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Essay On Image Processing

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My research focuses on medical imaging and image processing to understand structure and brain function of both healthy and diseased brain. Specifically, some of my interests and expertise include: 1) developing improved MRI relaxometry methods and their applications towards diseased brain, 2) investigating the relationship between brain structure and function and cognitive performance in both healthy and diseased brain such as multiple sclerosis (MS), 3) investigating the neurophysiological bases of brain white matter signals; 4) developing potential biomarker for multiple sclerosis using iron sensitive MRI measures.

Past Research: My PhD thesis combined the development of MRI methods and their applications to patients with MS. The main …show more content…

This work addressed means to overcome the tissue heating limitations to enable more rapid multi-slice T2 mapping. The tissue heating limitations were overcome by shortening the echo train lengths. Consistent T2 values were found with as few as 4 refocusing RF pulses compared to 20 refocusing RF pulses. RF power savings through the use of reduced number of RF pulses enabled increased slice coverage. That means, using the improved method, MRI scan time can be reduced by 5 times compared to the previous method. This T2 mapping approach is useful for obtaining accurate T2 values in grey matter and white matter in the brain. These findings were originally published in [1] and [2].

Second, evaluate the iron dynamics in MS using improved T2 mapping method using 26 age- and sex-matched healthy volunteers and patients with multiple sclerosis. Compared to controls, the MS patients had smaller deep grey matter volumes and increased iron content in these structures over two years, but significant changes were found one the deep grey matter structures. This finding indicates, combination of atrophy and T2 measurements in deep grey matter can be used as biomarkers to monitor disease progression and dynamics of iron accumulation in MS. This work has been published as a conference proceeding [3] and then as journal article [4].

Third, we compared the benefits and limitations of different MRI relaxometry (T2, T2*, T2’ and FDRI, relaxometry

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