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Friedreich's Ataxia Analysis

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Frataxin is a nucleus encoded mitochondrial protein that is highly conserved in bacteria and in eukaryotic organisms. Reduced frataxin levels in mitochondria have been linked to the neurodegenerative disease Friedreich's ataxia, the most common type of ataxias. At the molecular level frataxin deficiency has been shown to cause higher levels of reactive oxygen species (ROS), among which is the hydroxide radical HO•, a product of the Fenton reaction in which Fe2+ reacts with hydrogen peroxide
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