Diabetes Mellitus ( Iddm )

When the blood glucose levels rise above the optimum, the pancreas detects this, and sends a metabolic signal for the pancreas to produce insulin in the beta cells. The beta cells are a part of a cluster of cells called the Islets of Langerhan. The hormone insulin is made here because the pancreas is a part of the endocrine system. (4) Insulin helps our cells convert glucose into energy, and it helps our bodies store extra glucose for use later. Insulin does this by turning the extra food into larger packages of glucose called glycogen. Glycogen is stored in the liver and muscles. When the body consumes food the pancreas will produce more insulin than normal as more is needed, and less insulin when it is not needed as much. (7)

     Diabetes mellitus is a group of metabolic disorders characterized by inadequate insulin secretion by the pancreas or cellular destruction leading to an insulin deficiency. Depending on the cause of the insulin shortage, diabetes can be subcategorized into type I and type II. Type I diabetes (T1DM) is usually mediated by the destruction of b-cells in the pancreas resulting in decreased insulin production and secretion. Type II diabetes (T2DM) is the failure of these b-cells to secrete adequate amounts of insulin to compensate for insulin resistance and increased gluconeogenesis combined with an overall resistance to the insulin action (8., 1997). T2DM accounts

Diabetes Mellitus is the metabolic disorder characterized by high levels of blood glucose that is caused by deficiency of production of insulin, action of insulin, or may be both of them. The uncontrollable output of hepatic glucose and reduced uptake of glucose by the skeletal muscle with reduced synthesis of glycogen lead to hyperglycaemia. Diabetes is a complicated disease; it can affect mostly every organ of our body and causes devastating consequences.

Diabetes Mellitus (DM) or Type 2 Diabetes is seen as a metabolic disease that is categorized by abnormally high blood glucose or hyperglycemia. Diabetes Mellitus is also formerly known as noninsulin-dependent diabetes mellitus and is the most common form of diabetes that is seen. Insulin is a hormone that is supplied to the body that allows us to efficiently use glucose as fuel. When carbohydrates are broken down into sugars in the stomach glucose enters the blood circulation simulating the pancreas to release insulin in an appropriate amount to become used for energy. With diabetes mellitus the body does not properly make use of the insulin supplied for the body. This causes the pancreas to produced an extra amount if insulin which the body cannot keep up with, causing an imbalance to the blood glucose levels (American Diabetes Association, 2015). In the united states diabetes affects almost 29.1 million people, while the another 86 million people have pre-diabetes but do not know. It is also known as the 7th leading cause of death in the country in the recent years (MedicineNet.com, 2016). For a patient suffering from a chronic form of diabetes mellitus understanding how these mechanisms lead to the condition can be used as preventative measures. Potential consequences as well as the causes and clinical manifestations will ensure a better knowledge on the issue to monitor the condition.

Type II Diabetes Mellitus (DM) is a chronic disease that influences the physical and social aspects of life for millions of people living in New York City (NYC). The excess accumulation of glucose in the blood caused by this disease can lead to the breakdown of many organs in the human body leading to increased hospitalizations and mortality. Although diabetes is a manageable disease given the appropriate care and education, the disease and its complications disproportionately affect African-Americans or non-Hispanic blacks then any other ethnic group in NYC. The NYC Department of Health & Mental Hygiene (DOHMH) reports death rates among black New Yorkers are higher than among whites, regardless of neighborhood income. There is a significant number of non-Hispanic blacks afflicted in low-income neighborhoods due to the environmental injustices such as lack of fresh food options, neighborhood poverty, and limited recreational space for physical activity and exercise. With lifestyle modification as the mainstay of treatment, recognizing the environmental deficiencies and rectifying these problems at the local and federal levels will help to decrease this health disparity.

Type I Diabetes was once referred to as Juvenile Diabetes or Insulin Dependent type Diabetes Mellitus (IDDM). Type 1 diabetes, is an incurable but treatable disease which can occur at any age but is mostly found in children. Couch et al. (2008) states, “Juvenile diabetes affects about 1 in every 400-600 children and more than 13,000 are diagnosed yearly” (pg. 1). A 2014 CDC fact sheet concerning diabetes, showed that, “In adults, type 1 diabetes accounts for approximately 5% of all diagnosed cases of diabetes in the United States.” It seems that we all know someone who is affected by diabetes; either type 1 or type 2. Diabetes seems to be such a common-place illness and is much more prevalent in today’s society. However, this hasn’t always been the case. Gale (2002), states, “At the start of the 20th century, childhood diabetes was rare… (pg. 3353).” In this paper, I will provide information about Juvenile or Type I diabetes in order to educate the reader about this illness.

Diabetes mellitus is a chronic disease that involves the changes of blood glucose level in body systems. This disease usually inherited from generation to generation and sometimes it is due to lack of insulin produced by the pancreas. As the insulin produced is decreased, the blood glucose level will increase thus distressing the metabolism and damaging the body’s systems especially the blood vessels in kidneys, hearts, eyes and nervous systems (Nagappa et al., 2003).This disease have three different subtypes, type I (insulin dependent diabetes mellitus, IDDM), type II (non-insulin dependent diabetes mellitus, NIDDM) and gestational diabetes mellitus.

Moving on to Non Insulin Dependent Diabetes Mellitus (NIDDM) or Type II Diabetes , this form develops usually later on as an adult, however, there has been an increase in teens developing Type II diabetes due to the lack of exercise and poor eating habits which turns into a higher body weight. In this type of Diabetes, the problem is that the pancreas does still produce insulin but not enough for the body’s needs. The signs and symptoms of Type II are pretty much the same as Type I. There is increased urination, thirst, hunger, weight loss, blurred vision and so on. The differences, between

Glucagon is the other hormone produced by the Islets of Langerhans. This hormone is produced by the alpha cells in the islets, which detect when blood sugar levels are too low (around 70 mg/dL) and respond by releasing glucagon. Glucagon stimulates the breakdown of stored glycogen into glucose through a process called glycogenolysis, and releases the glucose back into the bloodstream, thus raising blood sugar levels to a higher concentration. As blood glucose levels return to its equilibrium, the concentration of glucagon lowers until the time when glucose levels rise again. In reaction to this, insulin levels rise and fall with the levels of blood glucose concentration.

Type II is similar to Type I but this particular branch is known as a Non-Insulin Dependent Diabetes Mellitus (NIDDM), meaning that the production of insulin is not the problem. Patients with type II have an insulin resistance condition, which means that their body has become resistant to the insulin hormone and therefore, the cells in the body do not react to it. When resistance to insulin takes place, the pancreas makes an effort to produce as much insulin as it can, in order to attempt to stimulate the body’s cells, until it can no longer produce sufficient amounts. Once the insulin production has worn out, blood sugar levels in the bloodstream rise and diabetes type II manifests. Insulin levels in the body may be normal but because of the resistance, there is a decrease in sensitivity to liver and muscle cells, and because the insulin cannot penetrate such muscles, it becomes ineffective. Unlike type I, type II can be

Type 1 Diabetes occurs when the insulin producing beta cells also know as islet cells, produced in the islet of langethan, are attacked in the pancreases resulting in little to no insulin production. This leads to elevated levels of blood glucose (more than 8mmol/L) and if left uncontrolled multiple complications arise (reference NPS MIDICE WISE).

The pancreas is a gland that is below and behind the stomach, which is where the hormone insulin comes from. The pancreas puts insulin into the bloodstream, and as the insulin moves around, it is allowing sugar to enter the cells. Having insulin is necessary as it lowers the amount of sugar in the bloodstream, and “as your blood sugar level drops, so does the secretion of insulin from your pancreas.”

Approximately 90% of the pancreas is exocrine. The remaining approximate 10% of the pancreas acts as an endocrine gland that consists of around a million pancreatic islets called the islets of Langerhans. Inside the islets are three main types of cell that detect the amount of glucose in the blood: alpha, beta and delta cells. Situated mostly around the outside of the cell are alpha cells, mainly towards the centre are beta cells, and scattered throughout in a limited number are delta cells. The pancreas secretes a number of hormones that help with the stasis of blood-glucose levels in humans including antagonistic hormones insulin and glucagon, as well as somatostatin. A hormone is a chemical messenger which is made in glands and carried around the body in the bloodstream to coordinate many body processes. Blood glucose homeostasis regulation is a form of negative feedback which is a self-correction mechanism of the body. This means that if an individual is hyperglycaemic, insulin output increases and glucagon output

The main function of the pancreas is maintaining blood glucose levels to about 70-150 milligrams per decilitre. The pancreas does this by measuring if the blood sugar level is too high or low, if it is not the correct level then a hormone is released. If the blood sugar level is too high insulin is released from the beta cells and causes glucose to enter body cells to be used for energy but sometimes can stimulate glucose to turn to glycogen in the liver. However, if it is too low then glucogen is released into the blood which causes the stored glycogen in the liver to break down

IDDM or Type 1 Diabetes is a condition of always-present hyperglycaemia, necessitating regular monitoring and insulin administration. In type 1 diabetes, the B cells or insulin makers are death, there is a zero insulin production and therefore, insulin administration becomes part of the everyday existence. What actually triggers destruction of B cells is malfunctioning of the immune system that over many years attacks and kills B cells. All of these processes will further trigger development