Essay On Cervical Dysplasia

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CIN (formerly cervical dysplasia) refers to premalignant changes in the cervical epithelium that have the potential to progress to cervical cancer. The histologic features most commonly associated with cervical dysplasia include cellular immaturity, cellular disorganization, nuclear abnormalities, and increased mitotic activity. The severity of CIN is de termined by the portion of epithelium showing disordered growth and development. The changes start at the basal layer of the epithelium and can expand to encompass the entire epithelium .Cervical intraepithelial neoplasia (CIN), formerly called dysplasia, means disordered growth and development of the epithelial lining of the cervix. There are various degrees of CIN. Mild dysplasia, or CIN I, is defined as disordered growth of the lower third of the epithelial lining. Abnormal maturation of the lower two-thirds of the lining is called moderate dysplasia, or …show more content…

Severe dysplasia, CIN III, encompasses more than two-thirds of the epithelial thickness with carcinoma in situ (CIS) representing full-thickness dysmaturity. While histologically evaluated lesions are characterized using the CIN nomenclature, cytologic smears are classified according to the Bethesda system, which was most recently revised in 2001. Briefly, atypical squamous cells are divided into those of undetermined significance (ASC-US) and those in which a high grade lesion cannot be excluded (ASC-H). Low-grade squamous intraepithelial lesion (LSIL) encompasses cytologic changes consistent with koilocytic atypia or CIN I. High-grade squamous intraepithelial lesion (HSIL) denotes the cytologic findings corresponding to CIN II and CIN III. CIN may be suspected because of an abnormal cytologic

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