My research focuses on medical imaging and image processing to understand structure and brain function of both healthy and diseased brain. Specifically, some of my interests and expertise include: 1) developing improved MRI relaxometry methods and their applications towards diseased brain, 2) investigating the relationship between brain structure and function and cognitive performance in both healthy and diseased brain such as multiple sclerosis (MS), 3) investigating the neurophysiological bases of brain white matter signals; 4) developing potential biomarker for multiple sclerosis using iron sensitive MRI measures.
Past Research: My PhD thesis combined the development of MRI methods and their applications to patients with MS. The main
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This work addressed means to overcome the tissue heating limitations to enable more rapid multi-slice T2 mapping. The tissue heating limitations were overcome by shortening the echo train lengths. Consistent T2 values were found with as few as 4 refocusing RF pulses compared to 20 refocusing RF pulses. RF power savings through the use of reduced number of RF pulses enabled increased slice coverage. That means, using the improved method, MRI scan time can be reduced by 5 times compared to the previous method. This T2 mapping approach is useful for obtaining accurate T2 values in grey matter and white matter in the brain. These findings were originally published in [1] and [2].
Second, evaluate the iron dynamics in MS using improved T2 mapping method using 26 age- and sex-matched healthy volunteers and patients with multiple sclerosis. Compared to controls, the MS patients had smaller deep grey matter volumes and increased iron content in these structures over two years, but significant changes were found one the deep grey matter structures. This finding indicates, combination of atrophy and T2 measurements in deep grey matter can be used as biomarkers to monitor disease progression and dynamics of iron accumulation in MS. This work has been published as a conference proceeding [3] and then as journal article [4].
Third, we compared the benefits and limitations of different MRI relaxometry (T2, T2*, T2’ and FDRI, relaxometry
Multiple sclerosis, also known as MS, is one of humankind’s most mysterious diseases. No one knows the exact cause and there is no exact treatment. Still multiple sclerosis has the ability to affect nearly 3 million people worldwide and at least 500,000 people in the United States (Boroch). This disease tends to be more common in individuals of northern European descent and women are more than twice as likely to develop multiple sclerosis as men. Of those 3 million people, most of them are between the ages of 20 and 50 years old (Dangond). Even though multiple sclerosis is a mystery disease, scientists are working to determine the exact cause and treatment.
Multiple Sclerosis affects 2.3 million people worldwide. Multiple Sclerosis patients diagnosed are in the age range of twenty to fifty. Multiple Sclerosis effects the myelin in the central nervous system that disrupts the flow of information that is sent to the brain. This disruption effects your vision, mobility and bodily functions. Multiple Sclerosis has a wide variety of people it can effect. Your age, sex, where you grew up and even certain infections like Mono. There are a few tests that can be done to find out if you have Multiple Sclerosis, such as; MRI (Magnetic Resonance Imaging) this is not the only test but it is a huge
Multiple Sclerosis (MS) is a neurologic disease that affects the Central Nervous System (CNS) through cellular immune response and the demyelination of CNS white matter (McCance et al., 2014, pp. 630–633). The initial causes of MS are unknown however, it is believed that it could possibly be due to an immune response to an initiating infection or an autoimmune response to CNS antigens on the myelin itself (Brück, 2005) (Miljković and Spasojević, 2013). MS is a result of the degradation of the myelin sheath surrounding neurons and therefore disrupts the transmission of action potentials along these cells. MS can display itself in the form of symptoms ranging from muscle weakness to trouble with sensation and coordination (NHS, 2016). The degradation of myelin leads the body to attempt to remyelinate the neurons, a process that in turn leads to the thickening of the cell by glial cells and this causes lesions to form (Chari, 2007). It is this thickening (sclerae) from which the disease gets its name. Sufferers of MS can either have a relapsing type of MS, in which there are episodes that lead to the worsening of symptoms for a period of time, or a progressive type of MS where symptoms gradually progress and worsen (McCance et al., 2014, pp. 630–633).
Multiple sclerosis, or MS, is a disease of the central nervous system. The central nervous system is made up of the brain and spinal cord. Both have nerve fibers that are wrapped in a myelin sheath. In MS, the myelin sheath becomes inflamed and gradually is destroyed. With the destruction of the myelin sheath comes an array of symptoms that may include numbness or tingling, balance problems, weakness, muscle spasms, and blurred vision.
All MR images were evaluated in T2WI and DWI for site, size, and signal intensity of the
Multiple sclerosis, or MS, is a disease of the central nervous system. The central nervous system is made up of the brain and spinal cord. Both have nerve fibers that are wrapped in a myelin sheath. In MS, the myelin sheath becomes inflamed and gradually is destroyed. With the destruction of the myelin sheath comes an array of symptoms that may include numbness or tingling, balance problems, weakness, muscle spasms, and blurred vision.
Multiple Sclerosis, commonly known as MS is an autoimmune disease of the central nervous system. Scientists have been studying MS since the 19th century. In MS, the body’s immune system produces cells and antibodies that attack myelin in your brain which is essential for the nerves in your brain and spinal cord to conduct electricity to perform its function. The attack on myelin results in vison loss, paralysis, numbness, muscle weakness, difficulty walking, stiffness, spasms, and bladder and bowel problems. MS has varying degrees of severity and affects people between the ages of 20-50, mostly women. Although there are treatments, there is no cause and cure yet.
Multiple Sclerosis is an inflammatory demyelinating neurodegenerative disorder of the central nervous system that has the potential to cause significant disability in those affected through the body's immune system attacking and destroying the myelin sheaths surrounding the axons. Myelin is rich in lipids and proteins that form layers around the nerve fibers and acts as insulation and protection. This damage to the myelin in the CNS, and to the actual nerve fibers, has the potential to block the transmission of nerve signals between the brain and spinal cord and also other parts of the body. This disruption of the nerve signals produces the primary symptoms of MS which then possibly lead to secondary and tertiary symptoms stemming from these
Multiple sclerosis (MS) is an autoimmune condition where the body attacks the myelin covering of its nerves and brain tissue. This results in inflammation and damage to these nervous system structures, resulting in disruption in nerve signals. These changes affect motor function, manifested as loss of balance and
Multiple sclerosis, also known as MS, is an autoimmune and inflammatory disease that is very painful for both the patient and care giver. In the disease, there is inflammation and neurodegeneration acting at the same time. There is currently no known primary cause of multiple sclerosis. The disease is however characterized by damaged fatty myelin sheaths around the axons of the brain and the spinal cord. Myelin is a mixture of proteins and phospholipids that protects many nerve fibers enabling speed at which impulses are conducted. It is pathologically characterized as the presence of glial scars all over in the central nervous system. The disease was discovered by the French neurologist Jean-Martin Charcot in 1868 when he examined the brain
Multiple sclerosis (MS) is an acquired demyelinating disease of the central nervous system (CNS) that typically is diagnosed in the second or third decade of life. Normally, nerves are enclosed in myelin sheaths that help facilitate transmission of nerve impulses within the CNS and the peripheral nervous system throughout the body. In patients with MS, the myelin sheath is damaged and eventually degenerates, causing patches of scar tissue called plaques or lesions to occur anywhere randomly on the myelin sheath (Ruto, 2013). This results in impaired nerve conductivity, which interferes with message transmission between the brain and the other parts of the body. As a result, impulse transmission is altered, distorted, short-circuited, or completely absent. This interference in impulse transmission creates muscle weakness, muscle imbalance, and possibly muscle spasms with partial or complete paralysis. Multiple sclerosis also can result in visual impairment and alteration of cognitive abilities, as well as pain, numbness, or tingling sensations (Ruto, 2013).
Multiple Sclerosis is a chronic autoimmune disease that attacks a person Central Nervous System which includes the spinal cord, brain and optic nerves. MS is a very difficult condition to diagnose due to its exacerbations. It also is difficult to treat because no one person has the same signs and symptoms. In MS the myelin sheath that protects the CNS becomes inflamed and scarred that end up causing lesions.. The lesions cause interruption in the messages to the nerves. MS can happen at any age but mostly found in ages 15-60 and are twice as likely in women. Currently there is no known cure for MS , researchers are working tirelessly to find one.
Multiple sclerosis (MS) is a very complex disease characterized by many different pathophysiological mechanisms that play a role in how the disease presents itself and its progression (Miller, 2012). Some mechanisms that play a role in MS are demyelination, axonal/neuronal damage, inflammation, gliosis, etc (Miller, 2012). Among 20-40 year olds, MS is the most common neurological disease (Miller, 2012). There are many different causes associated with MS but the two main causes of MS are axonal injury and oxidative stress and excitotoxicity.
The new discoveries, quality improvements, and evidence-based care that has changed the course of multiple sclerosis diagnosis, treatment, and care since Jean Martin Charcot and Florence Nightingale’s time is encouraging and exciting for those that live with the disease. New technologies and critical milestones abound. For example, in 1981 the first MRI pictures of a brain affected by MS was produced ("Research News and Progress," 2016). Also, magnetic resonance imaging (MRI) has been instrumental in allowing more precise diagnosis and important biomarkers for determining the effect of treatments from clinical trials (Koutsouraki & Michmizos, 2014). These remarkable advances in
The MRI has made a great impact in many areas of modern medicine, it has become an important piece of technology in medical practice and research. With the ultrafast imaging, images of the areas of interest can be obtained quickly with the elimination of psychological motion artifacts. Magnetic Resonance removes the need