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Cytokines And Antibodies-Protein Synthesis

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Starts with environmental trigger such as sunlight expose which damage cells and cause apoptosis and the release of nuclear antigens. These stimuli begin a reaction that leads to distrupting to other cells in the body and exposure of their DNA, histones, and other proteins, particularly part of the cell nucleus. In individuals with lupus, both B-cells and T-cells become overactive. The two main consequences of this increased activity are the production of antibodies that recognize and destroy the body’s own cells and inflammation and can lead to long-term, irreversible scarring. The body’s sensitized B-lymphocyte cells will produce antibodies against these nuclear.
These antibodies clump into antibody-protein complexes which stick to surfaces
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Some people with lupus have a greater ratio of proinflammatory to anti-inflammatory cytokines than normal individuals, which produces an unbalanced regulatory mechanism. While an overall cause-and-effect relationship between cytokines and lupus is not yet understood, certain cytokines called interferons and interleukins are associated with the disease. Complement protein interact in a sequential manner to clear immune complexes from our body. Deficiencies of certain complement proteins are associated with lupus. In addition, since complement proteins are consumed during inflammatory processes, low complement levels may indicate lupus…show more content…
The Infection Fighter B cells and T cells are two important components of the immune system. They play a role in the inflammation associated with lupus. Both B cells and T cells associate immune cells called lymphocytes. Lymphocytes help fight infection. B cells and T cells are involved in the immune system's response to infection. Antigens are foreign bodies (such as bacteria and viruses) that stimulate the immune system to produce autoantibodies. When a T cell recognizes an antigen it will produce chemicals (cytokines) that cause B cells to multiply and release many immune proteins (antibodies). These antibodies circulate generally in the bloodstream, recognizing the foreign particles and triggering
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