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Effects Of Rotenone

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Rotenone is the most intoxicating member of the rotenoid family and is typically found in tropical plants. It is both an herbicide and insecticide having a half-life of 3-5 days depending on light conditions and degrade quickly in soil and water (Hisata 2002). The toxicity of rotenone comes from its high lipophilia and it can easily cross the blood brain barrier. It is mainly used in rats since, so far, the studies attempting to lesion in mice or monkeys have not been successful (Ferrante et al. 1997; Thiffault et al. 2000). Recently, some studies have tested the toxicity of rotenone when administrated intragastric (Pan-Montojo et al. 2010) or directly in the brain (Alam et al. 2004).
The administration of rotenone can be done via different

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