The Effects of Genetic and Environmental Factors on Type 1 Diabetes
Type 1 diabetes is an autoimmune disorder, in which the pancreas does not produce insulin. It usually begins in childhood or adolescence. In Type 1 diabetes, the body’s immune system destroys beta cells in the pancreas that produce insulin. Insulin is a hormone that converts sugar, starches, and food into energy. Without insulin, blood glucose levels become too high, which is known as hyperglycemia. To prevent hyperglycemia, people with Type 1 diabetes must take insulin daily to survive. Genetic and environmental factors affect the onset of Type 1 diabetes. [1] According to the American Diabetes Association, a predisposition to Type 1 diabetes is
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The research on the affect of viruses in triggering Type 1 diabetes is inconclusive, and some is even contradictory. Some researchers have also found that viruses may prevent Type 1 diabetes. Scientists at Joslin Diabetes Center add trauma as a potential trigger of Type 1 diabetes. A traumatic event, such as a body trauma or a car crash, increases the body’s insulin requirement and strains the pancreas. [5] Dr. James H. Warram at the Joslin Diabetes Center concluded that the trauma does not cause diabetes, but it can trigger the onset of the disease.
Another possible environmental cause of Type 1 diabetes is early diet. Breastfeeding for at least three months has shown to decrease the risk of Type 1 diabetes, and a diet including cow’s milk before the age of one year old may increase the risk of diabetes. The American Diabetes Association reports that the onset of Type 1 diabetes occurs more often in winter than in summer. It is also more prevalent in cold climates. This leads researchers to conclude that cold weather may be a possible trigger of Type 1 diabetes, as well. [6] Dr. Andrew Weil (2014) explains that in addition, “Weather has an impact on eating and exercise habits, which can in turn influence how well you’re able to control your blood sugar.” (drweil.com, 2014) The phenotype for Type 1 diabetes includes the presence of autoantibodies in the body. [7] These autoantibodies prevent the pancreas from adequately
Type 1 diabetes is well known disease, some of us or someone we know are the victim of this chronic illness. There are controversial explanation such as, genetic susceptibility and in contrary, environmental factors that are viral infection, prenatal and neonatal influence, nitrate in drinking water, (Norris et al, 2003) early exposure to cow’s milk towards why the immune system destroy the insulin producing beta cell. In this essay, I will be discussing about the pathophysiology of type 1 diabetes and how it affect the homeostasis of our normal functioning body. In subject to Carol, I will be explaining the signs and symptoms of the illness and also the possible effects to her developing foetus and herself.
In type 1 is risks will mostly be if it’s genetically. In the family, if anyone that has type 1 diabetes it could be a parent or sibling. Genetics, when checked through clinical trials to see if someone who has a family history of the type. Geography, people living in different places might be affected with diabetes more than someone living in London. Viral experience may trigger the virus if the cells are infected. Low vitamin D levels, like when early drinking of cow’s milk because that’s the common foundation of vitamin D. Other dietary factors like
Type 1 Diabetes effects millions of people around the world (Michel & Montada-Atin, 2014). Most often, a person is diagnosed before their 30th birthday, with diagnosis commonly being between 11 and 13 years of age (Michel & Montada-Atin, 2014). Diabetes is a disease of the pancreas. More specifically, the breakdown of β cells in the pancreas causes the production of insulin to cease (Michel & Montada-Atin, 2014). Once the body is unable to
Type 1 is characterized by the body’s inability to produce insulin. It is caused by autoimmune-mediated destruction of pancreatic beta cells, which are responsible for producing insulin. There appears to be a hereditary link in people with Type 1 diabetes. Other factors have been known to cause Type 1 diabetes such as viral infections, toxins, and other environmental factors. Type 1 diabetes is the rare form, affecting about 10% of the diabetes population. Its onset usually occurs in people less than the age of 20.
"The facts are clear: The diabetes epidemic sweeping the U.S. is hitting the African American community particularly hard, according to doctors." (2) Diabetes is defined as, "A disease that affects the body's ability to produce or respond to insulin, a hormone that allows blood glucose (blood sugar) to enter the cells of the body and be used for energy." (1) There are two types of diabetes: type 1 diabetes and type 2 diabetes. Type 1 diabetes, which usually begins during childhood or adolescence, "Is a condition characterized by high blood glucose levels caused by total lack of insulin. This occurs when the body's immune system attacks the insulin producing beta cells in the pancreas
Diabetes type 1 develops when the immune system attacks the only cells that create insulin, the pancreatic beta cells. Due to the cells being destroyed, the person with diabetes type 1 has to be
Another theory on the cause of type one diabetes is environmental factors. Researchers have found that combined with genetic factors, exposure to certain environmental influences, such as climate, may increase the risk of developing T1D. However, there is no definite link between environmental factors and the diagnosis of type one
Type 1 diabetes forms when the insulin forming cells in the pancreas are destroyed. Normally, the glucose you obtain from your food stimulates the pancreas to release insulin into into the blood. This insulin is used to help secrete and transport the glucose molecules
Type 1 diabetes, also referred to as Insulin Dependent Diabetes Mellitus (IDDM) or Juvenile Diabetes, can be caused by a genetic disorder. It can occur at any age, but it is most often diagnosed in children, adolescents, or young adults around 20 years old or before a person is 30 years of age. Insulin is a hormone produced by special cells, called the beta cells, in the pancreas, an organ located in the area behind the stomach. Insulin is needed to move blood sugar (glucose) into cells, where it is stored and later used for energy. In type 1 diabetes, these cells produce little or no insulin. Without enough insulin, glucose builds up in the bloodstream instead of going into the cells. The body is unable to
Another trigger studies have shown is it is related to cold weather. Type 1 diabetes develops more often in winter than summer and is more common in places with cold climates. Another trigger might be viruses. Perhaps a virus that has only mild effects on most people triggers type 1 diabetes in others. Another affect could be early diet plans. Type 1 diabetes is less common in people who were breastfed and in those who first ate solid foods at later ages. The development of type 1 diabetes takes years to develop and researchers found that most of those who later got diabetes had certain autoantibodies in their blood for years before. Type 2 diabetes is a little different than type one on how it is more tied to your family history but it also depends on your environment. If you have a family history of type 2 diabetes, it may be difficult to figure out whether your diabetes is due to lifestyle factors like the environment or if it is genetic. Usually both are the case. But type 2 diabetes can be stopped or delayed by eating healthy foods and exercising to stay in good
As previously stated, there is Type 1 and Type 2 diabetes. Due to the differentiation, the etiology of diabetes is divergent. Being insulin-dependent, Type 1 diabetes is brought about by the immune system eradicating beta cells, leading to the deficiency of insulin. In contrast, Type 2 diabetes has a basis that can often times be prevented to an extent (“Causes of Diabetes”, 2014).
Type 1 diabetes occurs as a result of the body’s immune system attacking the insulin
Another cause is viruses. Type 1 diabetes often strikes shortly after a viral infection. The viruses that cause this are mumps, German measles, and a close relative of the virus that causes polio. Another cause is chemicals and drugs. Studies show that ingestion of pyrinimil, a poison used to kill rats, can trigger type 1 diabetes. So can the prescription drug pentamidine, used to treat pneumonia. The last cause is cows milk. Cows milk contains a protein similar to a protein found on beta cells. Exposure to cows milk during infancy may increase the risk of type 1 diabetes (Diabetes Research Institute).
Type 1 Diabetes Mellitus is an autoimmune dysfunction that usually occurs in the younger age group. This process involves the destruction of the beta cells which produce insulin in the body therefore making this dysfunction an
Type 1 diabetes is an autoimmune disease caused by the failure of the pancreas to produce insulin for the body, known as “pancreatic β-cell destruction” (Daneman 847). Also, the bodies of individuals with type 1 diabetes cannot release natural bodily sugars when blood sugar levels fall (Tkacs 36). Individuals who are most at risk for this disease are those who have a family history of the disease (Daneman 848). Also, individuals who have prior thyroid conditions are also susceptible to type 1 diabetes (Denvendra et al. 750). It is also thought possible, that specific viruses and the early eating habits of children can increase the risk of type 1 diabetes. This disease can occur in