Etoricoxib a Non-steroidal Anti-inflammatory Drug Used in Beachdale Surgery

More than 6.1 million people in Australia suffer from arthritis. Arthritis is a disease characterized by pain, swelling and stiffness in the joints. There are more than 100 types of disease which is one of the most chronic in the world. It impacts on a person’s basic daily tasks causing joint weakness, uncertainty, and distortion. It affects community, both economic and personal resulting the need for more hospitals and primary health care services. The number of people with arthritis is higher at old ages, however there are more people who are suffering from this disease are between 35 to 64 years group. Arthritis is not yet curable and treatments vary depending on the type of arthritis. To

Anne is currently taking paracetamol for the pain in her wrist, within healthcare analgesia should always be monitored to assess whether it is achieving elimination of pain and should be adapted to the individual patient (Vargas-Schaffer, 2010). If paracetamol were not effective in eliminating Anne’s pain then practitioners should consider a non-steroidal anti-inflammatory medication [NSAIDS] or a mild opioid medication such as codeine as the next step (Vargas-Schaffer, 2010). However as Anne is asthmatic NSAID medication should be used with caution due to the risk of increased frequency of asthma attacks and breathlessness (Joint Formulary Committee, 2015); if Anne has taken NSAIDS before with no issue then this would be the next choice of analgesia followed by codeine if combined paracetamol and NSAID did not prove effective (Vargas-Schaffer,

Are there any contraindications for this drug? Hypersensitivity, cross-sensitivity with other NSAID’s such as aspirin, history of allergic reactions, asthma, advanced renal disease, hepatic dysfunctions, perioperative pain.

In the next several months we should have the new Cox-2 inhibitor drugs available. These are hopefully going to be much less irritating to the stomach as they don't inhibit the prostaglandins

The type of treatment chosen depends on the type of arthritis and the effects it has on the patient as well as the severity of the disease. Other factors to consider are the age of the patient and the joints affected. Bearing in mind that different people exhibit different reactions to different medications, treatment in this case is individualized but includes a combination of joint protection methods and medication. For rheumatoid arthritis, the Initial treatment starts with non steroidal ant inflammatory drugs and other simple analgesic but as the inflammation progresses, slow acting anti rheumatoid drugs which are aimed at modifying the disease are introduced. They are added progressively as the inflammation progresses in order to suppress the process that leads to chronic inflammation (Amin 1995).

When patients are prescribed to a medicine for low amounts of pain, they are usually prescribed daily use of anti-inflammatory pills such as ibuprofen or tylenol. For more severe pain, patients are often prescribed these pills in higher dosages, or even prescribed opiates such as vicodin or oxycontin (Meisel & Perrone). Anti-inflammatory pills are not as powerful as drugs such as opioids, but they present the risk of cardiovascular problems

Nonsteroidal anti-inflammatory drugs are a common class of analgesic typically used chronically for pain such as musculoskeletal pain including osteoarthritis. It is commonly used in the elderly population.

drugs prevent the synthesis of prostaglandins, an enzyme, which are the body’s defence to injury.

Non-steroidal anti-inflammatory drugs (NSAIDs) are the foundation of medical treatment for osteoarthritis (OA). It is the most common medication taken by an individual experiencing pain due to this degenerative joint disease. Not to mention, NSAIDS are prescribed for pain management in older adults since they are more efficacious than acetaminophen with the absence of central nervous system side effects of opioids

It is noted that Celebrex aids in reducing arthralgia and reduces frequency and severity of flare-ups. However, there is no documentation of why a non-selective Cox inhibitor is not appropriate for this patient. Furthermore, there is no documentation of increased risk for gastric complications or prior gastric conditions. Failure of first line NSAIDs was not described. Medical necessity of Celebrex has not been substantiated. Therefore, recommend

In only severe case do extreme symptoms present which are very rare. There is no complete cure to any of the condition however using Meloxicam can decrease pain as well as lessen the symptoms. Meloxicam is used to treat both of these conditions for an extended period of time, but osteoarthritis is treated (with Meloxicam) only on a short term bases. Osteoarthritis is a condition which almost everyone will eventually suffer from. Currently 8/10 people aged over 50 suffer, every joint can be effected as the cause of osteoarthritis is the extended use of the joints which causes the cartilage to become thin and uneven. The synovial fluid also becomes thicker and excess is also produced which cause the joint swell, bony spurs can also grow which also lead to further inflammation in the surrounding tissue. All of the conditions mentioned above have one similarity in that they all cause an inflammatory response. Meloxicam inhibits the production of prostaglandins which are the chemical messengers which stimulate an immune response and results in inflammation. It specifically inhibits the cyclo-oxygenase process which is the process in which prostaglandins are produced.

In one study, a randomized trial was conducted in which half of a group of arthritis patients were given 200 mg of Celebrex daily and half were given 1,200 mg of SAM-e joint health supplements daily over the course of 16 weeks. The study found that the Celebrex group showed far more pain reduction during the first month than the SAM-e group, but by the second month, both groups showed an equal and significant lessening of pain. The research concluded that although slower-acting, SAM-e joint health supplements are just as effective as Celebrex for osteoarthritis-related knee

COX or cyclo- oxygenase is a type of enzyme that is involved in the formation of prostaglandins. Prostaglandins is a nuisance to our body because it can cause a bunch of things like, inflammation, high body temperature, and pain. This is where the Aspirin come into action; it inhibits COX to prevent the formation of prostaglandins.

Medications that can cause interactions include anticoagulants, probenecid, bisphosphonates, angiotensin-converting enzyme (ACE) inhibitors, anticoagulants (Warfarin), antiplatelet medicines (Clopidogrel), aspirin, corticosteroids (Prednisone), heparin, other NSAIDs (Ibuprofen), Rivaroxaban, or Selective Serotonin Reuptake Inhibitors (SSRIs) (Fluoxetine) due to the risk of stomach bleeding may be increased. Bisphosphonates (Alendronate), Cyclosporine, Hydantoins (Phenytoin), Lithium, Methotrexate, Quinolones (Ciprofloxacin), Sulfonamides (Sulfamethoxazole), and Sulfonylureas (Glipizide) side effects may be increased by Naproxen. The effectiveness of Angiotensin-converting enzyme (ACE) inhibitors (Enalapril), Beta-blockers (Propranolol), or diuretics (Furosemide, Hydrochlorothiazide) may be decreased by Naproxen (Lexi-Comp,

In the United States, arthritis has become the second most common disorder, in the past years. Moreover, the condition affects more than 34 million Caucasians, 4.6 million African-Americans and nearly 3.1 million Hispanics with women being the most affected (Helmick, 2008). 28.3% of people suffering from arthritis are women whereas 18.2% are men (Helmick, 2008). By the year 2030, it is predicted that the number of patients with arthritis will double if prevalence rates remain the same. Apart from being cost-intensive, Osteoarthritis (OA) affects nearly twenty seven million Americans, which effectively limits their work (Reid, Shengelia & Parker, 2012). The statistics show that Caucasians are the most affected and the Hispanics to be the less affected from Caucasians, Hispanics, and African Americans. It also shows how women also have greater possibilities of getting arthritis than man ever did.