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Essay On Dosage Form

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For many disease states, successful drug therapy depends not only on the choice of an appropriate drug, but also on the choice of suitable formulation. The task of the research and development scientist involved in the formulation of a new product is to develop a dosage form which is optimum from both the technical and biopharmaceutical stand point. The majority of the drugs are formulated into dosage form which deliver the drug to the general circulation at a rate which is controlled by the physiological process in the body and not controlled by the dosage forms themselves. However, for many diseases the selected drugs should be delivered from the dosage form in the required amount at a constant rate to the target organ over the desired …show more content…

However, continuous administration of the drugs by conventional drug delivery systems is either impossible or impractical.
These limitations coupled with the findings that the rate of absorption into the body can be controlled by controlling the rate of release of drugs from the dosage forms, have led to the development of more practical and highly promising methods which can provide the required blood level of drugs for the desired period of time. One such approach is sustained release drug delivery system, which allows an initial release of drug sufficient to provide a therapeutic dose soon after administration and then a gradual release over an extended period of time.
Polymers have become an integral part of pharmaceutical formulations because of their ability to provide controlled release of therapeutic agents at constant doses over extended time periods (1). Both natural and synthetic polymers have been extensively used for this purpose (2). In recent years, the natural polymers have witnessed increasing attention for controlled drug delivery due to their excellent biocompatibility, biodegradability, low cytotoxicity, ease of chemical modifications, and abundance in the nature (3-5). However, the selection of appropriate polymer or polymer blends for a particular formulation depends on where and how the drugs are intended to be released. In this review, we highlight the various natural polymers used in controlled delivery of oral therapeutics, their advantages

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