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Causes Of Huntington Disease

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Huntington disease (HD) is a genetic disorder characterized by the progressive loss of neurons in the brain. It is caused by expansion of CAG repeats in exon 1 of the huntingtin gene, affecting initially the striatum and progressively the cortex. OS is known to play a role in this disease by promoting mutant Huntingtin aggregation and mutant Huntingtin-dependent cell death by mimicking proteasomal malfunction [24]. Several laboratories have demonstrated the existence of oxidative damage in HD brains [30–33] and those antioxidants slow down disease progression [34]. In HD, the initial cause of oxidative insult is the presence of mutant Htt, which has been shown to increase levels of ROS in neuronal and nonneuronal cells [18]. The level of 8-hydroxydeoxyguanosine,
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