Seminar Talk Summary:
(a) In the seminar given to us by Damien Samways, we were exposed to the research and discoveries linked to transmembrane transport mechanisms for selective drug delivery, specifically leading into selective permeabilization of cervical cancer cells. We learned that the beginning of the research was based mainly on the ATP and calcium in cells and how they could be used or manipulated for transport and permeabilization used to get drugs into cells and were faced with the question if this could have a therapeutic effect. The research was soon focused onto the P2x and P2y receptors of the cell, which are ion channels activated by ATP. Further research on the receptors determined that ATP could permeabilize cells and some channels within the cells transport therapeutic drugs using a process called selective silencing. With this information, the curiosity arose for the use of anticancer drugs with and intracellular target, although this process had known problems. The concerns included getting the drug across the plasma membrane of the cells and the fact that they only wanted the drug to get into cancer cells, not all cells. In the lab model, fluorescent cytotoxins were used to determine the uptake into the cells. A hypothesis was then made the ATP can permeabilize cells to some small fluorescent cytotoxins. Focus was then placed on the P2y receptors and the original idea of ATP, which can be used to increase the permeability of cancer cells and
This Tedx talk was by Ron Espiritu, an educator of ethnic, Chicano and African American studies for high school students in south Los Angeles. He has found that ethnic studies is empowering, liberating and transformative for young people. Ron talks about researchers finding that ethnic studies has positive academic and social results for students of all races and ethnic backgrounds. He talks about his grandmother being forced to wear a sign on her chest saying she won't speak Spanish. I never knew that schools were against different languages to this extent. I thought it was acceptable to speak different languages, I was very wrong. Ron goes on to talk about his mother who used her mother as an inspiration. He talks about his mother becoming
In the Ted Talk, the presenter Daniel Reisel talks about how we can change both our society and mindset. Reisel demonstrates an example about prisoners in a high- security and it's filled with aggressive prisoners. He talks about what triggers that behavior that those prisoners have and what can be the cure for them. Reisel talks about the Joe the prisoner and how he tested Joe and his inmates to see their ability to categorize images of emotions. The inmates failed to show emotions and to show physical response for the images they were showed. It showed that the inmates had a deficit in their brain that was ¨amygdala” that was proven by their MRI scan. Amygdala is known for our experience of empathy in which the inmates did not have causing
Michelle Obama once said during her Velvet Glove Convention Speech, “We learned about honesty and integrity that the truth matters... that you don't take shortcuts or play by your own set of rules... and success doesn't count unless you earn it fair and square.” This quotation means that learning comes from honestly and integrity, speaking the truth is important in order to succeed in the future. This quotation relates to the Ted Talk speech How great leaders inspire action, by Simon Sinek because he explains how many companies such as Apple succeed with consumers buying there products through the method of the golden circle. Leaders who make an impact in society, companies, and many high officials that inspire us, Simon Sinek revealed there
These drugs were utilized in order to demonstrate the positive and negative effects on cell communication. Cell communication consists of three steps: reception, transduction, and response. Reception involves the binding of a ligand and a receptor; transduction is a “cascade” of actions between molecules and their proteins, and response is the change that occurs afterwards (1).
Tests are called "standardized" when all students answer the same questions under similar atmosphere and their answers are
I watched this TedTalk on 6/16/2016, and the name of that TedTalk is Uber’s plan to get more people into fewer cars. The video was filmed on February 2016, and the speaker is Travis Kalanick, the co-founder of the peer-to-peer file sharing company Red Swoosh and the transportation network company Uber. The purpose of this memo is to understand the goal that Uber is trying to achieve.
24.Which of the following are common means by which binding of an intercellular chemical messenger with a cell’s receptor brings about an intracellular response?
In choosing to select a topic from Healthy People 2020, the writer met with Sheila Dobbins, FNP and AIM Administrator for Sutter Care at Home. With the population serviced by Sutter Care at Home, it was decided that the topic of older adults would benefit the staff. The presentation would be a PowerPoint presentation followed by a game for interaction with the staff. Ms. Dobbins also expressed interest in community resources for the staff to be able to provide to their patients and families. Estimated time for the presentation would be twenty-five minutes including questions and time for the game. The location would be at Sutter Care at Home conference room located in Modesto, California on January 3, 2017. The participants would include nurses, physical therapy, medical social worker, and administrator. Due to improved technology, medical care, and medications people in the US are living longer. The quality of life needs to be taken into consideration and education provided to the aging person and families for disease prevention. Education provided to those aging on preventive measures to prevent chronic disease will reduce the financial burden on the economy as well as improve the quality of life for the person.
In the Ted Talk video, "Want to help someone? Shut up and listen", Ernesto Slurry does an excellent job in explaining the three fundamental criteria’s that should be used by any sale person. He states that for a wise sale person he should apply the Ask, Shut Up and Listen to approach. The ask statement is used to engage a prospect into a conversation. A question is asked to makes the prospect answer the question. The sales person is supposed to listen to the response offered by the candidate. According to Ernesto, the journey does not only start at asking the question and the listening to the answer but in between there exist a sage of shutting up. The shut-up stage is relevant as it is the stage where the prospect is thinking about what to
In his February 2013 Ted talk “Txtng is killing language. JK!!!,” the linguist John McWhorter argues against the notion that texting leads to the downfall of literacy among the younger generation. In fact, the speaker claims that texting causes the development of the “linguistic repertoire” and the formation of a new language. In order to do so, McWhorter acknowledges the status quo of the perception of texting among the older generation; texting is the “scourge” that leads to the “decline of the writing ability” of the younger generation. In response to the status quo, according to McWhorter, texting creates an “emergent complexity” of the development of literature or at least writing.
On October,19,2017 I watched a Ted Talk Called “ Dangers of a single story” by Chimamanda Ngozi Adichie. She spoke about her life in Nigeria before she studied abroad in The United States of America and the dangers of knowing 1 side of the story this is also known as ‘Bias’. After watching Chimamanda Ngozi Adichie’s Ted talk, I believe not everyone in Africa lives in poverty, stereotypes in Children 's books cause unrealistic ideas of reality and the media fabricates news to generate views and labels specific groups of people.
Cancer is one of the leading causes of death worldwide as it can develop in almost any organ or tissue. Significant advances in understanding the cellular basis of cancer and the underlying biological mechanisms of tumour has been vastly improved in the recent years (Jiang et al. 1994). Cancer is a genetic disease which requires a series of mutation during mitosis to develop, its characteristics can be associated with their ability to grow and divide abnormal cells uncontrollable while in the mean time invade and cause nearby blood vessels to serve its need. Even though many people are affected by cancer today, the abilities which cancer cells have make it hard to find a single effective treatment for cancer. The focus of research now lies
Its function is to divide systemic circulation of the whole body from the cerebrospinal fluids. The tight junctions present between adjacent cells provide the means of filtration and thus forcing molecules to filter through them. The barrier also has different transport systems that allow molecules to enter, but restricting many larger molecules from entering (i.e. therapeutic drugs). In addition, the BBB also has large amounts of efflux pumps, which readily removes even more therapeutic drugs away. When the tumor grows larger, the structure (arrangements and contact of the astrocytes and pericytes) will be altered and filtration permeability will be increased. Although its properties have been affected, it has been shown that BBB remains intact. Hence, one must find strategies to deliver therapeutic drugs through the BBB. Recent research has shown by using antibodies against transferrin, insulin and lipoprotein receptor-related protein (LRP-1; involved with the transport of proteins and peptides), there is an increase in effective penetration through the
Despite the promise of such approaches, a number of difficulties remain to be overcome, the most important of which is the need for more efficient systems of gene delivery. No gene transfer system is 100% efficient, unless germ-line therapy is contemplated. During the past two decades, there have been major advances in our understanding of how cancer develops, proving that cancer has a genetic basis (2). A series of genetic abnormalities that accumulate in one cell may result in a pattern of abnormal clonal proliferation. Our growing understanding of the genetic basis of cancer offers new opportunities for the molecular prevention and treatment of cancer. There has been a
The guest speaker was Tripp Transou who has a bachelor’s degree in the field of economics from Duke University. After wanting to be in the Ann Hauser Busch Company he went back to school to receive a business degree in Marketing and Finance. He later left the company to start his own business called, Tri-Eagle and later purchased a distribution company called, Bernie Little.