Diabetes is a disease where the body is unable to produce or use insulin effectively. Insulin is needed for proper storage and use of carbohydrates. Without it, blood sugar levels can become too high or too low, resulting in a diabetic emergency. It affects about 7.8% of the population. The incidence of diabetes is known to increase with age. It’s the leading cause of end-stage renal disease in the US, and is the primary cause of blindness and foot and leg amputation. It is known to cause neuropathy in up to 70% of diabetic patients. Individuals with diabetes are twice as likely to develop cardiovascular disease. There are two types of diabetes: Type 1 and Type 2.
Type 1 is characterized by the body’s inability to produce insulin. It is caused by autoimmune-mediated destruction of pancreatic beta cells, which are responsible for producing insulin. There appears to be a hereditary link in people with Type 1 diabetes. Other factors have been known to cause Type 1 diabetes such as viral infections, toxins, and other environmental factors. Type 1 diabetes is the rare form, affecting about 10% of the diabetes population. Its onset usually occurs in people less than the age of 20.
Type 2 is characterized by the body’s inability to use insulin effectively because of a combination of resistance to insulin as well as an overall decrease production in insulin. There is a genetic predisposition to Type 2 diabetes, but there are several other factors that also put an individual at
The objective of this chapter is to provide a well detailed systematic critical analysis of the chosen articles related to the research questions previously identified in chapter 1. This chapter has been divided into sub-sections to reflect the research questions of the literature review.
Uncontrolled diabetes can affect nearly every organ of the body; of which, heart disease and kidney failure are most commonly impacted. Known as diabetes mellitus, a collective term for various blood abnormalities, the term diabetes refers to either a scarcity of insulin in the body or the body’s inability to accept insulin. Though the symptoms of diabetes are manageable, many are unaware as to having it. According to the CDC report “2011 Diabetes Fact Sheet,” approximately 6 million people in the United States have undiagnosed diabetes. Undetected, diabetes can become deadly. In a recent World Health Organization report “Diabetes Action Now: An Initiative of the World Health Organization and the International Diabetes Federation,” it
Type 1 diabetes is an autoimmune disorder, in which the pancreas does not produce insulin. It usually begins in childhood or adolescence. In Type 1 diabetes, the body’s immune system destroys beta cells in the pancreas that produce insulin. Insulin is a hormone that converts sugar, starches, and food into energy. Without insulin, blood glucose levels become too high, which is known as hyperglycemia. To prevent hyperglycemia, people with Type 1 diabetes must take insulin daily to survive. Genetic and environmental factors affect the onset of Type 1 diabetes. [1] According to the American Diabetes Association, a predisposition to Type 1 diabetes is
Type 2 Diabetes is a disease that is found in a variety of age groups around the world. This disease is growing at a rapid rate and it is impacting the health of this generation and future generations to come. Diabetes is a disease that impairs the body’s ability to produce or respond to the insulin hormone produced by the pancreas. The insulin allows for the glucose to be effectively used as energy throughout the body. Diabetes causes carbohydrates to be abnormally digested, which can raise blood glucose levels. This means that the glucose is not being taken up by the cells that need it. The cells cannot take up the excess glucose that has accumulated in the blood, so it is excreted through the urine. This can lead to problems with the kidneys, central nervous system, heart, and eyes because high blood glucose can damage the blood vessels of these organs. This diseased is managed by adopting a diet low in fat and high in fiber, increasing physical activity, losing excess weight, and not smoking. If this
Diabetes mellitus is a group of metabolic disorders characterized by inadequate insulin secretion by the pancreas or cellular destruction leading to an insulin deficiency. Depending on the cause of the insulin shortage, diabetes can be subcategorized into type I and type II. Type I diabetes (T1DM) is usually mediated by the destruction of b-cells in the pancreas resulting in decreased insulin production and secretion. Type II diabetes (T2DM) is the failure of these b-cells to secrete adequate amounts of insulin to compensate for insulin resistance and increased gluconeogenesis combined with an overall resistance to the insulin action (8., 1997). T2DM accounts
Diabetes is a disease that affects the body’s ability to produce or use insulin. It is a precursor to numerous other diseases, which can quickly deteriorate patient’s health if
Type 2 diabetes is a very serious disease with many life threatening consequences, but if it is manage properly through preventative measures, diabetics can live a normal life.
Diabetes Type 2 1.Diabetes is considered a life style disease because it is not something you were born with it is something you bring upon yourself, stress, don't enough exercise, eating too much of the wrong foods, pregnancy or family history cause this particular disease. 2. Type 2 diabetes, or non-insulin-dependent diabetes, is the most common form of diabetes. It effects the respiratory system In Type 2 diabetes, either the body does not produce enough insulin or the cells neglect the insulin. Insulin is needed for the body to be able to use sugar.
Type 1: In type 1 diabetes the cells that produce insulin in the pancreas are destroyed and cannot be made, this type of diabetes usually occurs in childhood due to the autoimmune system attacking and destroying its own cells that produce the insulin, the beta cells in the islet of Langerhans are destroyed and thus unable to produce insulin. This type of diabetes in incurable and is treated with insulin injections.
Type 2 Diabetes Mellitus (T2DM) is the most common form of diabetes in the U.S., and it is a severe disease with numerous life-threatening consequences. T2DM occurs when insulin, which is a hormone released by the pancreas for sugar metabolism, becomes low or cannot be utilized by cells. In the normal condition, insulin circulates in the bloodstream and enables to convert starch, sugar, and all polysaccharides complex into glucose, which cells use for energy; however, in T2DM, there is continuously too much glucose in the bloodstream. When cells don’t interact appropriately with insulin, blood sugar increases, and this phenomenon is called insulin resistance that leads to many health problems,
Diabetes is a metabolic disorder in which energy cannot be obtained from the body through normal mechanisms of action. Insulin is required to assist in moving glucose across cell membranes. There are two types of diabetes. Type one, which is characterized by the pancreas no longer having the ability to make insulin, and Type two, which is characterized by the resistance of the tissue receptors of the body to insulin. Diabetes is sometimes called “The Silent Killer,” as it has significant rates of illness and mortality. There is a large correlation between diabetes and cardiovascular disease, end-stage renal disease, amputations, and blindness (Gulanick, Myers 2014).
As previously stated, there is Type 1 and Type 2 diabetes. Due to the differentiation, the etiology of diabetes is divergent. Being insulin-dependent, Type 1 diabetes is brought about by the immune system eradicating beta cells, leading to the deficiency of insulin. In contrast, Type 2 diabetes has a basis that can often times be prevented to an extent (“Causes of Diabetes”, 2014).
Type 1 Diabetes effects millions of people around the world (Michel & Montada-Atin, 2014). Most often, a person is diagnosed before their 30th birthday, with diagnosis commonly being between 11 and 13 years of age (Michel & Montada-Atin, 2014). Diabetes is a disease of the pancreas. More specifically, the breakdown of β cells in the pancreas causes the production of insulin to cease (Michel & Montada-Atin, 2014). Once the body is unable to
The genetics causes of Type I and Type II diabetes stem from elevated blood glucose levels. Type I diabetes is an autoimmune disease characterized by b -cell destruction, usually leading to an absolute insulin deficiency (Dahlquist 5). Type II diabetes extends from primarily insulin resistance with relative insulin deficiency to primarily defective insulin secretion with insulin resistance.
Diabetes is a systemic disease caused by a decrease in the secretion of insulin or reduced sensitivity or responsiveness to insulin by target tissue. (Beale, et al., 2011) The incidence of diabetes is growing rapidly in the United States and worldwide. An estimated 347 million people around the world are afflicted with diabetes. (Whalen, et al., 2012) According to World Health Organization (WHO), Diabetes prevalence among adults over 18 years of age has risen from 4.7% in 1980 to 8.5% in 2014. It is the major cause of blindness, kidney failure, heart attack, stroke and limbic amputation. World Health Organization (WHO) projects that diabetes will be the 7th leading cause of death in 2030. It is a complex and costly disease that can affect nearly every organ in the body and result in devastating consequences. The leading cause of non-traumatic lower extremity amputations, renal failure, and blindness in working-age adults, diabetes is also a major cause of premature mortality, stroke, cardiovascular disease, peripheral vascular disease, congenital malformations, perinatal mortality, and disability. (Cefalu, 2000) Insulin therapy and oral hypoglycemic agents have demonstrated improvement in glycaemic control. However, Insulin therapy has some disadvantages such as ineffectiveness following oral administration, short shelf life, of the need for constant refrigeration, and fatal hypoglycaemia, in the event of excess dosage.