Protocol
Patients were randomized in block size of four as follows:
►TG: 16 patients received 1 gm of taurine capsule (Now Foods, USA) twice daily in addition to maximum tolerated doses of guideline directed medical therapy [ACE-I or ARBs, BBs, Loop Diuretics and MRAs] for two months.
►CG: 18 patients received only maximum tolerated doses of guideline directed medical therapy for two months.
At baseline patients underwent full clinical and laboratory assessment. A thorough patient history was taken. Assessment of functional capacity and degree of Dyspnea was done according to “NYHA class”. The Quality of life was evaluated by using the Minnesota Living with Heart Failure Questionnaire (MLHFQ). A 2 ml blood sample was obtained for
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Categorical data were summarized as percentages (%) or number (n). Comparison between groups was done using the unpaired t-test or Mann-Whitney test as appropriate. Comparison within each group (baseline versus after two months) was done using the Wilcoxon signed rank test. Chi-Square test or Fisher's exact test were used for categorical variables. Percent change was calculated as follows:
[(current value – baseline value )/(baseline value)]x 100
Statistical significance was considered for p-value < 0.05.
Results:
From September 2014 to October 2015, a total of 94 patients admitted to CR unit were assessed for eligibility. 60 Patients fulfilled the criteria and 42 patients accepted to participate in the study with only 34 patients who continued to the end of the study.
At Baseline the two groups were comparable in all variables except for LVESV, patients in the CG had significantly higher LVESV values (p = 0.03), (table 1). Both groups were comparable for the medications administered except that the CG had higher number of patients receiving nitrates (p = 0.01), (table 2).
NT-proBNP
There was a significant decline in NT-proBNP levels after two months in both the TG (from 216.4 [89.4 - 363.2] to 120.1 [36.7 - 307.7], p=0.009) and CG (from 352.7 [130.9 - 601.9] to 208.82 [112.1 - 374.4], p=0.002). However, when comparing the percent change of NT-proBNP between the two groups, there was no significant
In the role of a supplementary prescriber I could review him weekly and gradually increase his dose in line with the CMP dose schedule, his symptoms and tolerance. BNF (2014) additionally supports this by recommending the need for a re-assessment including physical health checks when a patient has reached a certain dose before titrating
100-word summary of your patient’s medical diagnosis, care, prognosis, and nutrition needs. USM students MUST submit a copy of their actual chart note and NCP form for this patient in NFS 567L.
Heart failure affects nearly 6 million Americans. It is the leading cause of hospitalization in people older than 65. Roughly 550,000 people are diagnosed with heart failure each year (Emory Healthcare, 2014). Heart failure is a pathologic state where the heart cannot pump enough blood to meet the demand of the body’s metabolic needs or when the ventricle’s ability to fill is impaired. It is not a disease, but rather a complex clinical syndrome. The symptoms of heart failure come from pulmonary vascular congestion and inadequate perfusion of the systemic circulation. Individuals experience orthopnea,
The diagnosis is made when an ejection fraction of less than 40% is found during an echocardiogram test. Patients with known systolic heart failure and current or prior symptoms are Stage C. Most common symptoms include, shortness of breath, fatigue and reduced ability to exercise. Stage D is patients with systolic heart failure and presence of advanced symptoms after receiving optimum medical care. Other risk factors for heart failure are some diabetes medications, sleep apnea, congenital heart defects, viruses, and irregular heartbeats. Heart Failure can be treated and managed but not cured. It is a chronic condition.
The first step in the analysis was to categorize each patient by whether or not they passed the clinical threshold during their treatment and if their change was reliable. Clinical cutoff scores and Reliable Change Indexes (RCI) for the PHQ-9 and GAD-7 were obtained from past research [@Delgadillo2012; @Griffiths2015; @Kroenke2001; @Spitzer2006]. Clinical cutoff scores for the BASE-6 were obtained from unpublished pilot research and corresponded to the clinical cutoff of the commonly used OQ-45 measure.
Patients can choose between a once-daily oral dosage form and a more reliable once-monthly injectable dosage form.
For the collection of data, developed and verified NI surveillance was used. The NI surveillance was useful for measuring both the incidence and risk factors of VAP according to Katherason et al (2009). Demographical data, past medical history, medications, nutritional status, laboratory results, diagnosis, history of illness, etc were all included in the surveillance. The Acute Physiology and Chronic Health Evaluation III score measured the severity of the illness. The APCHE is comprised of the acute physiological score that entails the major physiological systems and the chronic health evaluation that incorporates the influence of co-morbid conditions on the patient’s current health (O'Keefe-McCarthy, Santiago, & Lau, 2008).
The results of main affects for assigned clients in the control group: gender (F(1,1.935) = 0.015, p = .907, η2 = .051), age
Therapeutic measures for a patient with congestive heart failure would be daily weights, dietary sodium restrictions, positioning in high or semi-Fowler’s position, frequent vital signs, oxygen by cannula or mask, medical devices: pacemakers, internal cardiac defibrillator, biventricular cardiac pacemaker, ventricular assist device, medications: digoxin, diuretics, inotropes, nesiritide, beta blockers, surgery: heart valve repair or replacement, coronary
The trial involved four different treatment levels, and patients were encouraged to enter the next level of treatment if they failed to achieve remission or response (50% reduction in symptoms) after a specified number of
| Based on explicit knowledge and this can be easy and fast to capture and analyse.Results can be generalised to larger populationsCan be repeated – therefore good test re-test reliability and validityStatistical analyses and interpretation are
The IDEAL study was a multi-centered, prospective, randomized, open-label, blinded endpoint classification trial (PROBE design).1,3 The study was conducted at 190 ambulatory care, and private specialist centers in Denmark, Finland, Iceland, the Netherlands, Norway, and Sweden.1,3 Recruitment and randomization was conducted from March 1999 to March 2001 and patients were followed up until March 2005.1,3 The objective of the IDEAL
Switching from immediate to prolonged release tacrolimus had an impact on between-patient variability of tacrolimus exposure in this cohort of patients. Although tacrolimus exposure (AUC0-24) tended to have less between patient variability, it was not statistically significant. The between-patient coefficients of variation (CV%) of dose-normalized Cmax, AUC0-24 and C0 for twice-daily tacrolimus (TD-Tac) were 56.8%, 66.8% and 78. 5%, respectively. Whereas, the between-patient coefficient of variation (CV%) of Cmax, AUC0-24 and C0 for Advagraf® (OD-Tac) were 48.1%, 57.3% and 65.0%, respectively (Table 7). Figure 21 and Figure 22 displayed the plot of Test for Equal Variances for dose-normalized AUC0-24 (µg*h/L/ mg/kg) and dose-normalized Cmax
Patient population was divided into two groups that included NT-pro-BNP level of more than 525 pg/mL (Group1) and NT-pro-BNP less than or equal to 525 pg/mL (Group2). These cutoff points were decided based on the NT-pro-BNP median. Descriptive statistics for the continuous variables were reported as mean ± standard deviation while categorical variables were summarized as frequencies and percentages. Chi square test was used to measure the association of the primary and secondary outcomes with NT-Pro-BNP. The level of statistical significance was set at a p < 0.05. All the statistical analysis on the data was done using SAS software package version 9.4 (SAS Institute Inc., NC, USA).
Concerning the administered basic therapy, all patients received MTX dose 17.5 mg/week. In addition, patients received hydroxychloroquine