and can be extremely dangerous if it’s not taken care of properly. Melanoma usually develops in the melanocyte cells when the skin has been exposed to ultraviolet radiation from tanning beds or from being outside in the direct sunlight for too long or over a long period of time. When unrepaired skin DNA becomes too damaged, it can trigger a mutation in the cells which leads to the skin cells to rapidly multiply, turning into the cancerous growths. In some cases, melanoma can form in the eyes, nose, mouth, genitals and, in rare situations, form in the intestines (Mayo Clinic).
The cohort component approach has three main components: births, deaths, and migration. The cohort component model uses these three components to move age/sex cohorts forward through time, creating a new age/sex distribution at each five-year time point. The success of the model depends on identifying appropriate fertility, mortality, and migration rates to apply to different age
The outcome of interest in this study was to identify a population at a higher risk for malignant melanoma, and develop a clinical screening tool that could earlier detect malignant melanoma in this high-risk population. Another outcome of interest was to determine the effectiveness of total skin examination in detecting malignant melanoma in these high-risk groups, with the hope of detecting the melanoma earlier so that patients can be treated more effectively. This would be important to patients because the earlier detection of malignant melanoma from screening high-risk populations would allow for earlier treatment, thus hopefully decreasing the mortality rates in patients with malignant melanoma.
Typically, people with fair skin, light colored eyes and hair, have freckles and burn easily instead of tanning are more likely to get malignant melanoma than anyone else. Although melanoma accounts for less than 2% of skin cancers, it is responsible for the clear majority of deaths from skin cancers (Tan, 2016). The American Cancer Society (2016) estimates that the current year about 76,000 new cases will be diagnosed and that there will be around 10,000 deaths due to this. Worldwide, the occurrence of malignant melanoma cases has been rapidly increasing, and it is doing so faster than any other cancer besides lung cancer in women. Queensland, Australia and Israel have the highest occurrence of melanoma in the world (Tan, 2016). Melanoma can affect anyone of any race or age it rarely effects children under the age of ten. The average age to be diagnosed with it is 57 years old and women usually get diagnosed at an earlier age then men, usually before the age of
Melanoma is a skin cancer that develops in pigment cells. These pigment cells are called melanocytes. These cells can grow rapidly and can spread throughout the lymphatic system. Early detection is a key factor when dealing with melanoma. The survival rate is determined by how early the cancer is diagnosed. If the cancer is caught at an early stage the survival rate is about 99%, but if it is not and it spreads throughout the lymphatic system, the survival rate drops to 14%. Melanoma is less common than most cancers but is one of the most dangerous cancers. Melanoma is caused by the exposure to ultraviolet from the sun and sunbeds. Sunburns that repeatedly occur can eventually cause the development of Melanoma. Melanoma can start off as just
Melanoma is one of the rare diseases of the integumentary system; it is also the deadliest. It is a form of skin cancer and is held responsible for most skin-cancer related deaths. The three major forms of melanoma are: cutaneous melanoma, ocular melanoma, and mucosal melanoma. More and more cases of melanoma have been occurring throughout the years. In the early 2000’s over 160,000 new cases of this deadly disease popped up. It is ranked the sixth most common cancer in both genders. While it does occur slightly more in women, the deaths caused by it is higher for men. This form of cancer is more popular with the white population. It more so affects these whites in North America, Oceania, and Europe.
Melanoma, a type of skin cancer that normally starts in the melanocytes, a type of skin cell. In the past few years, doctors have noticed a spike in the number of cases of Melanoma. Many things can cause Melanoma, such as sun exposure or even laying in tanning beds. The use of tanning beds is the one of the large reasons why doctors believe this spike has occurred. Men are more venerable to skin cancer than women are, although women who tan are obviously more prone to getting this type of skin cancer. In the past few years, doctors have seen a rise in middle-aged women. Also compared to the 1970s doctor’s suspect that the way our clothes and bathing suits are designed now days could have something to do with this increase. The bathing
Have you ever wondered what the less common cancer that hits our skin is? This type of cancer is called Malignant Melanoma. According to the “American Cancer Society” “Malignant Melanoma are from moles that don’t make enough melanin and do make melanin from the skin (2015). From the “American Cancer Society “says that “UV Rays from the sunlight is another type that does cause Malignant Melanoma”(2015). “American Cancer Society” say that the Melanocytes are protected by the dermis, the deepest layer of the skin (2015). From the “American Cancer Society” “Estimates that over 76,830 about 46,870 men and 29,510 women will get diagnose and about 10,130 about 6,750 men and 29,510 women will die from melanoma (2015). Cancer Society statistics states that the most common to find the cancer in is white than African Americans and the average age is 63 and the common in the younger to find this type of cancer is 30 (American
Melanoma is the least common type of skin cancer, but it is as serious as most common skin cancer. Melanoma has many risk factors, including one of the most common one that should be avoided and that is the overexposure to the sun. Melanoma is caused by the pigment cells that eventually form into cancerous cells. Melanoma cancer is known to be dangerous because it spreads into the person’s body. Melanoma does not discriminate against skin types so anyone is prone to this particular cancer. Individuals who are at a higher risk are people who spends more time in the sun than they should.
In recent years, cancer prevalence has been increasing globally. It is now one of the top 10 causes of death among the middle and high income countries worldwide (World Health Organisation, 2008). In Singapore, cancer has surpassed cardiovascular disease and become the top killer over the last 3 years (Ministry of Health, 2007). Breast cancer tops the chart among Singaporean women (Health Promotion Board, 2007). Thousands of women are diagnosed with breast cancer annually and it causes approximately 270 deaths each year (Jara-Lazaro, et al., 2010). The lifetime risk that a woman in Singapore getting breast cancer is now 1 in every 17 which has risen compared to past two decades (National Cancer Centre Singapore, 2006). Hence, breast