Dermatofibrosarcoma protuberans (DFSP) was first described by Darier and Ferrand in 1924 [14]. DFSPs are rare monoclonal cutaneous soft tissue sarcomas of intermediate malignancy [1]. These locally aggressive spindle cell tumours tend to recur after conservative initial surgical intervention [2]. 10–15% of DFSP are high-grade variants associated with local recurrence and metastasis, and the remaining 85–90% are low-grade. It is a tumour of the deep dermis and subcutaneous tissue and when found in the breast, rarely involves the mammary glands. [16,19]
Epidemiology:
DFSP accounts for less than 0.1% of all malignancies and approximately 1% of all soft tissue sarcomas [14]. The incidence has been reported between 0.8–5.0 cases per 1 million persons per year. DFSP affects both men and women equally and has been documented in all races. DFSP most commonly occurs in adults between the ages of 20 and 50. Cases ranging from birth up to 80 years of age have been reported, but these are exceedingly rare. [4,14]
Pathogenesis:
Trauma has been documented as a triggering factor in 10 to 20% of cases. Reports also describe tumour development in scars from previous operations, burn wounds, varicella or BGC immunizations, and rapid growth during pregnancy (due to progesterone receptors in the tumour). DFSP has been
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They are initially asymptomatic and slowly progressive but many go on to ulcerate, bleed or become painful. These lesions grow slowly over months to several decades and eventually develop rubbery nodules within plaques. Growth often accelerates once nodules appear [14]. These lesions usually vary in size from 1–5 cm but can reach 20 cm or more in advanced cases. [10,14] DFSP are most commonly located on the trunk (50 to 60%), proximal extremities (20%), and head and neck (10 to 15%). [13] Acral and genital DFSPs are
The Georgia Department of Human Services [DHS] has many divisions that are to assist the people of the State of Georgia with different necessities they may need. For instance, there is the Division of Aging Services that caters specifically to the elderly and to report elder abuse. With a total of three divisions and eight offices, this specific department also houses the Division of Family and Children Services [DFCS]. These representatives and workers do what they can by all means necessary when it comes to the care and welfare of children of the state. However, there are times when they fall short of their jobs
In the twenty-first century there is a plethora of drugs distributing from Mexico to the United States all the way to Canada causing numerous people to be sentenced to prison, to depart from their families, and to even die. Luckily, there is one law enforcement agency created by the U.S. government to banish these horrible facets, the Drug Enforcement Administration (DEA). Breaking down and destroying drug empires, arresting the kingpin leaders of illegal narcotics, and trying to put an end to this terrorizing crime. Drug cartels have always been an enormous issue all across the globe, but the DEA is like the superhero trying to fight
What are the most common genetic/chromosome changes related to this form of cancer? Which genes are responsible? Where are these genes located? How are the genes different from normal individuals?
BOOM! CRACK! The fireworks in the distance looked beautiful reflecting over the lake. It was the first time the five of us had gotten together in a while. We were all enjoying our day, but Paul had suddenly disappeared. I went looking for him. I found him and he asked me to stay with him so he wouldn’t be alone. This story is not uncommon among many veterans. After a war many veterans come home with PTSD or Post Traumatic Stress Disorder. PTSD is a disorder that people who experience traumatic events can receive. To understand PTDS, first one must comprehend the disease and its causes, how it affects the victim, and how it is currently treated.
The aim of NFIP is to reduce the losses regarding flood damage through community flood plain management which also provides protection for property owners regarding flood insurance.According to the agreement between local communities and Federal Government will provide management of flood insurance within the community for financial protection against flood losses if a community will make a floodplain management to reduce future flood risks to new construction in Special Flood Hazards Areas.
In the United States, more than 58 million citizens live in areas that are classified as primary care shortage areas. These regions, official labeled Health Professional Shortage Areas (HPSAs), fail to maintain a sufficient talent pool of primary care providers as outlined by federal guidelines. According to a report issued by the Kaiser Foundation, Advanced Practice Nurses (APNs) have the potential to fill this void. As of 2012, approximately 127,000 APNs deliver treatment in the country and 60,400 of those practitioners server as primary care providers (PCPs). Although these professionals can serve as a viable solution to the care shortage in the United States,
SUBJECT: Information Paper on the criticality of DCIPS 1. Purpose: To provide the Brigade Commander current information on Defense Casualty Information Processing System – Forward (DCIPS-FWD). 2. Facts: a. The Defense Casualty Information Processing System – Forward (DCIPS- FWD) is a multiple-component base system used by the Department of Defense for casualty reporting during both peace time operations and mobilization deployments.
Tolkien did a very good job of portraying the elves a good people,I know this because the dwarves and elves hate each other the elves give the dwarves a place to stay and food.The dwarves and elves hate each other because the elven king did not risk his army´s life when the dwarves got attacked by the dragon.Also the elven king Elrond reads the moon letters that are on the plan of the mountain, tells Thorin and Gandalf the magical properties of their swords which is that Biter (Thorin's sword) and Foe-Hammer (Gandalf´s sword ) glow blue when orcs or goblins are nearby, and he gives Gandalf a white horse.The elves are likeable people because they avoid war if possible and are always
Dysport is an FDA approved injectable that is very effective in significantly reducing facial lines and wrinkles. Moreover, this treatment will help in getting rid of crow's feet, deep creases, worry lines among many others, and will make you look refreshed and relaxed. Besides, Dysport functions in a similar manner as Botox, by blocking the nerve signals. Add to that, with Dysport, you can see results within couple of days, and sometimes as quickly as less than one day.
In this cross-sectional study, 12.4% of the DM patients reported at least one benign tumor, and 6.2% reported at least one malignant tumor. In the multivariable analysis, we found that older patient age and younger age at DM diagnosis were associated with both benign and malignant tumors, while gender was associated with benign tumors only. We found no statistically significant associations between reported tumors and evaluated lifestyle factors
The deadly disease, known as Kaposi Sarcoma, was first discovered by Moritz Kaposi and later named after the discoverer himself. Moritz Kaposi was a Hungarian physician and dermatologist and he first discovered the disease in 1872 describing it as an idiopathic multiple pigmented sarcoma of the skin. He studied the affliction on five elderly male patients. Moritz continued to describe the various characteristics of the disease including nodules developing on the skin, mainly on the hands and feet, tinted in either blue-red or brown-red forms. Moritz continued to describe the behavior of the nodules by describing two scenarios. One in which the nodules remain isolate and begin to protrude growing in a spherical shape. Another scenario involves the nodules multiplying in number but remaining flat in the skin. Generally the nodules begin to form on the instep of the foot and soon after develop on the hands. As the disease progresses, the formations tend to group around several areas including the arms, legs, face, and trunk except they cluster in irregular patterns and in smaller numbers as well.
Rhabdomyosarcoma is a tumor of undifferentiated skeletal muscle and is considered to be the most common soft tissue sarcoma in children, representing 3% of all pediatric malignancies in the United States (Ojo, Chen, Pelaez, & Younis, 2014). RMS is more common in Caucasians than African Americans (3:1) and in males than females (1.5:1) (Wang, 2011). In order to accurately diagnose rhabdomyosarcoma a thorough clinical workup is performed. The workup begins with a clinical examination and history, where gathering information such as family history of genetic syndromes, associated conditions and signs and symptoms are crucial. Research has revealed negative association between RMS and environmental factors, however, a family genetic history of neurofibromatosis (NF1), Li-Fraumeni syndrome,
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One means in which USFSP utilizes data analytics is by keeping record of students’ personal information such as employment, current location and education history, to not only better understand their student body, but also understand their educational needs. Accessing these statistics is a primary reason why the majority of USFSP MBA candidates are participating in the online program, considering that many of them might lack the time and financial resources to study full-time at a big-name university. To come to this conclusion, university officials would have to analyze national trends in postgraduate education and formulate decisions best suited to satisfy the needs of their primary clientele base. As a current student, I believe that
Forceps are instruments that look like two large spoons. They are used by health care providers during the second stage of labor. This is the stage of labor at which the cervix is completely open (dilated). Forceps-assisted delivery is used in a medical emergency, when your health or the health of your fetus (baby) requires your health care provider to act quickly to help you deliver your baby. The main benefit of this type of delivery is that it helps you avoid a cesarean delivery, which is a major surgery with longer recovery time.