Is There a ‘Single’ Vaccine for the Influenza Virus
Introduction/ Background The human immune system is constantly undergoing changes because of the pathogens that are trying to invade the body. Once the pathogens cross your initial barriers your body has a second defence that comes into play. This is your immune system which is composed of your innate and adaptive immunity. Innate immunity has two line of defense, the first line starting with the skin and mucosal membranes, these create barrier to try and fight off pathogens entering the body. The second line is an internal response consisting of many types of phagocytes, and chemicals and physiological processes which fight against pathogens (pg 854 Textbook). Meanwhile adaptive immunity is a response that has multiple cells that work to fight off specific pathogens. These cells start off as simple T-lymphocytes and B-lymphocytes. T-lymphocytes go through a process when identifying a pathogen and eventually form cytotoxic T- lymphocytes and helper T-lymphocytes. When B- lymphocytes cross a pathogen they form into plasma cells in order to release antibodies and target (textbook pg 864). These two immunities play a big role in providing a healthy defense after vaccination is injected to allow the body to be immuned to
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Before beginning research on this topic we did not understand that it was just the hemagglutinin head that mutates. It was interesting finding out that the stalk/stem of the virus stays the same and could lead to creating a universal vaccine which could be given once. As of right now there isn't a vaccine which we can get to help protect us for a lifetime against the influenza virus. Hopefully within the next few years Dr. Schrader and his team will be able to come up with a single shot
In the early 1900’s medicine was making some steps closer into some great improvements for health and better understanding of the human body. Doctors with sufficient knowledge of the human body and cures for diseases and viruses were scarce. People were much more concerned with government and politics, than health and medicine, until one of the greatest and most grotesque lethal pandemics that’s struck the earth in human history. This pandemic the “Spanish Flu” spread so rapidly and had an extremely high mortality rate. This was caused by the close contact of humans and poor cleanliness and sanitation, and the host (virus) and the body taking harsh action
Yes. On a various type of surfaces Influenza, A and B can survive for 24-48 hours (Bean, Moore,
According to the CDC there was a breakout in “1918-19 Flu pandemic, which killed as many as 50 million people worldwide”causing the biggest breakout for Influenza (Reconstruction of 1918 Influenza Pandemic Virus). Influenza originated from Asia and the Middle East. Virtually all mammalian species have influenza. Influenza is a contagious respiratory illness caused by the Influenza virus. There are three types of Influenza: type A, type B, and type C. Influenza has numerous symptoms, vaccinations, and is unlikely to kill it’s host.
Walking down any given street in the year 1918 between the months of June and December, one would take notice of coffins lining the sidewalks. Nobody was on the streets, and dead bodies were stuffed into every available space. The Flu Epidemic of 1918 not only was the most devastating event of the twentieth century, but propelled the United States to search for a vaccine that has not yet been found, causing concern that the flu will strike again.
Describe two innate (nonspecific) immune responses that might prevent an influenza virus from causing any noticeable infection, even if the virus enters your respiratory passages.
For the past ten years, we at Virginia Mason Medical Center have been implementing mandatory influenza vaccination. This is due to the flu vaccination being able to reduce flu illnesses and prevent flu-related hospitalizations. According to the Center for Control and Disease (CDC, 2014) during 2012-2013, an estimated 45% of the U.S population got vaccinated, helping to prevent an estimated 6.6 million flu-related illness, with 3.2 million flu-related medical visits, almost 80,000 hospitalizations and roughly $87 billion dollars in total economic burden. Influenza is extremely contagious and each year on an average 5%-20% of the U.S population get the flu with tens of thousands die from a flu-related illness. Therefore, many health cares setting along with Virginia Mason Medical Center is mandating all their healthcare workers to get the influenza vaccination. Consequently, making annual influenza vaccination requirement for healthcare workers a continuing and debatable health topic. The potential of getting the vaccination have great benefits to healthcare professionals, their patients, and their families by
“It killed more people in twenty-four weeks than AIDS has killed in twenty-four years, more in a year than the Black Death killed in a century. – John Barry
This research paper covers the basic history of influenza. It begins with its early history
It seems like everywhere you go you are reminded that it is that time of the year. Just a short drive around town it is evident that flu shots are encouraged everywhere one looks. From medical personnel to store checkouts one finds themselve bombarded with the question, “Have you gotten your flu shot yet?” Anyone and everyone is a candidate for the flu vaccine according to local pharmacies. (and many people are buying into this mantra).
Illnesses have long haunted the human race. As long as these illnesses have existed, humans have developed ways to cure themselves, beginning with simple herbs and proceeding as far as vaccines and complex medicines. One cure that long eluded scientists was that of the influenza virus. Now, the influenza vaccine, or flu shot, saves thousands of lives a year and helps prevent serious complications resulting from influenza infection.
CDC reports released earlier this year revealed that only 40% of the American population was vaccinated against the Influenza Virus (IFV), last year. The vaccines are expected to reduce need for treatment from healthcare providers by 60% and yet the majority of the population remains vulnerable to this rapidly, mutating virus. (Brandenburg et al., 2013)
Influenza viruses are divided into three classes. These are A, B, and C. Influenza A and B are blamed for the increases in hospitalization and deaths each year. The aim of receiving an annual vaccine is to prevent spreading infections. Since flu outbreaks vary, it is recommended that individuals receive a vaccination for the flu
Whilst this is occurring, memory B cells figure out the shape of the antigen and remember it. This allows the B cells to produce antibodies much faster if the pathogen reinfects the person. The problem with the human immune system is that it takes approximately three weeks to reach peak antibody concentration and remove all of the pathogens in the body. Many pathogenic diseases (tetanus, polio, meningococcal etc) will kill the individual before the 3rd line of defence has the chance to destroy them. Vaccination involves injecting antigens (in the form of attenuated pathogens or pathogen parts) into the body. This causes the same immune response that would occur if the individual was infected with the actual disease; however, because the pathogens have been weakened (or killed) and had their reproductive ability inhibited, they cannot kill. This means that If the individual is infected by the pathogen in the future, he/she is extremely unlikely to get the disease (RNA based viruses such as Influenza are exempt from this due to their antigenic shift/drift ability). The use of repeated vaccination (eg. vaccination for a particular disease at two, four and six years of age) enhances the immune system even more.
Our immune system is made up of two parts that work together to keep us healthy. The first part is called the innate immune system, it is made up mostly of ‘scavenger’ and ‘killer’ cells that fight off bacterial infections and give the body a general defense against harmful substances. The second part of the immune system is called the adaptive immune system. This part
There are non-pharmacological management options which people believe are effective at helping alleviate the symptoms of the flu. For instance, gargling with warm water, honey and lemon is believed to help manage sore throats and alleviate dry, irritating coughs, similarly to how steam inhalation is believed to alleviate nasal congestion or a stuffy nose (Communicable Disease Control and Prevention, 2017).